Incidence of contrast-induced nephropathy a prospective study

Peer, Sameer; Choh, Naseer A.; Gojwari, Tariq

doi:10.15171/jrip.2017.37

Cited by 8 publications

(15 citation statements)

References 27 publications

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“…This might be due to variable criteria and definitions of PC-AKI among the studies as well as different study designs. In Europe and the US, the incidence of PC-AKI after CTA or CTP reportedly ranges from 1.5% to 14.8% [7][8][9][10][11][12]. The risk of PC-AKI may be elevated in patients with older age, longterm and uncontrolled diabetes, renal insufficiency, and concurrent use of nephrotoxic drugs [13].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke

Chusiri

Chutinet

Suwanwela

et al. 2020

Stroke Research and Treatment

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Background. Multimodal computed tomography (CT) guides decision-making regarding use of thrombolytic agents in acute ischemic stroke patients. However, postcontrast acute kidney injury (PC-AKI) is a potential adverse effect of the contrast media used, which may require hemodialysis and cause a longer hospital stay. The incidence and risk factors of PC-AKI in acute ischemic stroke patients, particularly in Thailand, remain unclear. Goal. We aimed at determining the incidence and risk factors of PC-AKI in patients with acute ischemic stroke undergoing multimodal CT. Methods. We conducted a retrospective review of Thai acute ischemic stroke patients admitted to the King Chulalongkorn Memorial Hospital between January 2014 and December 2017 who received multimodal CT and thrombolytic treatment with alteplase. Result. Overall, 109 patients were included for analysis; eight patients (7.3%) developed PC-AKI. Estimated glomerular filtration rate eGFR≤30 mL/min and mechanical thrombectomy were risk factors significantly associated with PC-AKI. Conclusion. The incidence of PC-AKI in a real practice setting did not differ from previous reports. Two factors were associated with PC-AKI, eGFR≤30 mL/min and mechanical thrombectomy. Patients without these risk factors may not need to wait for the results of renal function testing prior to multimodal CT.

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Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke

Chusiri

Chutinet

Suwanwela

et al. 2020

Stroke Research and Treatment

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“…In the study by Shlaja et al, the average age of patients was 35.75 years. In the study conducted byPeer et al (2017) on 222 patients, the proportion of male subjects was higher than the female (men 55.8% vs women 44.2%), and the average age of patients in this study was 48.96 years. The study by Marenzi et al (2009) also found a NGAL has been studied as a potential biomarker to foretell renal injury before any functional abnormalities were observed.…”

mentioning

confidence: 53%

Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Creatinine Levels after Percutaneous Coronary Intervention

Zasra¹,

Harun

Azmi

et al. 2019

Indones J Kidney Hypertens

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Background. Contrast-induced nephropathy (CIN) is defined as an increase in serum creatinine ≥ 25% or ≥0.3 mg/dl in 48 hours after the administration of a contrast agent in the absence of other causative factors (KDIGO 2012). Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a substance produced by the kidneys in acute kidney injury (AKI) caused by various insults from ischemia to toxin-induced nephropathy. NGAL is known to increase earlier than serum creatinine level. NGAL is also a protease-resistant polypetide; it is released from the distal tubule, secreted to the urine or returned to the plasma (back leak), freely filtered in the glomerulus, reabsorbed in the proximal tubule through the megalin receptor endocytosis or secreted to urine. This makes NGAL detectable both in the blood and urine. Aim. To elucidate the effect of contrast administration to serum NGAL and serum creatinine levels with in patients undergoing PCI. Methods. The study was done in the Cardiovascular Care ward in M. Djamil General Hospital, Padang, West Sumatra, Indonesia. Through consecutive random sampling, 21 subjects were selected. The subjects’ serum NGAL and creatinine levels were acquired before PCI and 6 hours after contrast administration. Results. The mean serum NGAL and creatinine levels of the subjects before and after contrast administration were 52.26 ng/ml vs 64.78 ng/ml and 1.1 mg/dl vs 1.09 mg/dl, respectively. The serum NGAL level difference before and after contrast administration was statistically significant (p=0.003) whereas the serum creatinine level was not (p>0.005). Conclusion. There is an increase of serum NGAL levels before and after contrast administration in patient undergoing PCI, whereas serum creatinine level was not. Future studies should elaborate on the use of NGAL as an early diagnostic marker for CIN.

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“…The authors of those studies concluded that intravenous contrast administration is not a risk factor for AKI, even in patients with impaired renal function or with comorbidities that can predispose to nephrotoxicity ( 1 , 15 - 17 ) . Nevertheless, other authors have concluded that intravenous contrast administration is a risk factor for AKI in patients with CKD and diabetes mellitus ( 7 , 9 , 10 , 18 ) .…”

Section: Discussionmentioning

confidence: 97%

“…With an average incidence of 11%, CIN is recognized as the third leading cause of AKI in hospitalized patients ( 6 ) . However, the reported incidence ranges from 1% and 50%, depending on the characteristics of the population studied and whether intra-arterial or intravenous contrast is used ( 7 - 10 ) . Among patients receiving intravenous contrast alone, the reported incidence of CIN can vary from 2.5% to 12% ( 7 - 10 ) .…”

Section: Introductionmentioning

confidence: 99%

“…However, the reported incidence ranges from 1% and 50%, depending on the characteristics of the population studied and whether intra-arterial or intravenous contrast is used ( 7 - 10 ) . Among patients receiving intravenous contrast alone, the reported incidence of CIN can vary from 2.5% to 12% ( 7 - 10 ) . The classical risk factors for CIN are female gender, advanced age, diabetes mellitus, cardiovascular disease, infectious processes, chronic kidney disease (CKD), and nephrotoxic drug use ( 4 - 11 ) .…”

Section: Introductionmentioning

confidence: 99%

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Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography

et al. 2021

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Objective: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). Materials and Methods: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration. Results: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated. Conclusion: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors.

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Incidence of contrast-induced nephropathy a prospective study

Cited by 8 publications

References 27 publications

Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke

Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke

Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Creatinine Levels after Percutaneous Coronary Intervention

Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography

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