Incidence of Liver Tumors in Male and Female Rats Fed Carcinogenic Azo Dyes

Mulay, A. S.; O’Gara, Roger W.

doi:10.3181/00379727-100-24613

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“…These varied in their time of appearance, tending to occur later than the peak of binding of o-AAT, and also in their magnitude. There does not appear to be a previous report of a difference between the sexes in the formation of bound dye, although 4-dimethylaminoazobenzene, one of the dyes used in similar studies (Roberts & Warwick, 1966), is a more potent liver carcinogen in male rats than in female rats (Mulay & O'Gara, 1959).…”

Section: Resultsmentioning

confidence: 90%

The binding of o-aminoazotoluene to deoxyribonucleic acid, ribonucleic acid and protein in the C57 mouse

Lawson

1968

Biochemical Journal

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1. (3)H-labelled o-aminoazotoluene was synthesized from [G-(3)H]o-toluidine on a semi-micro scale. 2. An association of (3)H with DNA, RNA and protein from the liver, kidney and spleen of female C57b mice was demonstrated after the administration of a single dose of [(3)H]o-aminoazotoluene. 3. This association is judged to represent covalent binding as a result of experiments involving solvent extraction, examination of the acid hydrolysates of the DNA and RNA and administration of [(3)H]water with unlabelled o-aminoazotoluene. 4. Examination of the extents of binding at various times after the administration of a single dose of [(3)H]o-aminoazotoluene showed that there was a peak of binding to liver DNA in the female mice at about 16hr. that was not present in the male mice. 5. The extent of binding to DNA, RNA and protein at 16hr. in the female C57b mouse liver was greater than that in the spleen and kidney.

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Section: Resultsmentioning

confidence: 90%

The binding of o-aminoazotoluene to deoxyribonucleic acid, ribonucleic acid and protein in the C57 mouse

Lawson

1968

Biochemical Journal

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show abstract

Incidence of Liver Tumors in Male and Female Rats Fed Carcinogenic Azo Dyes

Cited by 1 publication

References 0 publications

The binding of o-aminoazotoluene to deoxyribonucleic acid, ribonucleic acid and protein in the C57 mouse

The binding of o-aminoazotoluene to deoxyribonucleic acid, ribonucleic acid and protein in the C57 mouse

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