Incidence of medulloblastoma in Canadian children

Johnston, Donna L.; Keene, Daniel; Kostova, Maria; Strother, Douglas; Lafay‐Cousin, Lucie; Fryer, Chris; Scheinemann, Katrin; Carret, Anne‐Sophie; Fleming, Adam; Percy, Vanessa; Afzal, Samina; Wilson, Beverly; Bowes, Lynette; Zelcer, Shayna; Mpofu, Chris; Silva, Mariana; Larouche, Valérie; Brossard, Josée; Bouffet, Éric

doi:10.1007/s11060-014-1588-x

Cited by 16 publications

(11 citation statements)

References 9 publications

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“…For both authors, medulloblastoma incidence remained stable. [8] The probable cause of this improvement in outcome is unclear, though one should consider a number of points: better access to health care, faster initial diagnosis, greater recruitment into clinical trials, alternatives of adjuvant therapy, aggressiveness of management initially and at relapse, and better supportive care and improvement in RT and imaging technology.…”

Section: Discussionmentioning

confidence: 99%

Survival and prognostic factors in childhood medulloblastoma: A Brazilian single center experience from 1995 to 2016

Bleil¹,

Bizzi

Bedin³

et al. 2019

Surgical Neurology International

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Background: Medulloblastoma is the most common malignant brain tumor in the pediatric population. Despite prognosis improvement in the past two decades, one-third of the patients still remain incurable. New evidence suggests that medulloblastoma comprises four distinct entities; therefore, treatment de-escalation is required. The aim of this article is to evaluate epidemiological data from patients treated at our institution. The primary objective is to analyze overall survival (OS) and event-free survival (EFS) and the secondary objective is to identify prognostic factor from this cohort. Methods: We retrospectively analyzed 69 patients who underwent surgical resection for medulloblastoma among 423 children from the tumor registry data bank of Santo Antônio Children’s Hospital from 1995 to 2016. Kaplan–Meier method and Cox regression analysis were used to identify OS, EFS, and prognostic factors. Results: The 5-year OS and EFS rates found were 44.5% and 36.4%, respectively. The extent of resection and radiotherapy as adjuvant treatments was positively correlated to outcome while metastatic disease at diagnosis was negatively related to OS. Age younger than 3 years old did not have a worse outcome in our cohort. Conclusion: Similar results to population-based studies were found, but we still face difficulties due to living in a developing country. In the near future, we look forward to new diagnostic techniques that will enable us to classify medulloblastomas according to molecular subgroups.

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Section: Discussionmentioning

confidence: 99%

Survival and prognostic factors in childhood medulloblastoma: A Brazilian single center experience from 1995 to 2016

Bleil¹,

Bizzi

Bedin³

et al. 2019

Surgical Neurology International

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“…The overall annual incidence rate is approximately 5 cases per million, which does not vary substantially across ethnicities or geographical regions [19,20]. The male to female ratio is 1.8:1 [21,22]. A wide range of syndromes like Gorlin syndrome, FAP syndrome, ataxia-telangiectasia, Bloom syndrome, Fanconi's anemia, Li-Fraumeni syndrome and Xeroderma pigmentosum have been implicated in MB pathogenesis [23].…”

Section: Epidemiology and Geneticsmentioning

confidence: 99%

Pediatric Brain Tumors: From Modern Classification System to Current Principles of Management

Ozair¹,

Khan²,

Bhat³

et al. 2022

Central Nervous System Tumors

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Central nervous system (CNS) malignancies contribute significantly to the global burden of cancer. Brain tumors constitute the most common solid organ tumors in children and the second most common malignancies of childhood overall. Accounting for nearly 20% of all pediatric malignancies, these are the foremost cause of cancer-related deaths in children 0–14 years of age. This book chapter provides a state-of-the-art overview of pediatric brain tumors. It discusses their morbidity and mortality and introduces the WHO 2021 classification of CNS tumors, which is critical to therapeutic decision-making. It then describes the modern understanding of tumor grading and its clinical implications, followed by the general principles of diagnosis and management. The chapter then discusses, in detail, those brain tumors which have the highest disease burden in children, including medulloblastoma, astrocytoma, ependymoma, schwannoma, meningioma, amongst others. The landscape of treatment of pediatric brain tumors has been rapidly evolving, with several effective therapies on the horizon.

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“…[ 1 2 ] Its current prognosis, compared to other central nervous system neoplasms, is superior with 30-year overall survival (OS) of 70.2%. [ 3 ] Tumor removal surgery and cerebrospinal fluid (CSF) diversion, together with radio- and chemotherapy, are the current standard management of medulloblastoma, with the dosages of the latter two being determined through postsurgical risk stratification. [ 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with post-therapeutic outcome for medulloblastoma: An experience from Indonesia

et al. 2021

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Context: The prognosis of medulloblastoma is better in patients who underwent complete treatment consisting of surgery, radiotherapy, and chemotherapy. However, the realization of such multidiscipline management is quite challenging in developing countries, including Indonesia. Until now, no study on the management of medulloblastoma has ever been conducted in Indonesia. Aims: The authors aimed to study the characteristics, management, and mortality outcome of medulloblastoma patients in Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia. Subjects and Methods: This study was based on medical record and registry of 44 medulloblastoma patients who underwent tumor removal in Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia, between 2011 and 2018. Statistical Analysis Used: Cox regression analysis was utilized to determine the relationship between patients' demography, tumor characteristics, and treatment, with mortality. Results: The incidence of mortality was 84.1% and median months' survival time (95% confidence interval [CI]) was 13 (8.67–17.32). Gross total removal (GTR) was performed in 43.2% of all tumor removal surgery. Only 50% of all patients completed radiotherapy, and 6.8% concluded multimodalities treatment (surgery, radiotherapy, and chemotherapy). Significant statistical association between age, gender, and extent of resection with mortality was identified (HR [95% CI] for age: 0.44 [0.22–0.88], gender: 0.001 [0.000–0.27; REF: female], and biopsy: 31.52 [1.09–910.56; REF: GTR]). Conclusions: The survival rate of medulloblastoma in Indonesia is inferior to that previously reported in other studies. There is no unusual characteristic contributing to neoteric risk factor. The authors surmise that insufficient multidisciplinary management for the disease, consisting of suboptimal tumor resection, the absence of risk stratification, and incomplete postsurgical treatment (radiotherapy and chemotherapy) resulted in such outcome.

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Incidence of medulloblastoma in Canadian children

Cited by 16 publications

References 9 publications

Survival and prognostic factors in childhood medulloblastoma: A Brazilian single center experience from 1995 to 2016

Survival and prognostic factors in childhood medulloblastoma: A Brazilian single center experience from 1995 to 2016

Pediatric Brain Tumors: From Modern Classification System to Current Principles of Management

Risk factors associated with post-therapeutic outcome for medulloblastoma: An experience from Indonesia

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