Incidence of cervical, endometrial, and ovarian cancer in Korea during 1999–2015

Abstract

ObjectiveTo investigate the incidence and trends of cervical (C53), endometrial (C54.1), and ovarian cancer (C56) among Korean females between 1999 and 2015.MethodsThe incidence of the three major gynecological cancers between 1999 and 2015 was analyzed based on the data from the Korea Central Cancer Registry. The age-standardized rates (ASRs) and the annual percent changes (APCs) for each site were calculated.ResultsThe absolute incidence rates of the three major gynecological cancers increased from 6,394 in 1999 to 8,288 in 2015. ASR for gynecologic cancer decreased from 23.7 per 100,000 in 1999 to 21.1 in 2015. This was mainly due to a definitive decrease in the incidence of cervical cancer, which recorded an APC of −3.7%. The trends of APC for gynecologic cancer were variable, being −1.36% between 1999 and 2006 and −0.11% between 2006 and 2015. A definitive but variable increase was noted for endometrial cancer, and the APC for this cancer was 7.4% between 1999 and 2009 and 3.5% between 2009 and 2015. The incidence of ovarian cancer gradually increased, with an APC of 1.8% between 1999 and 2015.ConclusionOverall, ASRs and APCs for the three major gynecological cancers are decreasing, with a recent reduction in the width of the change. However, there has been a progressive increase in the incidence of endometrial and ovarian cancers.

National screening programs for cervical cancer in Asian countries

“…In Korea, cervical cancer is the 7th most common malignancy in women, and the incidence rate is still higher than that in other developed countries [30]. Since the introduction of the NCSP in 1999 in Korea, the incidence rate of cervical cancer has gradually decreased from 16.3/100,000 to 9.1/100,000 in 2015 [31].…”

Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients

“…We reviewed all patients with primary EOC who were treated at Samsung Medical Center from January 2001 to December 2014. We retrospectively obtained data from Samsung Medical Center electronic medical records and enrolled patients depending on the inclusion criteria as follows: (1) primary EOC with International Federation of Gynecology and Obstetrics (FIGO) stage I to IV disease; (2) patients who were treated with primary debulking surgery (PDS) with adjuvant chemotherapy for primary treatment. The exclusion criteria were as follows: (1) patients who had neo-adjuvant chemotherapy with interval debulking surgery; (2) histology with non-EOC.…”

“…Being undoubtedly the most critical among gynecologic cancers, EOC shows a tendency of higher incidence in developed countries. The age-standardized incidence of ovarian cancer in Korea has been rising, reaching as much as 6.3 per 100,000 in 2015 [1]. Even with standardized management of debulking surgery followed by systemic chemotherapy has improved survival rates, 5-year survival rate was reported to be 64% in 2016, with the poorest outcome among gynecologic malignancies [2].…”

HVEM/HIF-1α promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions

“…The incidence of ovarian cancer has a progressive increase from 1999 to 2015 with annual percent changes (APC) of 1.8% in Korean [22]. It is well known that a lack of sufficient oxygen is a major characteristic of tumors, and these hypoxic conditions promote the epithelial-mesenchymal transition and tumor metastasis [23][24][25].…”