Incidence of Epstein-Barr Virus in Pediatric Leukemia in the Sudan

Ahmed, Hussain Gadelkarim; Osman, Shakir Idris; Ashankyty, Ibraheem

doi:10.1016/j.clml.2011.11.006

Cited by 19 publications

(26 citation statements)

References 35 publications

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“…EBV has been reported as being associated with different malignancies and its role in carcinogenesis has been proven 17–19. A high incidence of EBV in paediatric ALL has been supported by many studies 4 5 20…”

Section: Discussionmentioning

confidence: 93%

“…Ahmed et al 4 detected EBV latent membrane protein 1 (LMP1) gene transcriptional activity in a significant proportion of children with ALL.…”

Section: Discussionmentioning

confidence: 99%

“…EBV-latent membrane protein 1 (LMP1) gene transcriptional activity was observed in a significant proportion of patients with ALL 4. A high seroprevalence of EBV in paediatric ALL was observed by Loufty et al 5 and Mahjour et al 6…”

Section: Introductionmentioning

confidence: 96%

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Epstein–Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia

2016

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Section: Discussionmentioning

confidence: 93%

“…Ahmed et al 4 detected EBV latent membrane protein 1 (LMP1) gene transcriptional activity in a significant proportion of children with ALL.…”

Section: Discussionmentioning

confidence: 99%

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Epstein–Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia

2016

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“…The known causes, which are not generally factors within the control of the average person, account for relatively few cases [7]. Several studies have reported the presence of EBV DNA in the peripheral blood of patients with ALL [8,9]. Most used either peripheral blood mononuclear cells or B-lymphocytes for EBV detection and showed increased levels of EBV DNA.…”

Section: Introductionmentioning

confidence: 99%

“…Employing sensitive and specific molecular tools like Real time PCR assay, EBV LMP1 gene transcriptional activity was observed in a significant proportion of patients with acute lymphoblastic leukemia. EBV infection in patients with lymphoid leukemia may be a factor involved in the high incidence of paediatric leukemia in the Sudan [8]. A study upon Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of ALL in the offspring, (during 1983 to 2006 in Finland and 1997 to 2005 in Iceland), was carried out.…”

Section: Introductionmentioning

confidence: 99%

The Possible Involvement of Epstein -Barr virus In the Etiology of Leukemia

Elawad¹,

Kafi²

2016

J Med Microb Diagn

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Background: Although considerable brainstorm has been known into Epstein-Barr virus EBV as an important etiologic factor in various tumors, virtually little is known about the relationship between EBV genes and leukemia. The actual cause of Leukemia, which is a serious cancer in Sudan, is still under scrutiny. Controversial hypotheses were proposed suggesting the role of physical as well as chemical and even biological factors as being responsible for Leukemia incidents. We hypothesized that EBV could be involved in the etiology of leukemia. We describe here the results of our attempt to find a possible link between leukemia and EBV.Methods: Real-time Polymerase Chain Reaction assay (q-PCR) has recently been used widely for detection of Cell-free EBVDNA in the plasma of patients with leukemia. To determine the possible correlation between plasma cell-free EBV DNA levels and the leukemia, we studied the plasma EBV DNA levels in patients with leukemia that were presented at Radiation and Isotope Centre Khartoum (RICK), Sudan during therapy. The concentrations of plasma cell-free EBV DNA of 128 leukemic patients, 17 patients with EBV-associated lymphoid malignancies during the course of therapy Burkitt's lymphoma, Hodgkin's disease, Nasopharyngeal carcinoma (NPC) as control positive and 15 healthy controls were determined by using the (q-PCR) assay with the PrimerDesign™ genesig quantification kit. Results:The results revealed that EBV DNA was detectable in a wide range of leukemia patients. Plasma EBV DNA was detected in 33/88 Acute lymphoblastic leukemia (ALL) patients 28/40 Chronic myelogenous leukemia (CML),15/17 patients with EBV-associated lymphoid malignancies, but not in any of 15 healthy control subjects. The median concentration of EBV DNA in leukemia and healthy control groups was 6561.00 and 0.00 copies/ml, respectively. Conclusion:Our findings provided evidence of the involvement of EBV in patients with leukemia. The results suggested that EBV DNA genome encoding the non-glycosylated membrane protein BNRF1 pl43 was observed in a significant proportion of patients with ALL. However, we could not exclude a correlation between these viral infections and later leukemogenesis in childhood ALL in Sudan.

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Correlations between Epstein‐Barr virus and acute leukemia

Guan

Miao

Ma³

et al. 2017

Journal of Medical Virology

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Infection with Epstein-Barr virus (EBV) may be correlated to the onset of acute leukemia (AL). Studies were performed to investigate the relationship between EBV infection and immunophenotyping of acute lymphoblastic leukemia (ALL) and chromosome aberrations. Additionally, the effects of EBV on clinical prognosis were described. Fluorescence quantitative polymerase chain reaction (FQ-PCR) was used to detect EBV-DNA copy numbers from bone marrow in 110 cases of patients with ALL, 75 cases of patients with acute myeloid leukemia (AML), and 37 cases of hematologically healthy control subjects. EBV-DNA copies were found in 64 of 185 (34.6%) patients with AL and 2 of 37 healthy control subjects (P < 0.001). The EBV infection rate of ALL patients, AML patients, and healthy controls was 40.9% (45/110), 25.3% (19/75), and 5.4% (2/37), respectively. The positive rate of EBV in the ALL and AML groups was higher than in healthy subjects (P < 0.05). EBV-DNA copies were found in 1 of 12 (8.3%) T-ALLs and 44 of 98 (44.9%) B-ALLs, the positive rate of EBV in B-ALLs increased significantly compared to the rate of T-ALLs (P < 0.05). Chromosome karyotype analysis showed that EBV infection rates in B-ALL, T-ALL, and AML patients with chromosome abnormalities were 46.3% (25/54), 33.3% (1/3), and 30% (9/30), respectively. There was no statistical significance between chromosome abnormality and EBV infection (P > 0.05). In addition, EBV -ALLs had higher relapse and mortality rates than that of EBV -ALLs. Together, we conclude that EBV infection may be correlated with the incidence of AL, and the infection rate of EBV in B-ALL was higher than that of T-ALL. EBV-positive patients showed an unfavorable prognosis.

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Incidence of Epstein-Barr Virus in Pediatric Leukemia in the Sudan

Cited by 19 publications

References 35 publications

Epstein–Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia

Epstein–Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia

The Possible Involvement of Epstein -Barr virus In the Etiology of Leukemia

Correlations between Epstein‐Barr virus and acute leukemia

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