Incidence of clinically diagnosed vertebral fractures: A population-based study in rochester, minnesota, 1985-1989

Cooper, Colin; Atkinson, Elizabeth J.; O’Fallon, W. Michael; Melton, L. Joseph

doi:10.1002/jbmr.5650070214

Cited by 1,331 publications

(515 citation statements)

References 15 publications

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“…About 10-30 % of them fail to do so and present with painful nonunions, kyphotic deformity and neurologic deficit [9]. About 60-100 % of painful nonunions become painless following VP [10,11].…”

Section: Discussionmentioning

confidence: 99%

Surgical patterns in osteoporotic vertebral compression fractures

et al. 2012

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Purpose To report morphological patterns of osteoporotic vertebral compression fractures (OVCFs) presenting for surgery. To describe surgical options based on fracture pattern. To evaluate clinical and radiological outcome. Methods Forty consecutively operated OVCFs nonunion patients were retrospectively studied. We define four patterns of OVCFs that needed surgical intervention. Group 1 mini open vertebroplasty (N = 10) no neurologic deficits and kyphotic deformity, but with intravertebral instability and significant radiological spinal canal compromise. Group 2 with neurologic deficits (N = 24) (2A)-transpedicular decompression (TPD) with instrumentation (N = 14). Fracture morphology similar to (1) and localized kyphosis \30°(2B)-pedicle subtraction osteotomy (PSO) with instrumentation (N = 10). Fracture morphology similar to (1) and local kyphosis [30°. Group 3 posterolateral decompression with interbody reconstruction (N = 06) endplate(s) destroyed, with instability at discovertebral junction, with neurologic deficit. Average follow-up was 34 months. VAS, ODI and Cobb angle were recorded at 3, 6, 12 months and yearly. Results There was significant improvement in the clinical (VAS and ODI) scores and radiologic outcome in each group at last follow-up. 30 patients out of 40, had neurologic deficits (Frankel's grade C = 16, Frankel's grade D = 14). The motor power gradually improved to Frankel's grade E. Average duration of surgery was 97 min. Average blood loss was 610 ml. Conclusion Different surgical techniques were used to suit different fracture patterns, with good clinical and radiological results. This could be a step forward in devising an algorithm to surgical treatment of OVCF nonunions.

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Section: Discussionmentioning

confidence: 99%

Surgical patterns in osteoporotic vertebral compression fractures

et al. 2012

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“…However, studies focusing on symptomatic fractures have a disadvantage in that only one-third of all vertebral fractures come to clinical attention (46). Identifying prevalent vertebral fractures is important, since prevalent vertebral deformities are associated with reduced quality of life (47), an increased mortality rate, and an increased risk of future fractures in the general population (48).…”

Section: Epidemiology and Etiology Of (Prevalent) Vertebral Fracturesmentioning

confidence: 99%

Osteoporosis and fractures in systemic lupus erythematosus

Bultink¹

2011

Arthritis Care & Research

104

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“…This is likely due to difficulty in identifying VFs, as most are clinically silent. (13) Furthermore, most studies that assessed VF risk in T2DM included only women. The Iowa Women's Health Study reported increased risk of clinical vertebral fracture in subjects with T2DM (adjusted relative risk [RR], 1.43; 95% CI, 1.05 to 1.97).…”

Section: Introductionmentioning

confidence: 99%

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Napoli

Schwartz²,

Schafer

et al. 2017

Journal of Bone and Mineral Research

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Type 2 diabetes (T2DM) is associated with a significant increase in risk of nonvertebral fractures, but information on risk of vertebral fractures (VFs) in subjects with T2DM, particularly among men, is lacking. Furthermore, it is not known whether spine bone mineral density (BMD) can predict the risk of VF in T2DM. We sought to examine the effect of diabetes status on prevalent and incident vertebral fracture, and to estimate the effect of lumbar spine BMD (areal and volumetric) as a risk factor for prevalent and incident morphometric vertebral fracture in T2DM (n ¼ 875) and nondiabetic men (n ¼ 4679). We used data from the Osteoporotic Fractures in Men (MrOS) Study, which enrolled men aged !65 years. Lumbar spine areal BMD (aBMD) was measured with dual-energy X-ray absorptiometry (DXA), and volumetric BMD (vBMD) by quantitative computed tomography (QCT). Prevalence (7.0% versus 7.7%) and incidence (4.4% versus 4.5%) of VFs were not higher in T2DM versus nondiabetic men. The risk of prevalent (OR, 1.05; 95% CI, 0.78 to 1.40) or incident vertebral-fracture (OR, 1.28; 95% CI, 0.81 to 2.00) was not higher in T2DM versus nondiabetic men in models adjusted for age, clinic site, race, BMI, and aBMD. Higher spine aBMD was associated with lower risk of prevalent VF in T2DM (OR, 0.55; 95% CI, 0.48 to 0.63) and nondiabetic men (OR, 0.66; 95% CI, 0.5 to 0.88) (p for interaction ¼ 0.24) and of incident VF in T2DM (OR, 0.50; 95% CI, 0.41 to 0.60) and nondiabetic men (OR, 0.54; 95% CI, 0.33 to 0.88) (p for interaction ¼ 0.77). Results were similar for vBMD. In conclusion, T2DM was not associated with higher prevalent or incident VF in older men, even after adjustment for BMI and BMD. Higher spine aBMD and vBMD are associated with lower prevalence and incidence of VF in T2DM as well as nondiabetic men.

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Incidence of clinically diagnosed vertebral fractures: A population-based study in rochester, minnesota, 1985-1989

Cited by 1,331 publications

References 15 publications

Surgical patterns in osteoporotic vertebral compression fractures

Surgical patterns in osteoporotic vertebral compression fractures

Osteoporosis and fractures in systemic lupus erythematosus

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

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