Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study

Pan, Yueh; Lee, Chia-Yi; Lee, Liang Ming; Wen, Yu; Huang, Jing‐Yang; Yang, Shun Fa; Hsiao, Chi Hao

doi:10.3390/medicina56090441

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…Padureanu et al described a case of a 20-year-old patient, with complaints of hematuria, dysuria, and colicky pain, which were later found to be the caused by the urological manifestation of tuberous sclerosis complex (TSC) [35]. Pan et al assessed the incidence of bladder cancer in patients with Type 2 diabetes mellitus (T2DM) in a study population of 31,932 T2DM patients, compared to the control group of 63,864 patients without diabetes: overall, they have found that T2DM patients do not have a higher risk of developing bladder cancer [36]. Lee et al studied the potential anticancer properties of epigallocatechin gallate (EGCG) on a human urinary bladder transitional cell carcinoma (TCC) cell line; during the analyses, the expression profiles of mRNAs and microRNAs were analyzed using next-generation sequencing (NGS) and bioinformatics.…”

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confidence: 99%

The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature

Gajdács

2020

Medicina

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Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) in the affected patients. Among these diseases, infections and malignancies in this anatomical region are some of the most important illnesses in human medicine; nevertheless, benign prostate hyperplasia (BPH), erectile dysfunction, hypospadias, urinary incontinence, and vesicoureteral reflux are also relevant disorders affecting millions. The publication of various microbiological and clinical studies in urology from different geographical regions has important ramifications from the standpoint of epidemiology: on one hand, reported data may influence the development of therapeutic guidelines for urinary tract infections (UTIs) (empiric antibiotic-therapy) and malignancies (including classical cytotoxic drug protocols and next-generation anticancer therapies) both locally and internationally; on the other hand, the relevant stakeholders and government representatives often base their decisions on published evidence. Therefore, novel studies in the field of urology are strongly encouraged to maintain and improve the high standard of patient care internationally and to ensure continuous information supply for international datasets on the causative agents of UTIs and cancer registries. The present Editorial aims to highlight some relevant studies published from the field of urology in Medicina over the last several years.

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confidence: 99%

The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature

Gajdács

2020

Medicina

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“…DM was also a risk factor for bladder cancer. It was associated with cancer incidence and poor prognosis [23][24][25]. In the present study, bladder cancer patients with DM who were ever-smokers had a multiplier effect, which significantly increased the overall and specific mortality rates.…”

Section: U N C O R R E C T E D a U T H O R P R O O Fmentioning

confidence: 60%

“…Regarding women, the correlation between smoking and mortality will need to be investigated further in the future. Last, all patients were treated in the Taiwanese medical system, indicating a potential lack of generalizability, although some studies have confirmed the accuracy of the information in Taiwan’s National Health Insurance Research Database [ 35 ], and some topics which were discussed in our study have been published internationally, such as bladder cancer [ 36 ] and smoking [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Smoking and Overall and Specific Mortality in Patients with Bladder Cancer: A Population-based Study

Tseng

Huang

et al. 2022

Bladder Cancer

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BACKGROUND: The role of smoking in the prognosis of bladder cancer may significantly impact clinical management. It is also a considerable burden to Taiwan’s economy and health of its citizens. OBJECTIVE: To search Taiwan’s National Health Insurance Research Database to determine whether smoking affected overall and cancer-specific mortality of patients with bladder cancer. METHODS: We collected data on basic information, tumor stage, and comorbidities. Each smoking case was propensity score-matched by age, sex, and diagnosis year to one control individual among bladder cancer patients. The study comprised a never-smoke and an ever-smoke group, with each group including 4,728 patients after matching. We evaluated the association between smoking and mortalities in patients with bladder cancer. Cox proportional regression modeling was used to estimate hazard ratios (HRs) of overall and cancer-specific mortality rates. Stratified analysis was also performed to estimate risk ratios of overall and cancer-specific mortalities in bladder cancer patients with and without a history of smoking history among different subgroups. RESULTS: The overall and specific mortality ratio of patients who were ever smokers were 1.15-fold and 1.16-fold, respectively, compared with those of never smokers (overall: 95% confidence interval [CI], 1.06–1.26, P = 0.0014; specific: 95% CI, 1.03–1. 03, P = 0.0176). Patients with bladder cancer who smoked and had significantly higher overall and specific mortality rates were those with Charlson Comorbidity Index (CCI)≥3 (overall: P = 0.0119; specific: P = 0.0092), diabetes mellitus (DM; overall: P = 0.0046; specific: P = 0.0419), and non-muscle-invasive bladder cancer (NMIBC; overall: P = 0.0038; specific: P = 0.0014). CONCLUSIONS: Overall and specific mortality rates were significantly higher in the ever-smoke group than in the never-smoke group. The ever-smoke group with male sex, CCI≥3, DM, and NMIBC had increased risks for overall and specific mortality.

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“…The UK biobank observed stronger associations in women, and also found positive associations with T2DM medication and longer duration, and with glycated hemoglobin levels [ 25 ]. Regarding cohort studies of diabetics, a Taiwanese cohort study [ 27 ] of diabetic patients found no association (without adjusting for important bladder cancer risk factors such as smoking), whereas a Korean study reported positive associations with T2DM after multivariable adjustment for confounders, and also with T2DM duration and impaired fasting glucose [ 28 ]. An Italian study [ 7 ] also found a positive association with bladder cancer in T2DM patients, but they only adjusted for age and sex.…”

Section: Discussionmentioning

confidence: 99%

Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study

van den Brandt

2024

Eur J Epidemiol

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Meta-analyses have shown modest positive associations between diabetes mellitus (DM) and bladder cancer risk, but results are heterogeneous. This might be due to lack of distinction between bladder cancer subtypes, between sexes, and possibly between Type 2 and Type 1 DM (T2DM and T1DM). The relationship of T2DM (and secondarily T1DM) characteristics with risk of bladder cancer subtypes (invasive versus noninvasive) was investigated in the Netherlands Cohort Study. In 1986, 120,852 men and women aged 55–69 years provided information on DM and lifestyle data. After 20.3 years of follow-up, multivariable case-cohort analyses were based on 1020 invasive and 1088 noninvasive bladder cancer cases, and 4267 subcohort members with complete data on DM and confounders. While T2DM was not associated with noninvasive bladder cancer, it was statistically significantly associated with invasive bladder cancer risk: the multivariable-adjusted was HR = 1.57 (95% CI 1.04–2.37), comparing participants with T2DM versus without DM. The association was only significant in women, and women showed a stronger association [HR = 2.19 (95% CI 1.10–4.34)] between T2DM and invasive bladder cancer than men [HR = 1.42 (95% CI 0.88–2.30)]; interaction by sex was nonsignificant. Associations were stronger positive in those whose age at diagnosis of T2DM was 55+ years, and in those diagnosed with T2DM less than five years before baseline. T2DM participants using antidiabetic medication had higher invasive bladder cancer risk than those without DM. Exploratory age-sex-adjusted analyses suggested a positive association between T1DM and invasive bladder cancer, but this was based on few cases. These findings suggest that T2DM and possibly T1DM are positively associated with invasive bladder cancer risk.

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Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study

Cited by 6 publications

References 41 publications

The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature

The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature

Association between Smoking and Overall and Specific Mortality in Patients with Bladder Cancer: A Population-based Study

Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study

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