Incidence of cerebral microbleeds

Goos, Jeroen; Henneman, Wouter J.P.; Sluimer, Jasper D.; Vrenken, Hugo; Sluimer, Ingrid C.; Barkhof, Frederik; Blankenstein, Marinus A.; Scheltens, Philip; Flier, Wiesje M. van der

doi:10.1212/wnl.0b013e3181e396ea

Cited by 117 publications

(81 citation statements)

References 37 publications

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“…9,10 However, only 1 study made separate categories according to CMB location and they did not find a relation of vascular risk factors and incidence of deep or infratentorial CMBs. 9 In our study, the association between vascular risk factors and incident deep or infratentorial microbleeds remained significant after adjustment for other markers of small vessel disease. This suggests that deep or infratentorial microbleeds are an independent indicator of hypertensive vasculopathy.…”

Section: Poels Et Al Incidence Of Cerebral Microbleeds 659mentioning

confidence: 98%

“…In contrast to the baseline cross-sectional study, 5 we now also found an association between white matter lesion volume at baseline and incidence of strictly lobar microbleeds, which is in line with other studies. 9,11 It may be hypothesized that vascular amyloid deposition alters white matter perfusion and thus causes white matter lesions through vessel stenosis, vasoactive effects of ␤-amyloid, and smooth muscle cell necrosis that results in loss of vasoreactivity. 19,20 In our study, in 12 persons (1.4% of overall study population; 5.9% of persons with CMBs at baseline), some CMBs that were present at baseline seemed to disappear over time.…”

Section: Poels Et Al Incidence Of Cerebral Microbleeds 659mentioning

confidence: 99%

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Incidence of Cerebral Microbleeds in the General Population

Poels

Ikram

Lugt

et al. 2011

Stroke

245

178

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Background and Purpose-Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time. Methods-As part of the Rotterdam Scan Study, 831 persons (mean age, 68.5 years) underwent repeated brain MRI with a mean interval of 3.4 years. We assessed determinants of incident microbleeds in relation to their location with multiple logistic regressions. Results-Overall prevalence of microbleeds increased from 24.4% at baseline to 28.0% at follow-up. Eighty-five persons (10.2%) developed new microbleeds. Microbleeds at baseline predicted development of new microbleeds (OR, 5.38; 95% CI, 3.34 to 8.67). In only 6 persons with microbleeds at baseline, fewer microbleeds were present at the follow-up examination. Cardiovascular risk factors, presence of lacunar infarcts, and larger white matter lesion volume at baseline were all associated with incident deep or infratentorial microbleeds, whereas people with the apolipoprotein E ⑀4/⑀4 genotype or larger white matter lesion volume had a higher risk of incident strictly lobar microbleeds. Conclusions-Incidence of microbleeds in the general population over a 3-year interval was substantial and microbleeds rarely disappeared. Risk factors for incident microbleeds were similar to those for prevalent microbleeds and differed according to microbleed location. These results support the assessment of microbleeds on T2*-weighted MRI as a possible marker of both cerebral amyloid angiopathy and hypertensive vasculopathy progression. (Stroke. 2011;42:656-661.)

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Section: Poels Et Al Incidence Of Cerebral Microbleeds 659mentioning

confidence: 98%

Section: Poels Et Al Incidence Of Cerebral Microbleeds 659mentioning

confidence: 99%

Incidence of Cerebral Microbleeds in the General Population

Poels

Ikram

Lugt

et al. 2011

Stroke

245

178

View full text Add to dashboard Cite

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“…28,29 By its restriction to fully published studies, our systematic review is potentially subject to publication bias. 30 Furthermore, although we sought some additional unpublished data, only 4 studies in around two-thirds of the total number of participants from relevant studies contributed data on the association Figure 3 Meta-analysis of the association between ⑀2؉ vs ⑀3/3 genotypes and brain microbleeds (BMBs) (A) BMBs in any location.…”

Section: Resultsmentioning

confidence: 99%

10 Genetic associations with brain microbleeds: systematic review and meta-analyses

Sudlow

Maxwell

Jackson

et al. 2011

Journal of Neurology, Neurosurgery & Psychiatry

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Objective: We performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs). Methods:We sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of Ͼ100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I 2 and 2 statistics to assess heterogeneity, and fail-safe N estimates to assess the robustness of our results. Results:Only the APOE ⑀2/3/4 polymorphism had been studied in Ͼ100 people (10 studies, Conclusions:Given the known associations of APOE alleles with lobar intracerebral hemorrhage and cerebral amyloid angiopathy, these findings support the concept that strictly lobar BMBs may be an imaging biomarker of cerebral amyloid angiopathy. Neurology ® 2011;77:158-167 GLOSSARY BMB ϭ brain microbleed; CAA ϭ cerebral amyloid angiopathy; CI ϭ confidence interval; GRE ϭ gradient-recalled echo; HWE ϭ Hardy-Weinberg equilibrium; ICH ϭ intracerebral hemorrhage; OR ϭ odds ratio.Brain microbleeds (BMBs) are minute deposits of blood products, seen as focal areas of signal loss typically Ͻ10 mm in diameter on haem-sensitive T2*-weighted gradient-recalled echo (GRE) MRI sequences. BMBs occur in 5% to 38% of apparently healthy people, increasing in frequency with age, hypertension, and smoking.

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“…CMBs are frequently identified in patients followed in memory clinics (Cordonnier et al., 2006; Goos et al., 2010). In line with previous studies, we identified a greater age and hypertension as risk factors associated with CMBs.…”

Section: Discussionmentioning

confidence: 99%

Background and distribution of lobar microbleeds in cognitive dysfunction

et al. 2017

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ObjectivesCerebral microbleeds (CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D‐CMBs) result from hypertensive vasculopathy (HV), whereas strictly lobar CMBs (SL‐CMBs) result from cerebral amyloid angiopathy (CAA) which frequently coexists with Alzheimer's disease (AD). Mixed CMBs (M‐CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL‐CMBs and M‐CMBs in terms of clinical features and regional distribution.MaterialsWe examined 176 sequential patients in our memory clinic for clinical features and CMB location using susceptibility‐weighted images obtained on a 3T‐MRI. The number of lobar CMBs in SL‐CMBs and M‐CMBs was counted in each cerebral lobe and their regional density was adjusted according to the volume of each lobe.ResultsOf the total 176 patients, 111 patients (63.1%) had CMBs. Within the patients who had CMBs, M‐CMBs were found in 54 patients (48.6%), followed by SL‐CMBs in 35 (31.5%) and D‐CMBs in 19 (17.1%). The SL‐CMB group showed a significantly higher prevalence of family history of dementia, whereas the M‐CMB group showed an increasing trend toward hypertension and smoking. The prevalence of AD was significantly higher in the SL‐CMBs group, whereas the prevalence of AD with cerebrovascular disease was higher in the M‐CMBs group. The regional density of lobar CMBs was significantly higher in the occipital lobe in the M‐CMB group, whereas the SL‐CMB group showed higher regional density between regions an increasing tendency in the parietal and occipital lobe.ConclusionThe between‐group differences in clinical features and regional distribution indicate there to be an etiological relationship of SL‐CMBs to AD and CAA, and M‐CMBs to both HV and CAA.

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Incidence of cerebral microbleeds

Abstract: In addition to APOE genotype, presence and progression of small-vessel disease and vascular risk factors were predictors of new MBs. The latter are potentially modifiable, suggesting the possibility of preventing incident MBs, hopefully resulting in slower clinical decline.

Cited by 117 publications

References 37 publications

Incidence of Cerebral Microbleeds in the General Population

Incidence of Cerebral Microbleeds in the General Population

10 Genetic associations with brain microbleeds: systematic review and meta-analyses

Background and distribution of lobar microbleeds in cognitive dysfunction

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