Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study

Park, Jongmoo; Kim, Choongrak; Ki, Yongkan; Kim, Wontaek; Nam, Jiho; Kim, Dong-Hyun; Park, Dahl; Jeon, Hosang; Kim, Dong Ho; Joo, Ji Hyeon

doi:10.1371/journal.pone.0269893

Cited by 5 publications

(7 citation statements)

References 30 publications

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“…The IMRT technique represent good option for CB sparing compare with VMAT. Patients treated with RT for breast cancer had a higher risk of developing hypothyroidism that persisted for years after treatment ended (Park et al, 2022). Based on the results of this study and the previous one .…”

Section: Discussionmentioning

confidence: 60%

A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

2023

JPTCP

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Breast cancer is the most frequent cancer among women. Surgery, chemotherapy and radiotherapy are the main aspects of breast cancer management. External beam radiotherapy has an effective role in local recurrence control. The goal of this research is to determine if the volumetric arc therapy (VMAT) technique achieved a greater advantage in terms of homogeneous dose distribution for the tumor in comparison with intensity modulated radiotherapy (IMRT) technique and also in terms of reducing the dose on organ at risk in treatment patients with right breast cancer. Patients with right-sided breast cancer who underwent modified radical mastectomy were eligible for the study. Dose volume histograms were used to examine the dose distribution for both the planning target volume and the organs at risk. VMAT plans increase dose for PTV where 95% of prescribed dose cover 95% (V95) of Chest wall (PTV C. W) when compared with IMRT plans (P-Value 0.00387). Mean dose of heart was significantly decreased in IMRT plans when compared with VMAT plans (P -Value 0.00988) . The dose distribution of VMAT plans was the same as or better than IMRT plans, and it was linked to a significant benefit in ipsilateral lung sparing (P -Value 0.00318). Based on our data, patients with right-sided breast cancer who are candidates for modified radical mastectomy may benefit more from VMAT. Our results revealed that VMAT should be the first choice for patients with right-sided breast cancer who are undergoing modified radical mastectomy.

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Section: Discussionmentioning

confidence: 60%

A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

2023

JPTCP

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“…Clinical studies have reported alteration in TH levels [ 46 , 47 ] as well as shrinkage in thyroid gland size [ 78 ] in patients undergoing or following chemotherapy. Moreover, THs can enhance the efficacy of chemotherapy [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among cancer survivors, cancer treatment-associated cardiotoxicity is a leading cause of treatment-related morbidity and mortality. In addition, studies have reported alteration in TH levels associated with cancer chemotherapy [ 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Rajagopalan

Chakraborty

Lin

2023

IJMS

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Noncoding RNAs are emerging as vital players in cardiovascular diseases. Thyroid hormones (THs) are crucial for cardiovascular survival; however, correction of systemic hypothyroidism (low serum THs) may not improve cardiac tissue-level hypothyroidism or cardiac function. Mechanistically, the understanding of noncoding transcriptomic interactions influencing TH-mediated cardiac effects is unclear. Adult C57BL/6J mixed-sex mice were randomized into Control, Hypothyroid (HypoTH), Hyperthyroid (HyperTH), and HypoTH-Triiodothyronine restoration groups. Physiological, morphological, biochemical, molecular, and whole transcriptomic studies and appropriate statistical analyses were performed. HypoTH showed significant atrophy, depressed cardiac function, and decreased serum THs versus controls, and Triiodothyronine supplementation restored them. HyperTH significantly increased serum THs with hypertrophy. Real-time PCR showed significantly altered inflammatory and immune lncRNAs. The transcriptomic sequencing revealed significant differential expressions of lncRNAs, miRNAs, and mRNAs. Eleven novel circRNAs significantly decreased with increased THs. Multiple pathways were GO-/KEGG-enriched, including cardiac, thyroid, cancer, mitochondrial, inflammatory, adrenergic, metabolic, immune-mediated, vesicular, etc. We also uncovered significant novel co-expression and interactions of lncRNA-miRNA, lncRNA-miRNA-mRNA, lncRNA-mRNA, circRNA-miRNA, and miRNA-mRNA, and splicing events. This includes a novel pathway by which the predominant cardiac TH receptor alpha may interact with specific lncRNAs and miRNAs. This is the first study reporting a comprehensive transcriptome-wide interactome in the cardiac–thyroid axis.

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“…Park et al . [ 13 ] investigated the incidence of HT after RT of about 117135 Korean BC patients with a follow-up time of 4 to 8 years. For patients treated with RT the rate of HT at 1, 5, and 8 years were 1.4, 6.2, and 9.3%, respectively, and for patients treated without RT were 1.2, 5.5, and 8.6%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism Evaluation after Radiotherapy of Breast and Supraclavicular in Patients with Breast Cancer

Karimijavid

Pashaki

Borzouei

et al. 2023

Advanced Biomedical Research

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Background: This study aims to evaluate the risk of hypothyroidism (HT) after radiotherapy (RT) of breast and supraclavicular in patients with breast cancer (BC). Materials and Methods: In a historical cohort study, the records of all patients with BC who had been referred to the Mahdieh radiotherapy Center of Hamadan from 2017 to 2019 were reviewed. Demographic characteristics, clinical information, previous and current used treatment methods (surgery, radiotherapy, chemotherapy), number of RT sessions and doses, and HT (TSH >5 mIU/L) were extracted from the patient's documents. Data were analyzed using SPSS software version 16. Results: Out of 304 patients referred to the Center, 266 patients were investigated. The mean TSH was 6.3 ± 7.9 ml/L (1.5 to 65.4). Approximately half of the patients were in Stage 2 of the disease. 37 (16.4%) patients were diagnosed with HT, of which 8.8% were clinical, and 7.5% were subclinical. The mean total dose of HT patients (5621.62 ± 491.67) was significantly higher than other patients (5304.76 ± 937.98). 21 patients (56.8%) in Stage 3 and 4 and 16 (43.2%) patients in Stages 1 and 2 had HT (P = 0.006). Spearman correlation coefficient showed that there was a significant relationship between total dose and TSH hormone (r = 0.624), the number of RT sessions with TSH hormone (r = 0.237), and total dose with T4 hormone (r = -0.232). Conclusion: The findings of this study showed that the risk of HT increases significantly in patients with BC who undergo RT of breast and supraclavicular. Patients with higher stage, more radiation, and more RT sessions are at higher risk of HT.

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Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study

Cited by 5 publications

References 30 publications

A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Hypothyroidism Evaluation after Radiotherapy of Breast and Supraclavicular in Patients with Breast Cancer

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