Incidence of death from kidney diseases among cancer patients: a US population-based analysis

Li, Xiaoli; Chen, Wenhui; Feng, Jinfang; Zhao, Bo

doi:10.1007/s11255-021-02801-1

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The kidney plays a crucial role in the elimination of harmful chemicals and metabolites, as well as the preservation of homeostasis 1 . One of the diseases with a high mortality rate and a life-threatening prognosis is kidney disease 2 . Failure of the kidneys is regarded as a serious health issue on a global scale 3 .…”

Section: Introductionmentioning

confidence: 99%

Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

Elbaset,

Mohamed,

Gad

et al. 2023

Sci Rep

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The kidney flushes out toxic substances and metabolic waste products, and homeostasis is maintained owing to the kidney efforts. Unfortunately, kidney disease is one of the illnesses with a poor prognosis and a high death rate. The current investigation was set out to assess erythropoietin (EPO) potential therapeutic benefits against thioacetamide (TAA)-induced kidney injury in rats. EPO treatment improved kidney functions, ameliorated serum urea, creatinine, and malondialdehyde, increased renal levels of reduced glutathione, and slowed the rise of JAK2, STAT5, AMPK, and their phosphorylated forms induced by TAA. EPO treatment also greatly suppressed JAK2, Phosphatidylinositol 3-kinases, and The Protein Kinase R-like ER Kinase gene expressions and mitigated the histopathological alterations brought on by TAA toxicity. EPO antioxidant and anti-inflammatory properties protected TAA-damaged kidneys. EPO regulates AMPK, JAK2/STAT5, and pro-inflammatory mediator synthesis.

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Section: Introductionmentioning

confidence: 99%

Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

Elbaset,

Mohamed,

Gad

et al. 2023

Sci Rep

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Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Chen

Tang

et al. 2022

Front. Pharmacol.

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Kidney injuries may trigger renal fibrosis and lead to chronic kidney disease (CKD), but effective therapeutic strategies are still limited. Quercetin is a natural flavonoid widely distributed in herbal medicines. A large number of studies have demonstrated that quercetin may protect kidneys by alleviating renal toxicity, apoptosis, fibrosis and inflammation in a variety of kidney diseases. Therefore, quercetin could be one of the promising drugs in the treatment of renal disorders. In the present study, we review the latest progress and highlight the beneficial role of quercetin in kidney diseases and its underlying mechanisms. The pharmacokinetics and bioavailability of quercetin and its proportion in herbal medicine will also be discussed.

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Incidence of death from kidney diseases among cancer patients: a US population-based analysis

Cited by 2 publications

References 21 publications

Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

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