Incidence of Hip Fracture in Romania and the Development of a Romanian FRAX Model

Abstract

A FRAX(®) model for Romania calibrated to the total Romanian population was released June 1, 2011. This article describes the data used to develop the Romanian FRAX model and illustrates its features compared to models for other countries. Age- and sex-stratified hip fracture incidence rates and mortality rates for 2010 were extracted from nationwide databases from the age of 40 years. For other major fractures, Romanian incidence rates were imputed, using Swedish ratios for hip to other major osteoporotic fracture (humerus, forearm, and clinically symptomatic vertebral fractures). Fracture incidence rates increased with increasing age: for hip fracture, incidence rates were higher among younger men than women but with a female preponderance from the age of 65 years. The 10-year probability of hip or major fracture was increased in patients with a clinical risk factor (CRF), lower BMI, female gender, higher age, and decreased BMD T score. Of the CRFs, a parental hip fracture accounted for the greatest increase in 10-year fracture probability. The Romanian FRAX tool is the first country-specific fracture prediction model. It is based on the original FRAX methodology, which has been externally validated in several independent cohorts. Despite some limitations, the strengths make the Romanian FRAX tool a good candidate for implementation into clinical practice.

The incidence of hip fractures in Estonia, 2005–2012

“…It was higher than that recently reported in Eastern and Central European [19][20][21]28] and Western European countries [31,32,34,36,37]. The SIR in men was comparable to that in Finland, Hungary and the Czech Republic [10,15,33,38] but lower than in the group of countries with the highest incidence in Europe [10,13,14,17,29,30].…”

“…The SIR in Estonian women was lower than those recently reported in the neighbouring countries of Lithuania, Russia and Finland [15,20,21] and also lower than in many other European countries [10,11,13,14,17,18,[27][28][29][30][31][32] and US national estimates [12,35]. The difference between Estonia and other countries in SIR among Fig.…”

“…Compared to hip fracture rates from other countries, the SIR in Estonian women was low: it was comparable to that in Poland and Romania which have recently reported the lowest rates in Europe [19,28]. The SIR in Estonian women was lower than those recently reported in the neighbouring countries of Lithuania, Russia and Finland [15,20,21] and also lower than in many other European countries [10,11,13,14,17,18,[27][28][29][30][31][32] and US national estimates [12,35].…”

The Mutifactorial Pattern of Osteoporosis: A Review of the Researches of the Department of Therapy, Institute of Postgraduate Education, Yaroslavl State Medical University

“…В большинстве стран мира соотношение обратное, кроме Венгрии [12], Польши [13], Литвы [14] и Румынии [15]. Оказалось, что у мужчин в возрасте 40-69 лет достовер-но чаще, чем у более пожилых пациентов, отмечается боль-шое количество факторов риска, включая злоупотребление алкоголем, состояние алкогольного опьянения в момент травмы, курение, тяжелые физические нагрузки на протяже-нии жизни, недостаточное потребление кальция с продукта-ми питания.…”

Patterns in the Diagnosis and Treatment of Osteoporosis in Men: A Questionnaire-based Survey in Central and Eastern European Countries

“…The presented data included some perspectives and fi gures on male osteoporosis in the reporting countries [25][26][27][28][29][30][31][32]. However, the number of publications on male osteoporosis coming from the countries in Central and Eastern Europe (CEE) is still limited [33][34][35][36][37][38][39]. More information is needed to assess the patterns in the diagnosis and treatment of osteoporosis in men in those countries.…”