Incidence of inflammatory bowel disease in northern France (1988-1990).

Gower‐Rousseau, Corinne; Salomez, Jean‐Louis; Dupas, Jean Louis; Marti, Raymond; Nuttens, M C; Votte, A.; Lemahieu, M; Lemaire, B.; Colombel, Jean–Frédéric; Cortot, Antoine

doi:10.1136/gut.35.10.1433

Cited by 231 publications

(141 citation statements)

References 35 publications

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“…This is in accordance with other studies 1,8 that found a less pronounced peak-age-specific incidence in men. Moreover, in pediatric patients a higher male-to-female ratio was not demonstrated, which seems to be confined to Crohn's disease (CD).…”

Section: Discussionsupporting

confidence: 82%

Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

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Section: Discussionsupporting

confidence: 82%

Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

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“…14 In northern France, the incidence of MDS in the general population is approximately 2 to 4/10 5 , 15 and the incidence of IBD is approximately 6/10 5 . 16 Estimation of the chance for a given person to have both disorders would require knowing their prevalence in our region, which we do not. However, several features of the patients analyzed here suggest a nonfortuitous association between MDS and IBD, at least for Crohn's disease: the relatively large number of patients with both MDS and IBD; the simultaneous occurrence of IBD and MDS in seven of the 17 reported cases; some unusual features of both MDS and IBD in those patients, including relatively old age of patients for Crohn's disease, but relatively young age for MDS, and the high incidence of colonic involvement in Crohn's disease.…”

Section: Discussionmentioning

confidence: 97%

Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

et al. 1997

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We report seven patients with both myelodysplastic syndrome (MDS) and inflammatory bowel disease (IBD): Crohn's disease in six cases, ulcerative colitis in one case. We describe their characteristics, and those of 10 previously published similar cases are presented here. Median age at diagnosis of IBD (61 years) was high, as compared to the usual age at diagnosis of IBD. IBD was diagnosed first in nine cases, MDS first in one patient, and both diseases were diagnosed simultaneously in seven cases. Concerning IBD, there was a strong predominance of Crohn's disease (15/17 cases), with an unusually high frequency of colonic involvement (11/15 cases). MDS, in 12/17 cases, showed no excess of marrow blasts. Cytogenetic analysis was abnormal in five of the 13 evaluable cases. These observations suggest that the association between MDS and IBD may not be fortuitous in some cases, and that, in particular, patients with IBD and anemia of nonobvious origin should be evaluated for MDS. The pathogenesis of those associations, however, remains unclear.

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“…All diagnoses of CD, UC or indeterminate colitis were confirmed by physician reviewers from each center from primary chart reviews of endoscopy, radiology and pathology data as meeting standard diagnostic criteria. [39][40][41] Forty-three percent of pedigrees included were previously studied in one of six microsatellite linkage reports from North America, 12,[14][15][16][17]20 and results of a majority of these pedigrees were included in a single genome-wide microsatellite mega-analysis we described previously. 31 Study subjects were self-identified as white race.…”

Section: Methodsmentioning

confidence: 99%

An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29

et al. 2008

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Inflammatory bowel disease (IBD) is a complex genetic disorder of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC), with increased risk in Ashkenazi Jews. Twelve genome-wide linkage screens have identified multiple loci, but these screens have been of modest size and have used low-density microsatellite markers. We, therefore, performed a high-density single-nucleotide polymorphism (SNP) genome-wide linkage study of 993 IBD multiply affected pedigrees (25% Jewish ancestry) that contained 1709 IBD-affected relative pairs, including 919 CD-CD pairs and 312 UC-UC pairs. We identified a significant novel CD locus on chromosome 13p13.3 (peak logarithm of the odds (LOD) score ¼ 3.98) in all pedigrees, significant linkage evidence on chromosomes 1p35.1 (peak LOD score ¼ 3.5) and 3q29 (peak LOD score ¼ 3.19) in Jewish CD pedigrees, and suggestive loci for Jewish IBD on chromosome 10q22 (peak LOD score ¼ 2.57) and Jewish UC on chromosome 2q24 (peak LOD score ¼ 2.69). Nominal or greater linkage evidence was present for most previously designated IBD loci (IBD1-9), notably, IBD1 for CD families at chromosome 16q12.1 (peak LOD score ¼ 4.86) and IBD6 in non-Jewish UC families at chromosome 19p12 (peak LOD score ¼ 2.67). This study demonstrates the ability of high information content adequately powered SNP genome-wide linkage studies to identify loci not observed in multiple microsatellite-based studies in smaller cohorts.

show abstract

Incidence of inflammatory bowel disease in northern France (1988-1990).

Abstract: There were no data concerning the incidence of inflammatory bowel disease (IBD) in France.

Cited by 231 publications

References 35 publications

Ulcerative colitis in a Southern European country: A national perspective

Ulcerative colitis in a Southern European country: A national perspective

Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29

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