Incidence of Canine Glaucoma with Goniodysplasia in Japan: A Retrospective Study

Kato, Koichi; Sasaki, Nobuo; Matsunaga, Satoru; Nishimura, Ryohei; Ogawa, Hiroyuki

doi:10.1292/jvms.68.853

Cited by 21 publications

(22 citation statements)

References 17 publications

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“…Kato, et al, reported that the Beagle breed has the fourth-highest incidence of canine glaucoma, after Shiba-Inu, Shih-Tzu, and American Cocker Spaniel breeds [18]. Kuchtey et al recently reported that the Gly661Arg variant (56097365 G>A) of ADAMTS10 in Beagles with POAG is a candidate, predictive gene allele for canine POAG [12].…”

Section: Discussionmentioning

confidence: 99%

“…Recent study reported the Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant for POAG Beagles [12]. Kato et al investigated the incidence of canine POAG, and reported that Shiba-Inus exhibited the highest incidence of glaucoma among 29 breeds, followed by Shih-Tzus [18]. They also reported that an abnormal iridocorneal angle and dysplastic prectinate ligament were associated with a high incidence of glaucoma in Shiba-Inus and Shih-Tzus.…”

Section: Introductionmentioning

confidence: 99%

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Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk

et al. 2013

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Glaucoma is a degenerative optic neuropathy that is associated with elevated intraocular pressure. Primary open angle glaucoma is the most common type of glaucoma in canines, and its highest incidence among dog breeds has been reported in Shiba-Inus, followed by Shih-Tzus. These breeds are known to have an abnormal iridocorneal angle and dysplastic prectinate ligament. However, the hereditary and genetic backgrounds of these dogs have not yet been clarified. In this study, we investigated the association between polymorphisms of the glaucoma candidate genes, SRBD1, ELOVL5, and ADAMTS10, and glaucoma in Shiba-Inus and Shih-Tzus. We analyzed 11 polymorphisms in these three genes using direct DNA sequencing. Three SRBD1 SNPs, rs8655283, rs22018514 and rs22018513 were significantly associated with glaucoma in Shiba-Inus, while rs22018513, a synonymous SNP in exon 4, showed the strongest association (P = 0.00039, OR = 3.03). Conditional analysis revealed that rs22018513 could account for most of the association of these SNPs with glaucoma in Shiba-Inus. In Shih-Tzus, only rs9172407 in the SRBD1 intron 1 was significantly associated with glaucoma (P = 0.0014, OR = 5.25). There were no significant associations between the ELOVL5 or ADAMTS10 polymorphisms and glaucoma in Shiba-Inus and Shih-Tzus. The results showed that SRBD1 polymorphisms play an important role in glaucoma pathology in both Shiba-Inus and Shih-Tzus. SRBD1 polymorphisms have also been associated with normal- and high-tension glaucomas in humans. Therefore, SRBD1 may be a common susceptibility gene for glaucoma in humans and dogs. We anticipate that the nucleotide sequencing data from this study can be used in genetic testing to determine for the first time, the genetic status and susceptibility of glaucoma in dogs, with high precision. Moreover, canine glaucoma resulting from SRBD1 polymorphisms could be a useful animal model to study human glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk

et al. 2013

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“…Goniodysgenesis: Background and Nomenclature GD, 3,4 also known as pectinate ligament dysplasia (PLD), 3,[5][6][7][8][9][10][11][12] or goniodysplasia 13,14 is a congenital ICA abnormality that, when extensive, may predispose to the development of glaucoma later in life. 3,10,15 A normal canine ICA (Figs.…”

Section: Glaucoma-induced Changes In the Canine Anterior Segmentmentioning

confidence: 99%

Microscopic Lesions in Canine Eyes with Primary Glaucoma

Beamer

Reilly

Pizzirani

2015

Veterinary Clinics of North America: Small Animal Practice

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“…However, openangle glaucoma (OAG) is also a hereditary problem with the presence of glaucoma in one's family increasing the risk of developing glaucoma four-to nine-fold over that of individuals with no hereditary glaucoma background. 6 Among young adults, especially African-Americans, glaucoma is the leading cause of blindness, 7 which is 6-8 times more common than in Caucasians. 2 The American Hispanic population has the greatest risk of developing glaucoma more rapidly and at a younger age, 8 while people of Asian descent appear to have no significant risks of developing glaucoma.…”

Section: Loss Of Vision: Causes and Incidencesmentioning

confidence: 99%

Can mammalian vision be restored following optic nerve degeneration?

Kuffler¹

2016

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For most adult vertebrates, glaucoma, trauma, and tumors close to retinal ganglion cells (RGCs) result in their neuron death and no possibility of vision reestablishment. For more distant traumas, RGCs survive, but their axons do not regenerate into the distal nerve stump due to regeneration-inhibiting factors and absence of regeneration-promoting factors. The annual clinical incidence of blindness in the United States is 1:28 (4%) for persons >40 years, with the total number of blind people approaching 1.6 million. Thus, failure of optic nerves to regenerate is a significant problem. However, following transection of the optic nerve of adult amphibians and fish, the RGCs survive and their axons regenerate through the distal optic nerve stump and reestablish appropriate functional retinotopic connections and fully functional vision. This is because they lack factors that inhibit axon regeneration and possess factors that promote regeneration. The axon regeneration in lower vertebrates has led to extensive studies by using them as models in studies that attempt to understand the mechanisms by which axon regeneration is promoted, so that these mechanisms might be applied to higher vertebrates for restoring vision. Although many techniques have been tested, their successes have varied greatly from the recovery of light and dark perceptions to partial restoration of the optomotor response, depth perception, and circadian photoentrainment, thus demonstrating the feasibility of reconstructing central circuitry for vision after optic nerve damage in mature mammals. Thus, further research is required to induce the restoration of vision in higher vertebrates. This paper examines the causes of vision loss and techniques that promote transected optic nerve axons to regenerate and reestablish functional vision, with a focus on approaches that may have clinical applicability.

show abstract

Incidence of Canine Glaucoma with Goniodysplasia in Japan: A Retrospective Study

Cited by 21 publications

References 17 publications

Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk

Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk

Microscopic Lesions in Canine Eyes with Primary Glaucoma

Can mammalian vision be restored following optic nerve degeneration?

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