Incidence of fentanyl‐induced cough and injection speed

Hung, KN

doi:10.1111/j.1399-6576.2009.02058.x

Cited by 3 publications

(3 citation statements)

References 5 publications

(9 reference statements)

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“…On the one hand, this mechanism was speculated to directly inhibit the excitement of the medulla oblongata cough centre, thereby producing the antitussive effect. On the other hand, it may act on the trachea and bronchial tree muon through κ receptors, with suppression of the reflex tube contraction producing the antitussive effect 17,18 . These may be why oxycodone pre‐treatment in Groups III and IV reduced cough incidence when compared with the Sham group and Groups I‐II.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, it may act on the trachea and bronchial tree muon through κ receptors, with suppression of the reflex tube contraction producing the antitussive effect. 17,18 These may be why oxycodone pre-treatment in Groups III and IV reduced cough incidence when compared with the Sham group and Groups I-II.…”

Section: F I G U R E 1 Flow Diagram Of the Studymentioning

confidence: 99%

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Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl‐induced cough during induction of general anaesthesia

Dai

Cao

2020

Int J Clin Pract

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Background: Fentanyl-induced cough (FIC) usually occurs after the intravenous administration of fentanyl during general anaesthesia induction. It is a transient condition depending on the fentanyl administration dose and injection speed. Oxycodone can also prevent FIC because it has been proven to treat coughing. This study aimed to evaluate the efficacy of different oxycodone doses to prevent FIC during general anaesthesia induction. Methods: In a double-blind randomised controlled trial, 210 adult patients who were undergoing elective surgery, classified as American Society of Anaesthesiologists physical status I-II, and aged 20-65 years were randomly assigned into five equally sized groups: Sham group, Group Ⅰ, Group II, Group III and Group IV. Groups Ⅰ-IV were each intravenously injected with oxycodone 0.025, 0.05, 0.075 and 0.100 mg/ kg, while an equal volume of normal saline was given instead of oxycodone in the Sham group. Five minutes later, fentanyl 3 μg/kg was intravenously injected within 5 seconds, then, 2 minutes later the other drugs were administered for general anaesthesia induction. The occurrence and severity of coughing were observed within 2 minutes of the fentanyl injection. Vital signs and intensities of coughing were recorded and analysed. Results: Coughing incidences were each 57.1, 50, 42.8, 33.3 and 21.4% in the Sham group and Groups Ⅰ-IV. Significant differences were found in the incidences of coughing between the Sham group and Groups III-IV. No significant differences in FIC incidences have been detected between the Sham group and Groups Ⅰ-II. However, no significant difference in FIC incidence existed between Group III and Group IV. Cough severities in Groups III and IV were significantly lower than in Groups Ⅰ and II (P < .05). No significant differences existed in the hypotension or severe bradycardia incidences during anaesthesia induction among the five groups (P > .05). Conclusion: Oxycodone 0.075 mg/kg provided more effective FIC prevention during general anaesthesia induction. How to cite this article: Dai B, Cao X. Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl-induced cough during induction of general anaesthesia. Int J Clin Pract.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 1 Flow Diagram Of the Studymentioning

confidence: 99%

Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl‐induced cough during induction of general anaesthesia

Dai

Cao

2020

Int J Clin Pract

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“…24 -26 The FICreducing action of clonidine and ketamine is thought to be secondary to their sedative effects. 4,5 Non-pharmacological interventions include the huffing manoeuvre, which is a forced expiration against the open glottis, undertaken just prior to the administration of intravenous fentanyl; this was shown significantly to reduce the incidence and 27 Injection speed has also been cited as a risk factor for FIC, 6,12,28 and slow injection (> 15 s) may decrease FIC. Dilution of opioid with saline 12 and the position of the injection site (peripheral as opposed to the central route) 13 have both been shown to reduce FIC.…”

Section: Tablementioning

confidence: 99%

Effects of a Priming Dose of Fentanyl during Anaesthesia on the Incidence and Severity of Fentanyl-Induced Cough in Current, Former and Non-Smokers

Jung

et al. 2011

J Int Med Res

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Fentanyl is commonly used during anaesthesia and can cause fentanyl-induced cough (FIC). This study investigated whether a priming dose of fentanyl reduced FIC, and determined the factors associated with increased risk of FIC. Subjects undergoing elective surgery under general anaesthesia ( n = 800) were randomized into four groups: group 1 received 2 μg/kg fentanyl bolus; groups 2, 3 and 4 received a priming dose of fentanyl 0.5 μg/kg followed by 1.5 μg/kg after 1, 2 or 3 min, respectively. The incidence of FIC was 17.0%, 10.0%, 12.5% and 11.5% for groups 1, 2, 3 and 4, respectively, with no significant between-group differences in FIC incidence or severity. The mean FIC onset time was 22 s. Former smokers were 2.91 times more likely than current smokers to experience cough. A fentanyl priming dose did not reduce the incidence and severity of FIC. Former smokers were hyper-reactive to fentanyl compared with current smokers.

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Incidence of fentanyl‐induced cough and injection speed

Cited by 3 publications

References 5 publications

Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl‐induced cough during induction of general anaesthesia

Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl‐induced cough during induction of general anaesthesia

Effects of a Priming Dose of Fentanyl during Anaesthesia on the Incidence and Severity of Fentanyl-Induced Cough in Current, Former and Non-Smokers

Current awareness: Pharmacoepidemiology and drug safety

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