Incidence of keratoconus in subjects with vernal keratoconjunctivitis:

Totan, Yüksel; Hepşen, İbrahim F.; Çekıç, Osman; Gündüz, Abuzer; Aydın, Erdinç

doi:10.1016/s0161-6420(00)00664-3

Cited by 123 publications

(98 citation statements)

References 15 publications

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“…8 A study of patients with vernal keratoconjunctivitis, in Turkey, found an incidence of keratoconus, as diagnosed by videokeratography, of 26.8%. 9 A study in Dundee revealed an associated skin disorder in 34% of patients, hay fever in 36%, and asthma in 21%. 10 The incidence of atopic disease was found to be significantly higher in white patients compared to Asian patients with keratoconus.…”

Section: Discussionmentioning

confidence: 99%

Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients

Georgiou

Funnell

Cassels-Brown

et al. 2004

Eye

272

194

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Purpose To investigate the influence of ethnic origin on the incidence of keratoconus and the association of atopic diseases in patients with keratoconus. Methods Retrospective study of new patients referred to Dewsbury District General Hospital and diagnosed with keratoconus in a 6-year period between 1994 and 2000. The ethnic origin of the patient was defined as white, Asian, or other. Incidence was calculated from the catchment population of 176 774 (82% white people, 17% Asians, 1% others). t-Test, confidence intervals and v 2 tests were used to show statistical significance. Results A total of 74 cases of keratoconus were diagnosed over this period. Of these patients 29 (39%) were white and 45 (61%) were Asian. This equated to an incidence of keratoconus of 25 per 100 000 (1 in 4000) per year for Asians, compared with 3.3 per 100 000 (1 in 30 000) per year for white people (Po0.001). Asians presented significantly younger than white patients. The incidence of atopic disease was found to be significantly higher in white compared to Asian keratoconic patients. Conclusions Asians were significantly more likely to present with keratoconus. The Asian patients were mostly of Northern Pakistani origin. This community has a tradition of consanguineous, especially first-cousin marriages. The higher incidence in this population was highly suggestive of a genetic factor being significant in the aetiology. The incidence was higher than revealed by previous studies. Atopic disease was significantly less common in Asians compared to white people, supporting the theory of a different aetiology in these patients.

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Section: Discussionmentioning

confidence: 99%

Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients

Georgiou

Funnell

Cassels-Brown

et al. 2004

Eye

272

194

View full text Add to dashboard Cite

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“…Recent investigations have demonstrated that vernal conjunctivitis, classified under the term allergic conjunctivitis, is related to the abnormal pattern of the corneal surface. 6 The abnormal ocular surface deteriorates the capacity of the fluid reservoir over the ocular surface. Tear film anomalies capture allergens in the conjunctival SAC and cause the conjunctival immune-based inflammation by inducing T-cell activation.…”

Section: Discussionmentioning

confidence: 99%

Relationship between refraction and allergic conjunctivitis

Mimura

Arimoto

et al. 2007

Eye

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Purpose External allergens are the main causative factor in the pathogenesis of allergic diseases; however, little is known about internal factors such as the biometrical structure of the eye. We investigated the relationship between refractive error and allergic conjunctivitis in order to reveal possible insights into the pathogenesis in 1015 subjects. Methods The patients were divided into four groups: contact lens wearers with allergic conjunctivitis (n ¼ 73), contact lens wearers without allergic conjunctivitis (n ¼ 59), non-contact lens wearers with allergic conjunctivitis (n ¼ 224), and non-contact lens wearers without allergic conjunctivitis (n ¼ 659). The spherical power, cylindrical power, corneal radius, and minimum and maximum corneal refractive powers were measured in all subjects. Results In the non-contact lens wearers, the spherical equivalent and spherical power were significantly lower in patients with allergic conjunctivitis than in patients without allergic conjunctivitis (À3.0173.83 D vs À1.3673.08 D, Po0.0001, and À2.6473.63 D vs À1.0572.88 D, Po0.0001, respectively), while there was no significant difference in any of the parameters between the contact lens wearers with and without allergic conjunctivitis. Conclusion Refractive error may be a risk factor for allergic conjunctivitis.

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“…Although corneal changes in VKC are well documented, [7][8][9][10][11] there has been no study on corneal changes in patients with steroidinduced glaucoma and VKC using a slit scan topography system. This study was designed to study the corneal topographic changes associated with steroid-induced glaucoma in eyes with VKC and the effect of reduction in intraocular pressure on the corneal variables.…”

Section: Introductionmentioning

confidence: 99%

Corneal topographic response to intraocular pressure reduction in patients with vernal keratoconjunctivitis and steroid-induced glaucoma

Dada

Konkal

Tandon

et al. 2005

Eye

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Purpose: To study the corneal topographic response to IOP reduction in vernal keratoconjunctivitis (VKC) with steroidinduced glaucoma. Methods: A total of 42 eyes of 21 patients with VKC and steroid-induced glaucoma (Group I) and 66 eyes of 33 patients with VKC without glaucoma (Group II) underwent an evaluation by Orbscan topography. In eyes with glaucoma, the IOP was controlled medically and the corneal topography was repeated at 3 months to evaluate effect on corneal parameters. Results: The mean baseline IOP was 36.40713.08 mmHg in Group I, 14.6774.62 mmHg in Group II (Po0.0001). The IOP after treatment at 3 months follow-up was 15.0075.41 mmHg in Group I (Po0.0001). In Group I, the mean maximum Sim K decreased from 44.8673.21 D to 43.8772.62 D (P ¼ 0.031) and mean posterior corneal elevation decreased from 64.9722.36 lm to 35.7728.91 lm at 3 months after reduction of IOP (P ¼ 0.001). There was a significant positive correlation between the reduction in the IOP and the decrease in the posterior corneal elevation (r ¼ 0.664, P ¼ 0.001). Conclusion: Eyes with VKC with and without glaucoma have similar corneal topography. Increased IOP associated with steroid-induced glaucoma and VKC may contribute to an increase in the corneal curvature and posterior corneal elevation. These changes may be reversed by a reduction in the IOP with medical therapy.

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Incidence of keratoconus in subjects with vernal keratoconjunctivitis:

Cited by 123 publications

References 15 publications

Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients

Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients

Relationship between refraction and allergic conjunctivitis

Corneal topographic response to intraocular pressure reduction in patients with vernal keratoconjunctivitis and steroid-induced glaucoma

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