Incidence of Colorectal Cancer and Extracolonic Cancers in Veteran Patients With Inflammatory Bowel Disease

Mosher, Christina A.; Brown, Geri; Weideman, Rick; Crook, Terri W.; Cipher, Daisha J.; Spechler, Stuart J.; Feagins, Linda A.

doi:10.1093/ibd/izx046

Cited by 36 publications

(33 citation statements)

References 29 publications

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“…In a recent, large, retrospective study at a single medical center, men with IBD undergoing PC screening had a greater than four-fold increase in incident PC and high-grade PC compared to men without IBD 9 . In a case-control study within a shared, equal-access healthcare system, men with IBD had a 70% increased risk of PC 7 . In contrast, other studies and a meta-analysis found no clear association between IBD and PC [14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

“…While inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer 6 , associations between IBD with prostate cancer have been reported for some studies [7][8][9][10][11][12][13] but not others [14][15][16] . We thus conducted a prospective study of men from the large-scale, population-based UK Biobank cohort 17 to test this association.…”

Section: Introductionmentioning

confidence: 99%

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Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study

Meyers

Weiner

Graff

et al. 2020

Preprint

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Background: Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. Objective: To test the association between IBD with incident PC. Design, setting, and participants: We studied 218,084 men in the population-based UK Biobank cohort, aged 40-69 at study entry between 2006 and 2010, with follow-up through mid-2015. Outcome measurements and statistical analysis: We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of prostate cancer, and previous prostate-specific antigen testing. Results and limitations: Mean age at study entry was 56 years, 94% of the men were white, and 1.1% (n=2,311) had a diagnosis of IBD. After a median follow-up of 78 months, men with IBD had an increased risk of PC (adjusted hazards ratio [aHR] = 1.31, 95% Confidence interval [CI] = 1.03-1.67, p = 0.029). Separately analyzing the IBD subtypes of ulcerative colitis (UC) and Crohn's disease (CD), the association with PC was only among men with the former (UC; aHR = 1.47, 95% CI = 1.11-1.95, p=0.0070), and not the latter (CD; aHR 1.06, 95% CI = 0.63-1.80, p = 0.82). Results are limited by lack of data on frequency of health care interactions. Conclusions: In a large-scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis. Patient summary: This study of over 200,000 men in the UK suggests that men with inflammatory bowel disease may be at a higher risk of prostate cancer than the general population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study

Meyers

Weiner

Graff

et al. 2020

Preprint

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“…On the other hand, the risk of lymphoma, non-melanoma skin cancers and bladder cancer is increased by medication with thiopurine (53). A risk of developing cancer has also been shown on the skin, kidneys, prostate, and pancreas (54).…”

Section: Disease Severity and Complicationsmentioning

confidence: 99%

Self-care: the way to find balance in life : Development and evaluation of a self-care questionnaire for patients with inflammatory bowel disease

Wickman

2019

Linköping University Medical Dissertations

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Introduction: Inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD) occur worldwide and are lifelong chronic conditions. The symptoms, which include abdominal pain and frequent diarrhea, cause limitations in life. Thus, patients with IBD need self-care in accordance with their symptoms, their own commitment to maintaining health, and decisions on symptom management. To strengthen self-care, there is a need for a tool that assesses self-care in patients with IBD, which aims to support the patient dialogue about self-care. The overall aim of this thesis was to develop and evaluate a questionnaire for the clinical assessment of self-care, and to explore self-care in relation to disease activity and to health-related quality of life (HRQOL) in patients with IBD. Design and method: The thesis includes four studies, where studies I, II and IV were conducted in Sweden, and study III was conducted in the United States (U.S.). In study I, a descriptive design, interviews were conducted with twenty adult patients, in order to explore self-care in patients with IBD. In study II, the self-care questionnaire was developed and tested with 193 patients with IBD in Sweden. In study III, a cross-sectional descriptive design, the self-care questionnaire was translated into English, and the responses of 67 patients in the U.S. were evaluated. Finally, in study IV, a cross-sectional exploratory design was used to explore self-care in relation to patient characteristics, disease activity, and HRQOL among 234 patients. For a total of 421 patients, the data was analyzed using content analysis, and descriptive and analytic statistics (studies I, II, III and IV). Results: Among patients with IBD, self-care relates to symptom recognition, handling symptoms, planning life, and seeking new options. Self-care varied according to how the patient managed daily life with regard to the symptoms of the disease (study I). Based on the results from study I, the self-care questionnaire was developed in Swedish, resulting in a valid and reliable questionnaire comprising 22 items (study II). The questionnaire was translated to English, and performed self-care activities were associated with a lower degree of well-being in relation to age and gender (study III). The patients were taking medication for IBD, paying attention to their Abstract intestinal symptoms, adapting their diet, managing their stress, planning their day and avoiding activities (studies III and IV). Self-care was more frequent in patients with CD when it came to paying attention to psychological symptoms; diet adaption; avoiding various activities including sex; and looking for new approaches to living with IBD. A greater degree of selfcare activities was associated with a lower degree of HRQOL (IV). Conclusion: The results indicate the importance of identifying the total symptom experience, and of the patient's need to discuss self-care, in order to strengthen self-care and achieve better treatment. The self-care questionnaire can be a useful tool to be...

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“…The gastrointestinal tract hosts the largest population of commensal microbes in the human body, and the interplay between microbiota and the intestinal immune system has a profound influence on the pathology of colitis and CAC . Specific bacterial strains within the intestinal microbiota, such as Fusobacterium nucleatum , Escherichia coli , and Bacteroides fragilis , have been indicated as driving forces in DNA damage and tumor progression . Targeting the microbiota may have potential as a preventive and therapeutic approach to CRC …”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] Specific bacterial strains within the intestinal microbiota, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, have been indicated as driving forces in DNA damage and tumor progression. 8 Targeting the microbiota may have potential as a preventive and therapeutic approach to CRC. 9 Probiotics and their beneficial effects have been extensively studied over the past 30 years, with particular success in the management of infant diarrhea, food allergies, and IBD.…”

Section: Introductionmentioning

confidence: 99%

Single probiotic supplement suppresses colitis‐associated colorectal tumorigenesis by modulating inflammatory development and microbial homeostasis

Rong

Liu

et al. 2018

J of Gastro and Hepatol

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Background and Aim Chronic inflammation is a major contributor to the initiation and progression of cancers. Lactobacillus helveticus NS8, which was originally separated from fermented koumiss, exhibited anti‐inflammatory functions in our prior studies. In this study, NS8 was investigated for its potential to prevent colitis‐associated colorectal cancer (CAC). Methods The protective effects of NS8 against CAC was explored by employing the azoxymethane plus dextran sodium sulfate‐induced carcinogenesis mouse model. The prevalences of T cells expressing specific inflammatory cytokines were measured by flow cytometry at the early stage of CAC. Inflammatory modulation by NS8 was also tested in the Caco2‐Raw264.7 cell co‐culture system. The alternations in the intestinal microbiota following the health–inflammation–cancer sequence were analyzed by 16S rDNA sequencing. Results Oral intake of NS8 lactobacilli clearly reduced tumor number and the degree of hyperplasia. The increased proliferation of enterocytes at the early stage of CAC was significantly suppressed by NS8, while the level of apoptosis was elevated. The anticancer effects of NS8 were associated with its anti‐colitis outcomes before tumor formation. NS8 significantly suppressed the activation of NF‐κB and upregulated the anti‐inflammatory cytokine IL‐10. Further analysis revealed the marked downregulation of IL‐17‐producing T cells by NS8. Furthermore, NS8 modulated intestinal dysbiosis by promoting beneficial commensal microbes while suppressing cancer‐associated microbes. Notably, Bacteroides acidifaciens was the most sensitive commensal bacteria to NS8 intervention. Conclusion These results provide insight into the protective effects of L. helveticus NS8 against colorectal cancer.

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Incidence of Colorectal Cancer and Extracolonic Cancers in Veteran Patients With Inflammatory Bowel Disease

Cited by 36 publications

References 29 publications

Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study

Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study

Self-care: the way to find balance in life : Development and evaluation of a self-care questionnaire for patients with inflammatory bowel disease

Single probiotic supplement suppresses colitis‐associated colorectal tumorigenesis by modulating inflammatory development and microbial homeostasis

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