Incidence of Basal Cell Carcinoma Multiplicity and Detailed Anatomic Distribution: Longitudinal Study of an Australian Population

Abstract

A proportion of individuals are affected multiple times by basal cell carcinoma (BCC), but the rate and extent to which this occurs is unknown. We therefore prospectively estimated BCC incidence in a subtropical Australian population, focusing on the rate at which persons develop multiple primary BCCs and the precise anatomic sites of BCC occurrence. Between 1997 and 2006, 663 BCCs were confirmed in 301 of 1,337 participants in the population-based Nambour Skin Cancer Study. The incidence of persons affected multiple times by primary BCC was 705 per 100,000 person years compared to an incidence rate of people singly affected of 935 per 100,000 person years. Among the multiply and singly affected alike, site-specific BCC incidence rates were far highest on facial subsites, followed by upper limbs, trunk, and then lower limbs. We conclude that actual BCC tumor burden is much greater in the population than is apparent from normal incidence rates. Anatomic distribution of BCC is consistent with general levels of sun exposure across body sites.

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

“…1,9,15,16 A considerable percentage of the patients had multiple lesions, principally the men, giving strength to the concept of the occurrence of new lesions in individuals with a previous diagnosis of BCC. 20,21 This study found no evidence of any increase in the proportion of younger patients or in the proportion of female patients in recent years, contradicting observations made in some international studies. [5][6][7][8][9][10][11][12][13][14] Nevertheless, a greater proportion of extra-cephalic lesions was observed in recent years compared to previous years, principally among women.…”

Measurements of the anatomical distribution of erythemal ultraviolet: a study comparing exposure distribution to the site incidence of solar keratoses, basal cell carcinoma and squamous cell carcinoma

“…The facial distribution of BCC incidence has been detailed by Brodkin et al 14 , Scrivener et al 24 and more recently by Richmond-Sinclair et al 25 in and Australian setting. These studies show high rates of BCC incidence to the nose.…”

Molecularbiology of Basal Cell Carcinoma

“…In addition to histopathological assessment, assessing the spread of the primary tumor (T1<2cm, T2 2cm) according to the TNM classification (115) is crucial for assessing further development of the disease. The risk of recurrence of each tumor is defined as closely as possible to enable choice and application of the most appropriate clinical procedure (51,116,117). Tumor size is important for prognosis of the disease, as is shown by comparison in Kaplan-Meier curves.…”