Incidence of Infective Hepatitis Followed by Down's Syndrome Nine Months Later

Down’s Syndrome in Fiji and Tonga

“…R -Right L -Left -Islands, an uneven distribution of cases was found which would be consistent with the viral theory of Down's Syndrqme proposed by Stoller and Collman (1965). Thus on ten islands in Central and Southern Lau visited by one of us (J.P.) in 1974 (total population approximately 9,000), all five cases of Down's Syndrome found were on two adjacent islands (Lakeba, four'…”

Studies in Down’s Syndrome I. Genetic Predisposition to Become a Carrier of the Au/SH Antigen?

“…This association was recently confirmed by Kucera [3]. Stoller and Collmann [7] suggested that the infection would be endemic, periodically epidemic and would produce only slight symptoms in affected mothers. A possible immune-body relation was also thought to be implicated.…”

“…The widespread occurrence of eczemas and other skin lesions could be particularly noticed among our patients. Depressed immunoglobulin levels in newborn infants with Down's syndrome were described by Miller et al [4], In 1957, an association between abnormal births and infections was noted by Pleydell [5], An attracting hypothesis for an association between the occurrence of Down's syndrome and infectious hepatitis, the virus being the cause of the affection of the ageing ovum, was put forward by Stoller and Collman [7]. This was based on the coincidence of infective hepatitis and the increased frequency of births of Down's infants 9 months later.…”

Seasonality of Primarily Childhood and Young Adult Infectious Diseases in the United States

“…Regional differences in the temporal pattern of each of the viral diseases explored herein are possible and should be explored in future investigations. Finally, a variety of reports have identified seasonal variation in a number of different medical conditions and phenomena, ranging from birth defects to febrile seizures in children (Manfredini et al, 2004;Siffel et al, 2005;Slater et al, 1964;Stoller and Collmann, 1965;Van Zeijl et al, 2004). The role of the seasonal patterns in infectious diseases in the etiology of these and other medical conditions that exhibit seasonality awaits more extensive assessment.…”