Incidence of lower limb amputations in individuals with and without diabetes mellitus in Andalusia (Spain) from 1998 to 2006

Temporal trends in initial and recurrent lower extremity amputations in people with and without diabetes in Western Australia from 2000 to 2010

“…Our observation that a decreasing incidence of major lower extremity amputations is driving the overall fall in total amputations is consistent with most epidemiological studies from Europe and the US [6,8,9,14,21] although some studies found no change in major amputation rates [22,23].…”

Decrease in Major Amputations in Germany

“…Poisson regression analysis showed no statistically significant change in diabetes‐related amputation incidence over time [0·98 decrease per year (95% CI: 0·93–1·02); P = 0·12] . A Spanish analysis did not report a decrease in the incidence of lower limb amputation in Andalusia from 1998 to 2006 in the population with and without diabetes . In the population with diabetes, the standardised incidence of all lower‐limb amputation was found to be 34·0 per 10 000 (95% CI: 31·5–37·2) in 2004–2006.…”

“…In recent years, data has been published presenting promising statistics of decreasing amputation rates in the USA . A small variation in rate was reported from the UK , but not in Spain and Australia . Thus, we were interested to see the recent trends in Germany.…”

Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?

“…The prevalence of an ABI < 0.9 in series of Spanish patients with diabetes ranges from 21% to 60% (Table 1) [8, 24,25] . In the autonomous communities of Andalusia and the Canary Islands, 72% of all lower-limb amputations between 1996 and 2006 involved patients with diabetes [23,26,27] . In patients with diabetes, for every 1% increase in haemoglobin A1c there is a corresponding 26% increased risk of PAD [28] .…”