Incidence of congenital anomalies in a rural population of Jammu - A prospective study

Ara, Anjum; Kumar, Dinesh; Dewan, Deepika; Digra, Nasib C

doi:10.4103/ijph.ijph_77_17

Cited by 8 publications

(6 citation statements)

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“…But differences still exist in various geographic areas. Gastro-intestinal system anomalies were the commonest (35%) followed by CNS (26.6%) in a study conducted in Jammu [9]. Cardiac anomalies were the commonest among newborn live births in a study reported from central India [10].However, Sarkar et al reported that musculoskeletal anomalies were commonest in their study in Eastern India [11].…”

Section: Discussionmentioning

confidence: 92%

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

Garg

Dasari

Ali

2021

Journal of Fetal Medicine

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Background Though this is an era of imaging, many women with fetal congenital malformations are presenting beyond 20 weeks of pregnancy posing problems in decision making. This study was undertaken to determine the prevalence of congenital fetal malformations presenting to tertiary health care and to analyse the gestational age at presentation and spectrum of malformations and the clinical and socio-demographic factors. Material and Methods This was a retrospective analysis of hospitalised women with diagnosis of congenital fetal malformations (CFM) from January 2017 to December 2017. The data was retrieved from Medical Records Section after due permissions and analysed with respect to socio-demographic status, age, consanguinity, type of congenital anomaly and gestational age at presentation. Results The prevalence of CFM was 1.56%. The majority (64%) of CFM were detected during the second trimester and 27% were detected in the 3rd trimester. The most common anomalies were CNS followed by multiple anomalies and 72% and 65% of them were live born respectively. The majority (90%) belonged to lower middle socioeconomic group and were from rural background (82%). The majority of women were less than 30 years of age (77.6%) and 38% were primigravidae. Consanguinity was present in 34%, medical disorders were associated in 29% and 3% had family history of congenital fetal anomalies. ConclusionThe most common anomalies were CNS and majority were primigravidae. The most common medical disorder associated was diabetes. It is possible that they are deficient in folic acid and vitamin B12. Hence pre-conceptional control of medical disorders, nutritional counselling regarding intake of micronutrients and awareness programmes to take pre-conceptional folic acid and vitamin B12 are the need of the hour for prevention.

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Section: Discussionmentioning

confidence: 92%

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

Garg

Dasari

Ali

2021

Journal of Fetal Medicine

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“…Since past few years, a number of suspected cases of genetic disorders (including new/known monogenic diseases and other known genetic diseases with atypical clinical features) have been reported from J&K region. Cases of chromosomal genetic disorders (such as Down Syndrome, Turner Syndrome, Klinefelter Syndrome, Patau Syndrome; Table 5), anemias, blood disorders (including Thalassemia), congenital anomalies, disorders of sex development, metabolic disorders like G6PD deficiency, neurological disorders (Table 6) and others are frequently reported in J&K (Razdan et al, 1994;Kumar et al, 2010;Upma et al, 2010;Vasudev and Sawhney, 2014;Ara et al, 2018;Dar et al, 2018;Hockham et al, 2018). The detrimental effects of consanguinity and inbreeding depression on child health and mortality, cognitive behavior and fertility and an increased risk of cardiovascular diseases in small population groups from J&K has also been reported (Bhasin and Nag, 2002b;Afzal, 2014a,b, 2016;.…”

Section: Burden Of Genetic Diseases In Jandkmentioning

confidence: 99%

Review: Understanding Rare Genetic Diseases in Low Resource Regions Like Jammu and Kashmir – India

et al. 2020

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“…[1][2][3] The global estimated prevalence of Congenital anomalies is between 1% and 3% and varies widely among countries. 2,5,6 Congenital anomalies affect 1 in every 33 newborns. 4 Birth prevalence of congenital anomalies is affected due to social, racial, economical, and ecological influences.…”

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confidence: 99%

“…The cause of congenital anomalies is considered multifactorial, which accounts for two-thirds of all defects. 1,5 Risk factors attributed to their development include metabolic factors, such as hypothyroidism, uncontrolled diabetes, and maternal obesity. 3,5 Maternal exposures to certain drugs (trimethoprim, phenytoin, phenobarbitone and carbamazepine), infections (TORCHs-toxoplasmosis, others (syphilis, hepatitis B), rubella, cytomegalovirus (CMV) and herpes simplex) and radiation have been implicated.…”

mentioning

confidence: 99%

“…1,5 Risk factors attributed to their development include metabolic factors, such as hypothyroidism, uncontrolled diabetes, and maternal obesity. 3,5 Maternal exposures to certain drugs (trimethoprim, phenytoin, phenobarbitone and carbamazepine), infections (TORCHs-toxoplasmosis, others (syphilis, hepatitis B), rubella, cytomegalovirus (CMV) and herpes simplex) and radiation have been implicated. 1,8 Maternal age (>35 years), family history , high birth order (>4 births) and consanguineous marriage have been reported as significant risk factors .…”

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confidence: 99%

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Neonatal outcome of babies born with congenital anomalies after pediatric surgery

Sharma,

Maletha

2024

Int J Reprod Contracept Obstet Gynecol

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Background: Congenital anomalies are the major cause of adverse neonatal outcome and mortality. Some congenital anomalies are correctable and there is immense role of pediatric surgery in treatment of these anomalies. The aim of this study was to determine the pattern of congenital anomalies and to evaluate clinical outcome of babies after surgical intervention. Methods: This hospital-based cross-sectional study was carried out in the Obstetrics and Gynecology department during the period of 1 year. All the delivered babies in this hospital during this period were examined by obstetricians and pediatricians for the presence of various congenital anomalies. Babies with correctable anomalies were operated by the Pediatric Surgery Department and outcome of babies at the time of discharge was included. Data were entered into a case record form and then in the excel sheet and were analyzed statistically. Results: During the study period, 1670 babies were delivered in our institution; of which, 32 babies had congenital malformations, giving the prevalence of 1.91%. The system involved predominantly was the gastrointestinal (GI) system (80%). Pregnancy with congenital malformation were associated with malpresentation, anemia and polyhydramnios. Overall, most babies operated for pediatric surgery had good outcome. Conclusions: Pre pregnancy high-dose folic acid supplementation, regular antenatal visits, and prenatal diagnosis are recommended for prevention, early detection and management of congenital anomalies. There is great importance of Level II and NT NB Scan. Pediatric surgery is a boon in babies with correctable anomalies.

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Incidence of congenital anomalies in a rural population of Jammu - A prospective study

Abstract: The study demonstrated that the CAs continue to occur in Jammu at a similar magnitude as reported from other parts of the country.

Cited by 8 publications

References 0 publications

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

Review: Understanding Rare Genetic Diseases in Low Resource Regions Like Jammu and Kashmir – India

Neonatal outcome of babies born with congenital anomalies after pediatric surgery

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