Incidence of multiple sclerosis in Iceland, 2002–2007: a population-based study

Elíasdóttir, Ólöf; Ólafsson, Elías; Kjartansson, Ólafur

doi:10.1177/1352458511402112

Cited by 14 publications

(13 citation statements)

References 12 publications

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“…Of the 37 reports, four were used for comparing age-specific incidence only [35,37,40,48], 16 provided data for studying trends [19,21,27,28,41,43,49-58] and seven could be used for both purposes [8,10,31,32,34,36,47]. Ten studies were excluded [24,26,30,33,38,39,42,46], [59,60], four due to incidences calculated from data sets based on age at diagnosis, i.e., explicitly reporting MS diagnoses instead of clinical onsets [30,33,46,60]. The geographical distribution of studies selected for each purpose is depicted in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, for reports not yet definitely excluded on the basis of criteria defined in subsection 1.a. above, the authors of 13 surveys [30-35,37-42,46] were requested to furnish such data in a different format, e.g., age at clinical onset instead of age at MS diagnosis, or distribution by age of incident MS case different to that shown. Subsequently, new case-related data were obtained from five surveys [30-32,37,40] or completed with data extracted from graphs, specifically from four of them deemed useful for combination [31,32,37,40].…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently, new case-related data were obtained from five surveys [30-32,37,40] or completed with data extracted from graphs, specifically from four of them deemed useful for combination [31,32,37,40]. For 12 surveys, the population structure in new age-groups or complementary demographic data were obtained from the authors or official statistics bodies [8,30-37,40,46,47]. Eight of the 12 surveys for which new data were requested/obtained [8,31,32,34-37,40] fulfilled criteria for inclusion of study results.…”

Section: Methodsmentioning

confidence: 99%

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Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

et al. 2013

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BackgroundA debate surrounding multiple sclerosis epidemiology has centred on time-related incidence increases and the need of monitoring. The purpose of this study is to reassess multiple sclerosis incidence in the European Economic Area.MethodsWe conducted a systematic review of literature from 1965 onwards and integrated elements of original research, including requested or completed data by surveys authors and specific analyses.ResultsThe review of 5323 documents yielded ten studies for age- and sex-specific analyses, and 21 studies for time-trend analysis of single data sets. After 1985, the incidence of multiple sclerosis ranged from 1.12 to 6.96 per 100,000 population, was higher in females, tripled with latitude, and doubled with study midpoint year. The north registered increasing trends from the 1960s and 1970s, with a historic drop in the Faroe Islands, and fairly stable data in the period 1980-2000; incidence rose in Italian and French populations in the period 1970-2000, in Evros (Greece) in the 1980s, and in the French West Indies in around 2000.ConclusionsWe conclude that the increase in multiple sclerosis incidence is only apparent, and that it is not specific to women. Monitoring of multiple sclerosis incidence might be appropriate for the European Economic Area.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

et al. 2013

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“…Regardless of the population used for standardization, more than twice as many females were newly diagnosed with MS in 2014 than males for a female to male ratio in PR of 2.3-2.4:1 depending on the standard population chosen. A comparable female to male ratio has been found in Canada (2.8:1), Iceland (3.0:1), and among Hispanics in California (2.1:1) [15,16,29]. Therefore, MS among females in PR could have different etiological, prognostic, and disease progression factors than males as reported in other parts of the world [28] while interacting with local environmental and genetic factors.…”

Section: Discussionmentioning

confidence: 88%

“…The only 2 available instances come from small islands with less than 700,000 people, which makes MS case ascertainment an infrequent event [5]. In contrast, the PR incidence rate is in the moderate range when compared to countries in Northern latitudes such as Canada (7.8/100,000) and Iceland (7.6/100,000) [15,16]. …”

Section: Discussionmentioning

confidence: 99%

Incidence of Multiple Sclerosis in Puerto Rico, 2014: A Population-Based Study

et al. 2017

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Background: Multiple sclerosis (MS) affects millions of people worldwide. The estimates for MS incidence are difficult to obtain but are important for understanding MS etiology, developing prevention strategies, and service planning. This study is aimed at estimating the 2014 incidence of MS in Puerto Rico (PR). Methods: The PR MS Foundation's registry was used as the data source. Neurologists, specialty pharmacies, MRI centers, health insurance companies, and the PR Department of Health identified MS cases missed by the registry. MS patients were 18 years and older and met the 2010 revised McDonald criteria. Age-standardized MS incidence rates and their corresponding 95% CIs were computed. Results: A total of 144 new MS cases were diagnosed in 2014. The age-standardized MS incidence rate was 5.1/100,000 (95% CI 4.3-5.9). The incidence rate was 7.1/100,000 (95% CI 5.7-8.5) for females and 2.9/100,000 (95% CI 2.0-3.8) for males. MS cases were mostly females (72.9%) with a mean age of 41.0 years (±1.0). Conclusion: According to the country estimates, PR has a higher MS incidence than other Caribbean and Latin American countries, but a lower incidence compared to countries at higher latitudes. Our findings provide insights into the MS etiology in the Hispanic population that require additional research.

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Multiple Sclerosis Epidemiology in Europe

Battaglia

2017

Advances in Experimental Medicine and Biology

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Multiple sclerosis is characterized by a non-homogeneous distribution around the world. Some authors in past described a latitude gradient, with increasing risk from the equator to North and South Poles, but this theory is still controversial. Regarding Europe, there are many articles in the literature concerning the epidemiology of this disease but, unfortunately, they are not always comparable due to different methodologies, they do not cover all countries in the continent, and most of them reported data of small areas and rarely at a national level. In 2012 there were 20 national registries that could help to describe the epidemiology of the disease and, in addition, there is an European Register for Multiple Sclerosis that collect data from already existing national or regional MS registries and databases. Another valid alternative to obtain epidemiological data, also at national level, in a routinely and cost-saving way is through administrative data that are of increasing interest in the last years.

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Incidence of multiple sclerosis in Iceland, 2002–2007: a population-based study

Abstract: A total population study is the most reliable method of determining the spectrum of clinical symptoms and the results of investigations in MS patients at diagnosis.

Cited by 14 publications

References 12 publications

Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

Incidence of Multiple Sclerosis in Puerto Rico, 2014: A Population-Based Study

Multiple Sclerosis Epidemiology in Europe

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