Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies

Koye, Digsu N.; Shaw, Jonathan E.; Reid, Christopher M.; Atkins, Robert C.; Reutens, Anne T.; Magliano, Dianna J.

doi:10.1111/dme.13324

Cited by 112 publications

(79 citation statements)

References 87 publications

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“…22 Notably, Asian people are more likely to have renal and β-cell dysfunction and thus, may require insulin therapy earlier than white people to achieve glycaemic control. 14,23,24 Apart from high HbA1c and BMI (by Asian criteria), the present cohort had relatively good control of other cardiometabolic risk factors, with nearly half of them treated with organ-protective drugs and > 80% of them performing self-monitoring of blood glucose.…”

Section: F I G U R E 1 Multivariable Linear Regression Analyses Of Thmentioning

confidence: 81%

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Kong

Lew²,

Lau

et al. 2020

Diabetes Obesity Metabolism

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Aims To explore the pattern of insulin use and glycaemic control in Asian people with type 2 diabetes, stratified by gender, young‐onset diabetes (YOD; diagnosed before age 40 years), and diabetic kidney disease (DKD; estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73m2). Materials and methods We conducted a cross‐sectional analysis of 97 852 patients from 11 Asian countries/regions (2007–2017) included in the prospective Joint Asia Diabetes Evaluation (JADE) Register. Results Among 18 998 insulin users (47% women, mean ± SD age 59.2 ± 11.7 years, diabetes duration 13.2 ± 8.3 years, glycated haemoglobin [HbA1c] 72 ± 21.4 mmol/mol [8.74 ± 1.95%], median total daily insulin dose [TDD] 0.27–0.82 units/kg), 25% and 29.5% had YOD and DKD, respectively. Premixed (44%) and basal‐only (42%) insulin were the most common regimens. Despite being more commonly treated with these two regimens with higher insulin dosages, patients with YOD had worse HbA1c levels than their late‐onset peers (73 ± 20.5 vs. 71 ± 21.2 mmol/mol [8.82 ± 1.87% vs. 8.66 ± 1.94%]; P < 0.001). Fewer women than men attained an HbA1c level < 53 mmol/mol (7%; 15.7% vs 17.1%; P = 0.018). Adjusting for age, diabetes duration, TDD, HbA1c, eGFR, and use of oral glucose‐lowering drugs at baseline, the odds of self‐reported hypoglycaemia were higher in women (vs. men: adjusted odds ratio [aOR] 1.16, 95% confidence interval [CI] 1.05–1.28) and in patients with DKD treated with a premixed regimen (1.81 [95% CI 1.54–2.13] vs. 1.34 [95% CI 1.16–1.54] in non‐DKD; Pinteraction < 0.001). Compared to basal‐only regimens, premixed and basal‐bolus regimens had similar HbA1c reductions but were independently associated with increased odds of hypoglycaemia (1.65 [95% CI 1.45–1.88] and 1.88 [95% CI 1.58–2.23], respectively). Conclusions In this Asian population, there were varying patterns of insulin regimens with suboptimal glycaemic control, despite relatively high TDDs, which were influenced by gender, DKD, and YOD status.

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Section: F I G U R E 1 Multivariable Linear Regression Analyses Of Thmentioning

confidence: 81%

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Kong

Lew²,

Lau

et al. 2020

Diabetes Obesity Metabolism

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“…Urinary arsenic has been dose-related to vascular disorders (Balakumar & Kaur, 2009;Moon et al, 2013;Navas-Acien et al, 2005;Srivastava et al, 2007;States, Srivastava, Chen, & Barchowsky, 2009;Tseng, 1977;Yu et al, 1984) and diabetes (Feseke et al, 2015;Navas-Acien et al, 2006). In addition, the pathological bone turnover dynamics in diabetes (Kasperk et al, 2017;Koye et al, 2017) as well as the decreased arsenic excretion in CKD may induce a vicious circle featured in increased arsenic release from the bone compartment and decreased arsenic excretion, which ultimately increase the CAsE and cause or aggravate ORAI in patients with diabetes and CKD.…”

Section: Chronic Kidney Disease Versus Diabetes Mellitus In Chronicmentioning

confidence: 99%

Chronic arsenic intoxication diagnostic score (CAsIDS)

Dani

Walter

2017

J of Applied Toxicology

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Arsenic and its compounds are well-established, potent, environmentally widespread and persistent toxicants with metabolic, genotoxic, mutagenic, teratogenic, epigenetic and carcinogenic effects. Arsenic occurs naturally in the Earth's crust, but anthropogenic arsenic emissions have surmounted the emissions from important natural sources such as volcanism. Inorganic arsenicals exhibit acute and chronic toxicities in virtually all cell types and tissues, and hence arsenic intoxication affects multiple systems. Whereas acute arsenic intoxication is rare and relatively easy to diagnose, chronic arsenic intoxication (CAsI) is common but goes often misdiagnosed.Based on a review of the literature as well as our own clinical experience, we propose a chronic arsenic intoxication diagnostic score (CAsIDS). A distinctive feature of CAsIDS is the use of bone arsenic load as an essential criterion for the individual risk assessment of chronic arsenic intoxication, combined with a systemic clinical assessment. We present clinical examples where CAsIDS is applied for the diagnosis of CAsI, review the main topics of the toxicity of arsenic in different cell and organ systems and discuss the therapy and prevention of disease caused or aggravated by chronic arsenic intoxication. CAsIDS can help physicians establish the diagnosis of CAsI and associated conditions.

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“…The consequences of diabetes are discussed in three papers. In a systematic review, Koye et al [7] describe a 2-4% annual incidence of stage 3 chronic kidney disease in people with diabetes, with only modest variation between studies, while the incidence of end-stage renal disease ranged from 0.04% to 1.8% [7]. In the next paper, reassuringly, after the first 2 years of life the offspring of mothers with diabetes had similar mortality to the rest of the population.…”

mentioning

confidence: 93%

The growth of epidemiology in diabetes research

Holt

2017

Diabet. Med.

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Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies

Cited by 112 publications

References 87 publications

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Chronic arsenic intoxication diagnostic score (CAsIDS)

The growth of epidemiology in diabetes research

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