Incidence of Leukocytoclastic Vasculitis in Chronic Idiopathic Urticaria; Study of 100 Cases

Peteiro, C.; Toribio, Jaime

doi:10.1097/00000372-198912000-00003

Cited by 33 publications

(27 citation statements)

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“…In angioedema, similar changes occur primarily in the lower dermis and the subcutis. Skin affected by wheals virtually always exhibits upregulation of endothelial cell adhesion molecules, neuropeptides and growth factors and a mixed inflammatory perivascular infiltrate of variable intensity, consisting of neutrophils with or without eosinophils, basophils, macrophages and T cells but without vessel‐wall necrosis, which is a hallmark of urticarial vasculitis . The nonlesional skin of chronic spontaneous urticaria (CSU) patients shows upregulation of adhesion molecules, infiltrating eosinophils and altered cytokine expression .…”

Section: Definitionmentioning

confidence: 99%

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Zuberbier

Aberer

Asero

et al. 2018

Allergy

1,368

1,953

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This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and other chronic forms of urticaria are disabling, impair quality of life and affect performance at work and school. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. In addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

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Section: Definitionmentioning

confidence: 99%

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Zuberbier

Aberer

Asero

et al. 2018

Allergy

1,368

1,953

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show abstract

“…Na obszarze skóry, w obrębie której rozwijają się bąble pokrzywkowe, prawie zawsze dochodzi do zwiększenia ekspresji cząsteczek przylegania komór kowego w śródbłonku oraz powstania okołonaczy niowego mieszanego nacieku zapalnego. Nasilenie stanu zapalnego bywa zmienne, a skład komórkowy obejmuje neutrofile, eozynofile, makrofagi oraz lim focyty T. Nie stwierdza się natomiast martwicy ściany naczyń, co jest charakterystyczne dla pokrzywki na czyniowej (urticaria vasculitis) [12][13][14]. Niektórzy au torzy donoszą także o łagodnym do umiarkowanego zwiększeniu liczby komórek tucznych.…”

Section: Aspekty Patofizjologiczneunclassified

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Zuberbier¹,

Aberer²,

Asero³

et al. 2015

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“…These methods imply the cons of being time and cost-consuming and invasive, in case of performing routine biopsies. Histopathologically, the essential criteria for the diagnosis of UV is the presence of karyorrhexis (nuclear dust), joined by extravasated erythrocytes and, at time, by fibrin deposits within 6,20,21 . Vascular fibrinoid necrosis is considered rare or absent in UV.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular fibrinoid necrosis is considered rare or absent in UV. Biopsy timing (optimally within the first 24-48 hours) is important to achieve a characteristic picture of UV 20,21 .…”

Section: Discussionmentioning

confidence: 99%

“…Dermoscopic examination preceded biopsy, and both were performed on the same urticariform lesions. Since vasculitis is a dynamic process, and the most characteristic histological features develop in more recent lesions (neutrophils, haemorrhage, and leukocytoclasia) 21 , biopsies were taken from lesions less than 24 hours old. The lower leg location was excluded in order to avoid histological changes caused by venous stasis.…”

Section: Patients Methods and Definitionsmentioning

confidence: 99%

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Development of a clinical-dermoscopic model for the diagnosis of urticarial vasculitis

García-García

Aubán-Pariente

Munguía-Calzada

et al. 2020

Sci Rep

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the clinical criteria for the diagnosis of urticarial vasculitis lack accuracy, according to previous studies. the aim of the study was to assess the accuracy of a clinical and a clinical-dermoscopic model for the differential diagnosis of chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV). Dermoscopic images of lesions with histopathologically confirmed diagnosis of CSU and UV were evaluated for the presence of selected criteria (purpuric patches/globules (PG) and red linear vessels). Clinical criteria of CSU and UV were also registered. Univariate and adjusted odds ratios were calculated. Multivariate regression analyses were conducted separately for clinical variables (clinical diagnostic model) and for both clinical and dermoscopic variables (clinical-dermoscopic diagnostic model). 108 patients with CSU and 27 patients with UV were included in the study. The clinical-dermoscopic model notably showed higher diagnostic sensitivity than the clinical approach (63% vs. 44%). Dermoscopic purpuric patches/globules (PG) was the variable that better discriminated UV, increasing by 19-fold the odds for this diagnosis. In conclusion, dermoscopy helps the clinical discrimination between CSU and UV. The visualization of dermoscopic pG may contribute to optimize decisions regarding biopsy in patients with urticarial rashes.The aim of this study was to investigate the value of dermoscopy for the differential diagnosis of urticariform rashes of CSU and UV, and to evaluate the accuracy of a clinical-dermoscopic diagnostic model versus a clinical approach for discriminating both diseases. Scientific RepoRtS |(2020) 10:6092 | https://doi.

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Incidence of Leukocytoclastic Vasculitis in Chronic Idiopathic Urticaria; Study of 100 Cases

Cited by 33 publications

References 0 publications

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Development of a clinical-dermoscopic model for the diagnosis of urticarial vasculitis

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