Incidence of Lyme Borreliosis in Europe: A Systematic Review (2005–2020)

Burn, Leah; Vyse, Andrew; Pilz, Andreas; Tran, Thao Mai Phuong; Fletcher, Mark A.; Angulo, Frederick J.; Gessner, Bradford D.; Moïsi, Jennifer C; Stark, James H.

doi:10.1089/vbz.2022.0070

Cited by 29 publications

(28 citation statements)

References 67 publications

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“…Data presented in review [4] indicate that the incidence of LB disease in Europe is substantial but geographically heterogeneous, both among and within countries. Data reported at the national level can often mask subnational differences, particularly in areas with substantially higher incidences.…”

Section: Lyme Disease In Slovakia and Norwaymentioning

confidence: 99%

Bacterial Vector-Borne Zoonotic Diseases and One Health Approach. A Review

Aasegg,

Kostičák,

Ondrejková

et al. 2023

Folia Veterinaria

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One Health is a collaborative, multisectoral, and transdisciplinary approach with the goal of achieving optimal health outcomes recognizing the interconnection between people, animals, plants, and their shared environments. The main goal of this paper is to highlight the significance of the One Health concept in relation to the large group of diseases that transmits through arthropods and their worldwide distribution, with a closer look at the zoonoses. The importance of knowledge increases as the globalization and climate changes increases the likelihood of transmission, as both cause favourable conditions for transmission of bacteria and viruses. The increase in reservoir abundance, climate change, changing habitat structure, socio-political changes, and import of animals for welfare reasons, trade and traveling are considered to be potential factors for the pathogen and vector introductions to new areas. This article highlights the selected agents of bacterial zoonoses as sources of human and animal diseases and shows the number of cases of Lyme disease, which is the most common bacterial tick-borne disease in humans in Slovakia and Norway, and the trend in incidence over the past twelve years.

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Section: Lyme Disease In Slovakia and Norwaymentioning

confidence: 99%

Bacterial Vector-Borne Zoonotic Diseases and One Health Approach. A Review

Aasegg,

Kostičák,

Ondrejková

et al. 2023

Folia Veterinaria

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“…In contrast, the Czech Republic, Germany, Poland, Scotland, Belarus, Croatia, Denmark, France, Ireland, Portugal, Russia, Slovakia, Sweden and the United Kingdom reported incidence rates of less than 40/100,000 PPY. (Burn et al., 2023)…”

Section: Introductionmentioning

confidence: 99%

Discrepancy between IDSA and ESGBOR in Lyme disease: Individual participant meta‐analysis in Türkiye

Yıldız,

Çetin,

Pınarlık

et al. 2024

Zoonoses and Public Health

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BackgroundThe evidence on the prevalence of Lyme borreliosis (LB) is limited, but there is a suspicion of overdiagnosis of LB in recent years. We reviewed the LB diagnosis and treatment‐related data in Türkiye, based on the Infectious Diseases Society of America (IDSA) 2020 and European Society of Clinical Microbiology and Infectious Diseases Study Group for Lyme Borreliosis (ESGBOR) 2018 guidelines. By detecting the disagreements between these two, we outlined the areas to be improved for future guidelines.MethodsWe performed a literature search according to the PRISMA guidelines in PubMed, Ovid‐Medline, Web of Science, Turkish Medline, Scopus, CINAHL, ULAKBIM TR Index, Google Scholar and Cochrane Library databases. We included the published cases in a database and evaluated according to IDSA and ESGBOR guidelines. We outlined the reasons for misdiagnoses and inappropriate uses of antibiotics.ResultsWe included 42 relevant studies with 84 LB cases reported from Türkiye between 1990 and December 2022. Among 84 cases, the most common clinical findings were nervous system findings (n = 37, 44.0%), erythema migrans (n = 29, 34.5%) and ophthalmologic findings (n = 15, 17.9%). The IDSA 2020 and ESGBOR 2018 guidelines agreed on the diagnosis of 71 (84.5%) cases; there was an agreement that 31 cases (36.9%) were misdiagnosed and 40 cases (47.6%) were correctly diagnosed, and there was disagreement for 13 cases (15.5%). Serum immunoglobulin M (IgM), IgG measurements by ELISA and western blot were widely performed, and they were effective in definitive diagnosis merely when used according to guidelines. Inappropriate use of antibiotics was detected in 42 (50.0%) of cases which were classified in the following categories: incorrect LB diagnosis, inappropriate choice of antibiotic, inappropriate route of drug administration and prolonged antibiotic treatment.ConclusionOverdiagnosis and non‐adherence to guidelines is a common problem. The discordance between seroprevalence and clinical studies necessitates a consensus over the best clinical approach.

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“…Current methods to diagnose Lyme disease and other TBIs can be insufficient [ 11 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Lyme disease diagnosis is supported by patient history, clinical examination findings, and completing serology tests [ 11 , 23 , 24 , 25 ]. However, patients often cannot remember receiving tick bites or do not develop a bull’s eye rash [ 11 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Scrutinizing Clinical Biomarkers in a Large Cohort of Patients with Lyme Disease and Other Tick-Borne Infections

Xi,

Garg,

Lambert

et al. 2024

Microorganisms

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Standard clinical markers can improve tick-borne infection (TBI) diagnoses. We investigated immune and other clinical biomarkers in 110 patients clinically diagnosed with TBIs before (T0) and after antibiotic treatment (T2). At T0, both the initial observation group and patients without seroconversion for tick-borne pathogens exhibited notably low percentages and counts of CD3 percentage (CD3%), CD3+ cells, CD8+ suppressors, CD4 percentage (CD4%), and CD4+ helper cells, with the latter group showing reductions in CD3%, CD3+, and CD8+ counts in approximately 15-22% of cases. Following treatment at the T2 follow-up, patients typically experienced enhancements in their previously low CD3%, CD3+ counts, CD4%, and CD4+ counts; however, there was no notable progress in their low CD8+ counts, and a higher number of patients presented with insufficient transferrin levels. Moreover, among those with negative serology for tick-borne infections, there was an improvement in low CD3% and CD3+ counts, which was more pronounced in patients with deficient transferrin amounts. Among those with CD57+ (n = 37) and CD19+ (n = 101) lymphocyte analysis, 59.46% of patients had a low CD57+ count, 14.85% had a low CD19 count, and 36.63% had a low CD19 percentage (CD19%). Similar findings were observed concerning low CD57+, CD19+, and CD19% markers for negative TBI serology patients. Overall, this study demonstrates that routine standard clinical markers could assist in a TBI diagnosis.

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Incidence of Lyme Borreliosis in Europe: A Systematic Review (2005–2020)

Cited by 29 publications

References 67 publications

Bacterial Vector-Borne Zoonotic Diseases and One Health Approach. A Review

Bacterial Vector-Borne Zoonotic Diseases and One Health Approach. A Review

Discrepancy between IDSA and ESGBOR in Lyme disease: Individual participant meta‐analysis in Türkiye

Scrutinizing Clinical Biomarkers in a Large Cohort of Patients with Lyme Disease and Other Tick-Borne Infections

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