Incidence of congenital abnormalities in infants of gestational diabetic mothers

Amankwah, Kofi; Kaufmann, Robert C.; Roller, Randolph W.; Dawson-Saunders, Beth; Prentice, Robert L.

doi:10.1515/jpme.1981.9.5.223

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…In several other studies, researches have reported no increased risk of birth defects among infants born to mothers with gestational diabetes (5,13,21); in only a few studies have results indicated an increased risk (1,4,9). Our study shows that gestational diabetic mothers who required insulin during pregnancy were 1.9 times more likely to have an infant with a major birth defect.…”

Section: Discussionmentioning

confidence: 94%

“…Improved control of hyperglycemia during pregnancy has greatly decreased perinatal mortality but has proportionately increased the role of congenital malformations in the mortality and morbidity of infants of diabetic mothers (3,8,11). Previous studies (5-6, 16, 20-21) have reported a two to six-fold increased risk in malformations among infants 1 Corresponding author. of insulin-dependent diabetic mothers.…”

Section: Introductionmentioning

confidence: 99%

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Maternal diabetes: The risk for specific birth defects

1992

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We studied the risk for specific birth defects among infants of mothers with gestational and chronic diabetes using data collected by the Spanish Collaborative Study of Congenital Malformations (ECEMC). For the years 1976 to 1985, we identified 10,087 infants with malformations and 9,994 control infants; 155 of the case infants and 89 of the controls were born to diabetic mothers. The crude odds ratio for any minor or major defect and insulin-treated diabetes was 5.5 (95% CI = 1.2, 24.8), and for major malformations it was 8.7 (95% CI = 1.8, 34.7). The risk for defects involving the central nervous system (CNS), skeletal system and cardiovascular system were significantly increased. Infants of non-insulin-treated diabetic mothers were 2.9 times more likely to have a major congenital birth defect (95% CI = 1.2, 7.2). The crude odds ratio for any major or minor defect and mothers with gestational diabetes requiring insulin was 1.9 (95% CI = 1.1, 3.4). Similar risk was observed for major defects (OR = 1.9, 95% CI = 1.0, 3.7). These results suggest that infants of insulin-treated diabetic mothers have an increased risk of developing malformations of the CNS, cardiovascular system and skeletal system. We also found an increased risk for specific defect categories among infants of mothers with gestational diabetes treated with insulin.

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