Incidence of Biliary Stricture After Transarterial Chemoembolization for Hepatocellular Carcinoma in Orthotopic Liver Transplant Patients

Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation

“…1). [10][11][12][13][14][15][16][17][18][19][20][21][22][23] Combined, these retrospective studies represent a total of 1,122 patients who underwent neo-adjuvant TACE or trans arterial embolization for HCC prior to liver transplantation, and 2,703 patients not bridged with TACE. Seven studies described solely hepatic artery complications, three studies described both hepatic artery and biliary tract complications, and four studies described biliary tract complications only.…”

“…11,[13][14][15][16][17][18]20,21,23 Meta-analysis of biliary tract complications comprised data of seven studies. [10][11][12]15,17,19,22 One study with a limited follow up time of 7 days was excluded from the analysis. 28…”

“…4). [10][11][12][13]15,17,19,22 . There was no significant between study heterogeneity in the analyses.…”

“…The incidence of arterial and/or biliary complications after liver transplantation in patients treated with TACE has been explored in observational studies, however the majority of these studies lack power to detect a clinically significant difference. [10][11][12][13][14][15][16][17][18][19][20][21][22][23] We aimed to investigate the impact of TACE prior to liver transplantation on occurrence of hepatic artery and biliary tract complications after liver transplantation by pooled analyses of published cohorts.…”

Number of Local Regional Therapies for Hepatocellular Carcinoma and Peri-Operative Outcomes after Liver Transplantation

“…As shown in Table 1, patients who received 0 LRTs were less likely to have multifocal disease and had HCC tumors that were significantly smaller than those of patients who received at least 1 LRT. The patients who received 0 LRTs prior to transplant had significantly higher median MELD scores prior to transplant than patients who had at least 1 LRT: 21 (IQR 17, 28) vs. 11 (IQR 8,14) for patients who received 1-2 LRTs. The breakdown of the number and type of LRTs received by this cohort is shown in Figure 1.…”