Incidence of diabetic nephropathy in patients with type 2 diabetes mellitus at a tertiary healthcare setting in Ethiopia

Tamru, Kidist; Aga, Fekadu; Berhanie, Emebet; Aynalem, Yared Asmare; Shiferaw, Wondimeneh Shibabaw

doi:10.1016/j.dsx.2020.06.028

Cited by 10 publications

(17 citation statements)

References 28 publications

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“…To estimate the pooled prevalence of CKD stages 1 to 5 among diabetes patients, seven studies [ 31 , 48 – 53 ] were included. On the other hand, to estimate the pooled prevalence of CKD stages 3 to 5, ten studies [ 31 , 48 , 50 – 57 ] were included. Regarding the study design, the majority (75%) of the studies was cross-sectional.…”

Section: Resultsmentioning

confidence: 99%

“…The number of study participants per study ranged from 189 to 700. The included studies applied various estimators of GFR; four of the studies [ 48 , 55 – 57 ] used the CG formula in estimating GFR, four studies [ 31 , 50 , 51 , 53 ] used the MDRD, and two studies [ 52 , 54 ] used the CKD-EPI creatinine equation. The prevalence of CKD in patients with DM was obtained from various regions in Ethiopia; four studies were from Amhara [ 50 , 51 , 53 ], three from Addis Ababa [ 55 – 57 ], three from Oromia [ 48 , 49 , 52 ], one each from Tigray [ 58 ] and SNNPR [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…The included studies applied various estimators of GFR; four of the studies [ 48 , 55 – 57 ] used the CG formula in estimating GFR, four studies [ 31 , 50 , 51 , 53 ] used the MDRD, and two studies [ 52 , 54 ] used the CKD-EPI creatinine equation. The prevalence of CKD in patients with DM was obtained from various regions in Ethiopia; four studies were from Amhara [ 50 , 51 , 53 ], three from Addis Ababa [ 55 – 57 ], three from Oromia [ 48 , 49 , 52 ], one each from Tigray [ 58 ] and SNNPR [ 31 ]. With regard to the sampling technique, four studies [ 50 , 51 , 53 , 56 ] used systematic random sampling, three studies [ 31 , 57 , 58 ] used simple random sampling, two studies [ 52 , 54 ] used convenience sampling, and three studies [ 48 , 49 , 55 ] used the census sampling method.…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of CKD in patients with DM was obtained from various regions in Ethiopia; four studies were from Amhara [ 50 , 51 , 53 ], three from Addis Ababa [ 55 – 57 ], three from Oromia [ 48 , 49 , 52 ], one each from Tigray [ 58 ] and SNNPR [ 31 ]. With regard to the sampling technique, four studies [ 50 , 51 , 53 , 56 ] used systematic random sampling, three studies [ 31 , 57 , 58 ] used simple random sampling, two studies [ 52 , 54 ] used convenience sampling, and three studies [ 48 , 49 , 55 ] used the census sampling method. The quality score of the included studies was assessed based on the Newcastle–Ottawa quality score ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Based on this meta-analysis, chronic kidney disease among diabetes patients in the Ethiopian context was associated with the duration of DM, female sex, age >60 years, family history of CKD, BMI ≥30 kg/m 2 , type 2 diabetes, FBG >150 mg/dl, HbA1c >7%, HDL ≥40 mg/dl, triglyceride >150 mg/dl, and systolic blood pressure >140 mmHg [ 31 , 48 , 51 , 52 , 54 , 55 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

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Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Shiferaw

Akalu

Aynalem

2020

International Journal of Nephrology

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Background. Though different primary studies have reported the burden of chronic kidney disease among diabetes patients, their results have demonstrated substantial variation regarding its prevalence in Ethiopia. Therefore, this study aimed to estimate the pooled prevalence of chronic kidney disease and its associated factors among diabetes patients in Ethiopia. Method. PubMed, African Journals Online, Google Scholar, Scopus, and Wiley Online Library were searched to identify relevant studies. The I2 statistic was used to check heterogeneity across the included studies. A random-effects model was applied to estimate the pooled effect size across studies. A funnel plot and Egger’s regression test were used to determine the presence of publication bias. All statistical analyses were performed using STATA™ version 14 software. Result. In this meta-analysis, a total of 12 studies with 4,075 study participants were included. The estimated prevalence of CKD among diabetes patients was found to be 35.52% (95% CI: 25.9–45.45, I2 = 96.3%) for CKD stages 1 to 5 and 14.5% (95% CI: 10.5–18.49, I2 = 91.1%) for CKD stages 3 to 5. Age greater than 60 years (OR = 2.99; 95% CI: 1.56–5.73), female sex (OR = 1.68; 95% CI: 1.04–2.69), duration of diabetes >10 years (OR = 2.76; 95% CI: 1.38–5.51), body mass index >30 kg/m2 (OR = 2.06; 95% CI: 1.41–3.00), type 2 diabetes (OR = 2.54; 95% CI: 1.73–3.73), poor glycemic control (OR = 2.01; 95% CI: 1.34–3.02), fasting blood glucose >150 mg/dl (OR = 2.58; 95% CI: 1.79–3.72), high density lipoprotein >40 mg/dl (OR = 0.48; 95% CI: 0.30–0.85–25), systolic blood pressure>140 mmHg (OR = 3.26; 95% CI: 2.24–4.74), and diabetic retinopathy (OR = 4.54; CI: 1.08–25) were significantly associated with CKD. Conclusion. This study revealed that the prevalence of chronic kidney disease remains high among diabetes patients in Ethiopia. This study found that a long duration of diabetes, age>60 years, diabetic retinopathy, female sex, family history of kidney disease, poor glycemic control, systolic blood pressure, overweight, and high level of high-density lipoprotein were associated with chronic kidney disease among diabetic patients. Therefore, situation-based interventions and context-specific preventive strategies should be developed to reduce the prevalence and risk factors of chronic kidney disease among diabetes patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Shiferaw

Akalu

Aynalem

2020

International Journal of Nephrology

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Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin

Roohi,

Mehdi,

Aarfi

et al. 2023

Diabetol Int

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Diabetic Peripheral Neuropathy in Ethiopia: A Systematic Review and Meta-Analysis

Tadesse

Gebrewahd

Hailay

et al. 2021

Journal of Diabetes Research

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Background. Currently, diabetic peripheral neuropathy (DPN) is one of the most severe complications of diabetes mellitus (DM). Despite the seriousness of this problem, limited evidence is available on the prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. In Ethiopia, there were no updated studies that estimate the national prevalence of DPN. Hence, this systematic review and meta-analysis provided a national prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. Methods. This study was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) in March 2020 and accepted with the registration number CRD42020173831. Different database searching engines were searched online to retrieve related articles, including PubMed, Scopus, Google Scholar, African Journals Online, World Health Organization (WHO) Afro Library, and Cochrane Review. The reviewers used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline in the reviewing process. In this systematic review and meta-analysis, all published and unpublished articles were analyzed. The reviewers used the random effects model to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. The reviewers conducted the statistical analysis using the R version 3.5.3 and RStudio version 1.2.5033 software for Windows. The reviewers evaluated the heterogeneity across the included studies by the inconsistency index ( I 2 ). The reviewers examined the publication bias by the funnel plot. Results. The search of the databases produced 245 papers. After checking the inclusion and exclusion criteria, 38 articles with 14029 total patients with diabetes mellitus were found suitable for the review. Except for three (retrospective cohort study), all studies were cross-sectional. The overall pooled prevalence of diabetic peripheral neuropathy was 22% (95% CI 18% to 26%). The subgroup analysis of diabetic peripheral neuropathy among patients with diabetes in the different regions was 23% (95% CI 17% to 29%) in Addis Ababa, 27% (95% CI 16% to 38%) in Oromia, 16% (95% CI 14% to 18%) in South nation and nationalities, and 15% (95% CI 6% to 24%) in Amhara. Conclusions. More than one-fifth of patients with diabetes have diabetic peripheral neuropathy. According to this study, the prevalence of diabetic peripheral neuropathy in Ethiopia is considerably high. This evidence suggests that attention should be given to patients with diabetes in monitoring patients’ blood glucose.

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Incidence of diabetic nephropathy in patients with type 2 diabetes mellitus at a tertiary healthcare setting in Ethiopia

Cited by 10 publications

References 28 publications

Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis

Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin

Diabetic Peripheral Neuropathy in Ethiopia: A Systematic Review and Meta-Analysis

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