Incidence of breast carcinoma in women with thyroid carcinoma

Vassilopoulou‐Sellin, Rena; Palmer, Lynn; Taylor, Brynn; Cooksley, S.

doi:10.1002/(sici)1097-0142(19990201)85:3<696::aid-cncr20>3.0.co;2-4

Cited by 76 publications

(46 citation statements)

References 29 publications

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“…However, the increase is unlikely to be due to radiotherapy for breast cancer, since the risk of breast cancer is also significantly increased after thyroid cancer diagnosed under age 40 (SIR 1.97). This supports findings reported previously (Ron et al, 1984;Vassilopoulou-Sellin et al, 1999). Genetic syndromes associated with a predisposition to thyroid cancer include Cowden disease (Liaw et al, 1997); ataxia telangiectasia (Swift et al, 1987); inherited multiple endocrine neoplasia type II (Schimke, 1984); familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC) (Houlston and Stratton, 1995).…”

Section: Discussionsupporting

confidence: 86%

Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

et al. 2001

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Summary Among women in the Thames Cancer Registry database with a first breast cancer diagnosed between 1961-1995 observed numbers of subsequent cancers were compared with expected numbers and standardized incidence ratios were calculated. The occurrence of breast cancers subsequent to cancers at other sites was also examined. Women diagnosed with breast cancer before age 50 had significantly elevated risks for 9 cancer sites namely, oesophagus, stomach, lung, bone, connective tissue, breast, corpus uteri, ovary and myeloid leukaemia compared with 2 sites (corpus uteri and myeloid leukaemia) in women diagnosed at age 50 and above. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes, shared environmental factors, or therapy.

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Section: Discussionsupporting

confidence: 86%

Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

et al. 2001

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“…Vassilopoulou-Sellin et al (24) published one of the first studies on this, including 41 686 patients with breast carcinoma and 3662 with thyroid carcinoma, which were retrospectively analyzed. Among 18 931 women with a diagnosis of breast carcinoma, 11 developed DTC more than 2 years after the initial diagnosis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer

Verkooijen¹,

Smit²,

Romijn³

et al. 2006

eur j endocrinol

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Objective: The aim of the present study is to assess the prevalence of second primary tumors in patients treated for thyroid cancer. Furthermore, we wanted to assess the standardized risk rates for all second primary tumors, but especially for breast cancer, as data in the literature indicate an excessive risk in differentiated thyroid cancer (DTC) patients for this tumor. Materials and methods: We included consecutive patients, who received ablation treatment with I-131 at the Leiden University Medical Center between January 1985 and December 1999 (nZ282). The mean period of follow-up was 10.6G4.1 years. Results: Thirty-five of the 282 patients (12.4%) had a second primary tumor (SPT), either preceding or following the diagnosis of thyroid cancer. Five other patients had three primary tumors, including DTC. As a result, 40 additional tumors were found in this group, revealing an overall prevalence of 14.2%. Twenty tumors (7.1%) preceded the thyroid cancer with a mean interval of 5.7 years (range: 0.5-22.0 years), whereas 20 tumors (7.1%) occurred after this tumor with a mean interval of 6.7 years (range: 1.0-15.0 years). In 13 female patients, breast cancer was found as SPT. The standardized incidence rate (SIR) for all cancers after the diagnosis of DTC in this study population was not increased (1.13; confidence interval (CI): 0.68-1.69). However, we found an increased SIR of 2.26 (CI: 1.60-3.03) for all cancers either following or preceding DTC, which is mainly caused by a SIR of 3.95 (CI: 2.06-6.45) for breast cancer. Conclusion: Patients with DTC have an overall increased standardized incidence rate for second primary tumors, but not for second primary tumors following I-131 therapy. These findings suggest a common etiologic and/or genetic mechanism instead of a causal relation.European Journal of Endocrinology 155 801-806

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“…44 Likewise, a large retrospective study of 41,686 breast cancer patients and 3,662 thyroid cancer patients seen at MD Anderson Hospital reported a significantly increased risk of developing breast cancer after thyroid cancer in young women. 45 This finding was explored further using the National Cancer Institute's Surveillance, Epidemiology and End Results database with 1,333,115 person-years of data. Women who were diagnosed with thyroid cancer had a significantly increased risk of developing breast cancer.…”

Section: Fig 3 Comparison Of Treatment Effects On the Thyroid Hormomentioning

confidence: 99%

Seaweed and Soy: Companion Foods in Asian Cuisine and Their Effects on Thyroid Function in American Women

Teas

Braverman

Kurzer

et al. 2007

Journal of Medicinal Food

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Seaweeds and soy are two commonly eaten foods in Asia. Both have been reported to affect thyroid function, seaweed because of its iodine content and soy because of its goitrogenic effect. Twenty-five healthy postmenopausal women (mean age 58 years) completed a double-blinded randomized crossover study. Ten capsules (5 g/day) of placebo or seaweed (Alaria esculenta), providing 475 g of iodine/day, were consumed daily for 7 weeks. A powdered soy protein isolate (Solae Co., St. Louis, MO), providing 2 mg of isoflavones/kg of body weight, was given daily during the last week of each treatment arm. On average, this provided 141.3 mg of isoflavones/day and 67.5 g of protein/day. Blood samples and 48-hour urine samples were collected before and after each intervention period, and urinary I/C (g of iodine/g of creatinine) and serum thyroxine, free thyroxine index, total triiodothyronine, and thyroid stimulating hormone (TSH) were measured. Seaweed ingestion increased I/C concentrations (P Ͻ .0001) and serum TSH (P Ͻ .0001) (1.69 Ϯ 0.22 vs. 2.19 Ϯ 0.22 U/mL, mean Ϯ SE). Soy supplementation did not affect thyroid end points. Seven weeks of 5 g/day seaweed supplementation was associated with a small but statistically significant increase in TSH. Soy protein isolate supplementation was not associated with changes in serum thyroid hormone concentrations.

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Incidence of breast carcinoma in women with thyroid carcinoma

Cited by 76 publications

References 29 publications

Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer

Seaweed and Soy: Companion Foods in Asian Cuisine and Their Effects on Thyroid Function in American Women

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