Incidence of ceftriaxone‐associated gallbladder pseudolithiasis

Papadopoulou, Frederica; Efremidis, Stavros C.; Karyda, Stavroula; Badouraki, Maria; Karatza, Eliza; Panteliadis, Christos P.; Malaka, K

doi:10.1111/j.1651-2227.1999.tb01050.x

Cited by 52 publications

(24 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In other 4 patients disappearance of gallstones was observed, but three of them had a pseudolithiasis (following antibiotic-therapy with ceftriaxone) and one had fetal gallstones. Since these conditions are described as auto-resolving diseases [20][21][22][23] , the disappearance was not There were no post-operative complication and in no case residual cholelithiasis or recurrence of gallstones during the follow-up were observed. In three patients recurrence of clinical symptoms after treatment (post-cholecystectomy syndrome) was described.…”

Section: Patients Observed At Medical Departmentsmentioning

confidence: 99%

Management of cholelithiasis in Italian children: A national multicenter study

Corte¹,

Falchetti²,

Nebbia³

et al. 2008

WJG

View full text Add to dashboard Cite

development of complications was reported. CONCLUSION:The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. INTRODUCTIONIn the last years following the extensive use of ultrasound scanning an increasing number of children with cholelithiasis has been identified. In a population based study, prevalence of gallstones and biliary sludge in children was of 1.9% and 1.46%, respectively [1] . In an analogue study, performed in Italian adults, the overall prevalence of gallstones diseases was of 9.5% in men and 18.9% in women [2] . Gallstones disease is the most common and costly of all digestive disease in the United States, resulting in 700 000 cholecystectomies and as many as 1 000 000 hospitalizations annually [3] . The frequency of hospital admission and operation for gallstones increased in Western countries since the 1950s [4] . In England the age-standardized hospital admission rate for cholelithiasis enhanced from 68.7 to 104.9 per 100 000 population between 1989/1990 and 1999/2000 and it increased progressively with age from 1.1 per 100 000 in the 0-14 year age group to 277.1 per 100 000 in the ≥ 85-year age group in 1999/2000 [5] . Guidelines for management of cholelithiasis are available for adults. Cholecystectomy is recommended for

show abstract

Section: Patients Observed At Medical Departmentsmentioning

confidence: 99%

Management of cholelithiasis in Italian children: A national multicenter study

Corte¹,

Falchetti²,

Nebbia³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…The incidence of ceftriaxone-associated biliary sludge was reported between 17-57.5% (Schaad et al 1988;Papadopoulou et al 1999;Palanduz et al 2000;Herek et al 2001;Bor et al 2004;Ozturk et al 2005). Higher rates were reported with higher doses of ceftriaxone in those studies (100 mg/kg/day vs 60-70 mg/kg/day).…”

Section: Discussionmentioning

confidence: 86%

“…The formation of biliary sludge is also reported within the first 3 days of the treatment in more than half of the patients receiving ceftriaxone (Papadopoulou et al 1999). High daily dosages and long-term duration of ceftriaxone therapy seems to be the main risk factors for the development of biliary sludge.…”

Section: Discussionmentioning

confidence: 93%

“…Biliary sludge has been usually accepted as a benign condition and clinical signs are usually absent. Symptoms like right upper quadrant pain, nausea, vomiting and cholecystitis occur only in a minority of the patients (Schaad et al 1988;Schiffman et al 1990;Papadopoulou et al 1999). All subjects were asymptomatic in the study group and showed no biochemical features of cholestasis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pseudolithiasis due to Ceftriaxone Treatment for Meningitis in Children: Report of 8 Cases

Araz¹,

Okan

Demırcı

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…Bu yüzden "psödolitiyaz" olarak da adland›r›l-maktad›r (14)(15). Yap›lan çal›flmalarda seftriyakson tedavisi verilen çocuklarda yaklafl›k %25-30 oran›nda safra tafl› geliflti¤i ve tedavi kesildikten sonra k›sa sürede tafllar›n kendili¤inden kayboldu¤u bildirilmifltir (15)(16)(17). Çal›flmam›z-da hastalar›m›z›n 15'inde (%25) seftriyakson kullan›m› mevcuttu ve izlemde tafllar›n kayboldu¤u görülmüfltü.…”

unclassified

Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi

Fakirullahoğlu¹,

Dinler²,

Kalaycı³

2011

tpa

View full text Add to dashboard Cite

Ç Ço oc cu uk kl lu uk k ç ça a¤ ¤› ›n nd da a s sa af fr ra a t ta afl fll la ar r› ›: : 6 60 0 o ol lg gu un nu un n g ge er ri iy ye e d dö ön nü ük k i in nc ce el le en nm me es si i G Ga al ll ls st to on ne es s i in n c ch hi il ld dh ho oo od d: : R Re et tr ro os sp pe ec ct ti iv ve e a an na al ly ys si is s o of f 6 60 0 c ca as se es s F Fa at ti ih h F Fa ak ki ir ru ul ll la ah ho o¤ ¤l lu u, , G Gö ön nü ül l D Di in nl le er r* *, , A Ay yh ha an n G Ga az zi i K Ka al la ay yc c› ›* * S Su um mm ma ar ry yAim: The purpose of this study was to documentation of the characteristics of children with cholelithiasis by means of age, sex, clinical manifestations and risk factors. Material and Method: Sixty cases (aged 0-18 years) with ultrasonographic evidence of cholelithiasis were enrolled in the study. Results: Mean age of the patients was 7.8±5.1 years (range: 0.25-18 years), 38 (63.3%) of them were females. Underlying risk factors were identified in 34 (56.7%) of cases (15 ceftriaxone use, six hemolytic diseases, five Down's syndrome, four obesity, two total parenteral nutrition and sepsis, one inflammatory disease and one chronic cholestatic liver disease). No etiology could be found in 26 (43.3%) patients who were defined as idiopathic. Of 46 patients who were followed at least for three months, eight (17.4%) had cholecystectomy, 16 (34.8%) showed differences in stone size and the stones were resolved in 24 patients (52.2%). When the cases related to ceftriaxone use were excluded, the percentage of the disappaerance of the stones was found to be 28.3%. Ursodeoxycolic acid was effective on resolution of symptoms in 69.2% of patients. The complications of gallstones were recorded in five (8.3%) patients. Conclusions: Cholelithiasis is more common in children than previously thought. The most common risk factors are ceftriaxone use and hemolytic diseases but about half of the cases are still idiopathic. There is a need for close monitoring of patients in especially risk groups because of gallstone development and its complications. (Turk Arch Ped 2010; 45: 119-23)

show abstract

Incidence of ceftriaxone‐associated gallbladder pseudolithiasis

Cited by 52 publications

References 11 publications

Management of cholelithiasis in Italian children: A national multicenter study

Management of cholelithiasis in Italian children: A national multicenter study

Pseudolithiasis due to Ceftriaxone Treatment for Meningitis in Children: Report of 8 Cases

Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi

Contact Info

Product

Resources

About