Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-dwelling Women and Men

Shang, Xianwen; Peng, Wei; Hill, Edward; Szoeke, Cassandra; He, Miao; Zhang, Lei

doi:10.1016/j.eclinm.2019.08.010

Cited by 26 publications

(12 citation statements)

References 32 publications

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“…Similar to other surveys [ 3 , 41 ], both KOA and DS are very common among middle-aged and older people, especially among females. However, gender was not identified as a mediator in the relationship between KOA and DS in this research, which is consistent with another longitudinal study [ 30 ]. And we found no mediating effect of age, either.…”

Section: Discussionsupporting

confidence: 90%

“…Nicola et al reported that the incidence of DS associated with KOA was 26 per 1000 person-years, KOA patients were more likely to develop DS (odds ratio, = 1.43: 95% CI = 1.03 to 1.98) [ 29 ]. Another study analyzing the association of cancer, cardiovascular disease, diabetes, and OA at baseline with incident depression found that among these four conditions OA had the highest risk for incident depression (HR = 1.94: 95% CI = 1.80 to 2.10) [ 30 ]. However, most of the existing research samples have come from high-income countries, whereas our research provides evidence from China.…”

Section: Discussionmentioning

confidence: 99%

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Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort

Han

Wang

Zhou

et al. 2022

BMC Musculoskelet Disord

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Background Both knee osteoarthritis (KOA) and depressive symptoms (DS) are major public health issues affecting the quality of life. This study aimed to examine the association between KOA and DS. Methods Data were gathered from the China Health and Retirement Longitudinal Study in 2011–2015 which surveyed middle-aged to elderly individuals and their spouses in 28 provinces in China. An adjusted Cox proportional hazards regression model was used to estimate hazard ratios (HRs). Results The analysis for baseline KOA and the subsequent risk of DS was based on 2582 participants without baseline DS. During the follow-up, KOA patients were more likely to have DS than non-KOA participants (adjusted HR = 1.38: 95% CI = 1.23 to 1.83). The analysis for baseline DS and the subsequent risk of KOA was based on 4293 participants without baseline KOA, those with DS were more likely to develop KOA than non-DS participants (adjusted HR = 1.51: 95% CI = 1.26 to 1.81). Subgroup analysis showed sex and age had no significant moderating effect on the KOA-DS association. Conclusions Our results provide evidence that the association between KOA and DS is bidirectional. Therefore, primary prevention and management of KOA and DS should consider this relationship.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort

Han

Wang

Zhou

et al. 2022

BMC Musculoskelet Disord

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“…The relationship of mental disorders with osteoarthritis (28), cardiometabolic disorders (29), cancer (30), dementia (31), and Parkinson's disease (32,33) has been reported in previous studies. Chronic pain, disability, adverse effects on lifestyle as well as the he perceived loss of health, functional capability and independence in patients with these physical chronic diseases may partly explain the increased risk of mental disorders (34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 71%

Incidence, Progression, and Patterns of Multimorbidity in Community-Dwelling Middle-Aged Men and Women

Shang

Peng

Hill

et al. 2020

Front. Public Health

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Background: Determining the incidence, progression, and patterns of multimorbidity are important for the prevention, management, and treatment of concurrence of multiple conditions. This study aimed to analyze major multimorbidity patterns and the association of the onset of a primary condition or combinations of a primary and a secondary condition with the progression to subsequent conditions. Methods: We included 53,867 participants aged 45-64 years from the 45 and Up Study who were free of 10 predefined chronic conditions at baseline (2006-2009). The incidence of multimorbidity (coexistence of ≥2, ≥3, and ≥4 conditions) was identified using the claims database until December 31, 2016. The primary, secondary, tertiary, and quaternary condition for each participant was defined according to its temporal order of onset. Results: During a mean 9-years follow-up, the cumulative incidence of primary, secondary, tertiary, and quaternary conditions was 49.6, 23.7, 9.0, and 2.9%, respectively. The time to develop a subsequent condition decreased with the accumulation of conditions (P < 0.0001). Two concurrent cardiometabolic disorders (CMDs, 30.4%) and CMDs clustered with musculoskeletal disorders (15.2%), mental disorders (13.5%), asthma (12.0%), or cancer (8.7%) were the five most common multimorbidity patterns. CMDs tended to occur prior to mental or musculoskeletal disorders but after the onset of cancers or asthma. Compared with all participants who developed cancer as a primary condition, individuals who experienced mental disorders/neurodegenerative disorders and a comorbidity as cardiovascular disease, hypertension, dyslipidemia, diabetes, asthma, or osteoarthritis were 3.36-10.87 times more likely to develop cancer as a tertiary condition. Individuals with neurodegenerative disorders and a comorbidity as hypertension, dyslipidemia, osteoarthritis, or asthma were 5.14-14.15 times more likely to develop mental disorders as a tertiary condition. Shang et al. Incidence, Progression, Patterns of Multimorbidity Conclusions: A high incidence of multimorbidity in middle-aged adults was observed and CMDs were most commonly seen in multimorbidity patterns. There may be accelerated aging after a primary condition occurs. Our findings also reveal a potential preventative window to obviate the development of secondary or tertiary conditions.

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“…In many developed countries, including Scotland [ 6 ], Canada [ 7 ], UK [ 8 ], Denmark [ 9 ], Sweden [ 10 ], Australia [ 11 ] and USA [ 12 ], type 2 diabetes-related mortality has declined steadily. People living with type 2 diabetes are at higher risk of chronic diseases, viral hepatitis and even COVID-19 severity [ 13 – 16 ]. However, large developing economies such as China reported an ongoing and increasing trend of diabetes mellitus, with diabetes mortality increasing from 5.3 deaths/100,000 people in 1990 to 10.9 deaths/100,000 people in 2017 [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data

et al. 2022

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Aims/hypothesis The study aims to quantify the global trend of the disease burden of type 2 diabetes caused by various risks factors by country income tiers. Methods Data on type 2 diabetes, including mortality and disability-adjusted life years (DALYs) during 1990–2019, were obtained from the Global Burden of Disease Study 2019. We analysed mortality and DALY rates and the population attributable fraction (PAF) in various risk factors of type 2 diabetes by country income tiers. Results Globally, the age-standardised death rate (ASDR) attributable to type 2 diabetes increased from 16.7 (15.7, 17.5)/100,000 person-years in 1990 to 18.5 (17.2, 19.7)/100,000 person-years in 2019. Similarly, age-standardised DALY rates increased from 628.3 (537.2, 730.9)/100,000 person-years to 801.5 (670.6, 954.4)/100,000 person-years during 1990–2019. Lower-middle-income countries reported the largest increase in the average annual growth of ASDR (1.3%) and an age-standardised DALY rate (1.6%) of type 2 diabetes. The key PAF attributing to type 2 diabetes deaths/DALYs was high BMI in countries of all income tiers. With the exception of BMI, while in low- and lower-middle-income countries, risk factors attributable to type 2 diabetes-related deaths and DALYs are mostly environment-related, the risk factors in high-income countries are mostly lifestyle-related. Conclusions/interpretation Type 2 diabetes disease burden increased globally, but low- and middle-income countries showed the highest growth rate. A high BMI level remained the key contributing factor in all income tiers, but environmental and lifestyle-related factors contributed differently across income tiers. Data availability To download the data used in these analyses, please visit the Global Health Data Exchange at http://ghdx.healthdata.org/gbd-2019. Graphical abstract

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Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-dwelling Women and Men

Cited by 26 publications

References 32 publications

Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort

Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort

Incidence, Progression, and Patterns of Multimorbidity in Community-Dwelling Middle-Aged Men and Women

Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data

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