Incidence of major cardiovascular events at 1, 2, 5 years and mortality in incident patients on peritoneal dialysis regarding their nutritional status by bioimpedanciometry. A multicenter study in Colombia

Abstract

Background: The nutritional status of incident patients on peritoneal dialysis (PD) has been associated with survival outcomes. Bioimpedanciometry (BCM) enables to establish a nutritional diagnosis, the volume status, and correlates these findings with survival (1). Methods: Retrospective multicenter historical cohort study. Results: In this study, which included 420 incident patients on peritoneal dialysis with a 5-year follow-up, a cumulative incidence of major adverse cardiovascular events (MACE) of 28.8% was found; being higher in the diabetic population at 36.8%. In regard to the nutritional status in this population, it was found that approximately 44% had altered nutritional status; 34% were found to be in sarcopenia, 6.7% sarcopenic obesity; and 2.8% in obesity (p < 0.001). In the survival analysis, a lower probability of survival was found in patients with overhydration (OH) greater than 3 liters (p<0.001) and in patients with altered nutritional status due to sarcopenia, sarcopenic obesity, and obesity (p 0.016). According to survival in the subgroup of the diabetic population, a lower probability of survival was found in this group of patients (p:0.011); The overall mortality of the study population was 18%, being higher in the first 2 years; thus finding that the most important causes of mortality were cardiovascular. Of the deceased population, 51% were diabetic patients (p:0.012) Conclusion: In incident patients on peritoneal dialysis, sarcopenic obesity, sarcopenia, overhydration status determined by BCM, and having a diagnosis of diabetes are related to a lower probability of survival; MACE outcomes are more frequent in the diabetic population.