Incidence of endophthalmitis after cataract surgery in Japan

Abstract

. Purpose: To estimate the incidence rate of endophthalmitis after cataract surgery performed by Japanese surgeons. Methods: A sample of 20% of members of the Japanese Society of Ophthalmic Surgeons was randomly selected. Each member was sent a postal survey asking for information on the number of cataract surgeries performed in 2003 and the number of postsurgery cases of endophthalmitis. Results: Replies were received from 78.7% (513/652) of survey recipients. The total number of cataract surgeries was 100 539, among which 52 cases of endophthalmitis occurred, resulting in an overall incidence rate of 0.052%. Incidence rates were 0.049% (38/78 170) for scleral incision phacoemulsification and 0.043% (9/20 894) for clear corneal incision phacoemulsification, with no significant difference between groups. The average annual volumes of surgery were 210 and 280 cases for surgeons who preferred scleral incision and clear corneal incision, respectively. There was a significant difference between volumes (Student's t‐test, p < 0.01). The incidence of endophthalmitis was significantly lower with high‐volume (> 300 cases/year) surgeons than with low‐volume (≤ 300 cases/year) surgeons (0.040% versus 0.066%, chi‐square test, p < 0.05). Conclusions: The incidence of endophthalmitis after cataract surgery in Japan as estimated by a postal survey was low (0.052%) and consistent with rates reported previously. Surgeons who preferred clear corneal incision performed significantly more surgeries annually, but the incidence of endophthalmitis was similar between scleral and clear corneal incision phacoemulsification surgery.

Endophthalmitis rates after implantation of the intraocular Collamer lens: Survey of users between 1998 and 2006

“…Methods used to derive contemporary figures for the endophthalmitis rate after cataract surgery include large-scale randomized trials, 14,15 single and multicenter studies in which a prospective reporting system is used to monitor changes in endophthalmitis rates over time, 9,16 and surveys of large samples. 13 All rely on accurate diagnosis and reporting of endophthalmitis cases. 12,17 Single-center studies and randomized trials may have more robust case reporting systems 14,18 but tend to have a smaller sample size and therefore wider confidence intervals around the rate (Figure 2).…”

“…The crude rate of 1 case per 6000 implantations is less than that reported in large-scale contemporary studies of endophthalmitis after cataract surgery ( Figure 2) . [9][10][11][12][13][14] However, caution is required in the interpretation. The methodology we describe requires participating surgeons to remember cases of endophthalmitis and to respond to a survey accurately.…”

Comparison of the influence of intracameral gentamicin, gatifloxacin, and moxifloxacin on the corneal endothelium in a rabbit model

“…26 In fact, this rate compares to that in cataract surgery with intracameral cefuroxime, as shown by the ESCRS study. 1 Nevertheless, when an intracameral antibiotic is needed, the drug chosen should be as effective and safe as possible.…”

Effect of dosing interval on the efficacy of topical ophthalmic gatifloxacin against Enterococcus faecalis in an in vitro pharmacokinetic model simulating the local eye compartment

“…Rabbits received gatifloxacin three times at a given interval of 2 h in that study, whilst the effect of dosing interval remained to be investigated. An in vivo animal model is a good alternative to such rare and severe disease [12][13][14][15]; however, animals potentially differ from humans in drug absorption and defence mechanisms against pathogens. The in vitro PK model, excluding defence mechanisms, would provide conservative information also suitable for patients with an impaired immune system.…”