Incidence of catheter-related bloodstream infections after removal of peripherally inserted central catheters in preterm neonates

Tomar, Rampal Singh; Gupta, Ashish; Khan, Inam Danish

doi:10.18203/2349-3291.ijcp20200018

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…[ 10 ] For premature infants, during the implementation of PICC treatment, CRBSI will not only cause varying degrees of damage to their body, but also prolong the treatment time and increase the family economic pressure of premature infants. [ 11 , 12 ] Therefore, mastering the risk factors of CRBSI in premature infants with PICC plays an important role in reducing the incidence of CRBSI.…”

Section: Introductionmentioning

confidence: 99%

Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates

Zhang,

Li,

et al. 2024

Medicine

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To investigate the incidence, risk factors, and pathogenic characteristics of catheter-related bloodstream infection caused by peripherally inserted central venous catheter in neonates, and to provide references for reducing the infection rate of peripherally inserted central venous catheter. The clinical data of 680 neonates who underwent peripherally inserted central catheter (PICC) in the neonatal intensive care unit from June 2020 to June 2023 were retrospectively analyzed. The risk factors and independent risk factors of catheter-related bloodstream infection caused by PICC were determined by univariate and multivariate analysis, respectively. Catheter-related bloodstream infection occurred in 38 of 680 neonates who underwent PICC. The infection rate was 4.74%. The proportions of fungi, gram-positive bacteria, and gram-negative bacteria were 42.11%, 36.84%, and 21.05%, respectively. Candida parapsilosis was the main fungus (18.42%), coagulase negative Staphylococcus was the main gram-positive bacteria (23.68%), and Klebsiella pneumoniae and Escherichia coli were the main gram-negative bacteria (7.89%). Univariate analysis showed that gestational age ≤32 weeks, birth weight ≤1500 g, congenital diseases, nutritional support, catheterization time, 5-minute APGAR score ≤7, and neonatal respiratory distress syndrome were associated with catheter-related bloodstream infection caused by PICC. Multivariate analysis showed that premature delivery, low birth weight, parenteral nutrition, long catheterization time, and 5-minute APGAR score ≤7 were associated with catheter-related bloodstream infection caused by PICC. Among the pathogens detected, there were 6 cases of K pneumoniae, 5 cases of coagulase negative staphylococci, and 2 cases of fungi. Low birth weight, premature delivery, off-site nutrition, long catheterization time, and 5-minute APGAR score ≤7 are independent risk factors for catheter-related bloodstream infection in neonates with peripherally inserted central venous catheters. The pathogenic bacteria are fungi and multidrug-resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates

Zhang,

Li,

et al. 2024

Medicine

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Antiseptic solutions for skin preparation during central catheter insertion in neonates

Helmi

Lai

Rostenberghe

et al. 2023

Cochrane Database of Systematic Reviews

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Efficacy of antimicrobial-impregnated catheters in preventing sepsis post epicutaneo-caval catheter (ECC) removal in neonates: A retrospective study

Al Khateeb,

Gad,

Mahmah

et al. 2024

J Vasc Access

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Background: Epicutaneo-caval catheters (ECC) are vital in neonatal intensive care units (NICU) in enabling prolonged venous access. Despite their benefits, central line-associated bloodstream infections (CLABSI) pose a potential risk. The ECC removal procedure may contribute to an increased risk of post removal sepsis through biofilm release. Antimicrobial-impregnated ECCs have been proposed as a potential solution to prevent this complication, but research on their effectiveness in neonates is limited. Objective: To compare post-ECC or neonatal peripherally inserted central catheter (n-PICCs) removal sepsis rates when using conventional or antimicrobial-impregnated catheters in neonates. Methods: A retrospective, single center cohort analysis using 2019 data from 421 neonates after successful ECC insertion at the Women’s Wellness and Research Center, a large tertiary level NICU in Qatar. The study systematically collected data on demographics, insertion, and removal as well as microbiology, and infection data. Statistical analyses compared conventional and antimicrobial ECCs, with a focus on the incidence of sepsis within 72 hr post-removal. Results: After excluding non-eligible, 349 cases were included in the analysis (138 conventional, 211 antimicrobial-impregnated). There were no significant demographic differences between the two groups. The CLABSI incidence was higher amongst the antimicrobial ECC group (4% vs 0.6%, p = 0.031). Among the included neonates, the confirmed post-removal sepsis incidence was 4.3% (6 cases) for the conventional and 10% (21 cases) for the antimicrobial ECC groups, which was not statistically significant ( p = 0.055). Conclusion: The study noted a higher, but statistically insignificant, incidence of post removal sepsis when using antimicrobial-impregnated ECCs. This finding raises questions about the effectiveness of antimicrobial ECCs in preventing post-removal sepsis in this patient population. Further randomized trials are needed to assess the role of antimicrobial ECCs amongst neonates and to refine neonatal ECC care strategies.

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Incidence of catheter-related bloodstream infections after removal of peripherally inserted central catheters in preterm neonates

Cited by 4 publications

References 9 publications

Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates

Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates

Antiseptic solutions for skin preparation during central catheter insertion in neonates

Efficacy of antimicrobial-impregnated catheters in preventing sepsis post epicutaneo-caval catheter (ECC) removal in neonates: A retrospective study

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