Incidence of myeloid neoplasms in Spain (2002–2013): a population-based study of the Spanish network of cancer registries

Solans, Marta; Sanvisens, Arantza; Ameijide, Alberto; Merino, Susana; Rojas, Dolores; Alemán, Araceli; Banqueri, Emilia; Chico, Matilde; Marcos, Ana Isabel Sánchez; Castro, Visitación de; Gil, Leire; Munain, Arantza López de; Puigdemont, Montse; Sánchez, María‐José; Perucha, Josefina; Ruiz-Armengol, Patricia; Chirlaque, M. D.; Guevara, Marcela; Carulla, Marià; Marcos‐Gragera, Rafael

doi:10.1038/s41598-021-03734-6

Cited by 12 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2011 projections also tabled on rises in kidney cancer rates in Spain 21 consistent with the mild exposure. An increasing incidence of myeloproliferative neoplasms and myelodysplastic syndroms is also found by Solans et al 22 for the period 2002 to 2013, in a way extremely consistent with muscle exposure to solar neutrons under « reverse magnet effect ». This mild exposure is also related with the mild intensity of the debt crisis in that country.…”

Section: Spainsupporting

confidence: 76%

The “Reverse Magnet Effect” of Alpha Emitters and the Health Costs of Depleted Uranium in the Balkans: The Root of the Debt Crisis in Greece, Italy, Portugal, Spain and Ireland

Pirot

2022

MRAJ

View full text Add to dashboard Cite

Very large scale health effects of the depleted uranium (DU) spreading from the Balkans can be observed through analysis of WHO DALYs data and explain the budgetary deficits at the roots of the 2010s’ debt crisis in Southern Europe (the “PIGS”, Portugal, Italy, Greece and Spain) and Ireland. The countries around the Balkans suffered from DU exposure through patterns of “positive push”, the brain being constrained in its decisions by pre-existing internal contamination with alpha emitters and their positive charge repelled by the new alpha emitters of the DU strikes in the Balkans (“reverse magnet effect” from +/+ repelling). The subjects are constrained to move in certain patterns by the positive resistance coming from the area of the Balkans, clogs emerge in their bodies leading for instance to cardiomyopathies, kidney and urinary diseases, mesothelioma and other neoplasms, along with immune deficiencies and mutations causing rises in infectious diseases, and alcoholism. The slow rise in alpha activity of depleted uranium, with its decay chain pattern leading to more and more alpha-emitting atoms over time (because daughter atoms are shorter-lived) causes a “timebomb” pattern (as usual in veterans of wars with DU) with an increasing “push” effect and explains the later public debt crisis. Beyond the so-called “PIGS”, Austria suffered as well a lot from the DU fallout, with health costs and environmental damage altogether and this is shown analytically. More direct endocrine effects on the brain are also shown, with behavioural consequences. The case for more epidemiological effects if nothing is done is clear and comes together with strong societal issues resulting directly from the intertwinning of the neurological impairments affecting decisionmaking and divergence in the answers that can be offered. NATO refunding of the ECB’s public bond-buying programs with depleted uranium to allow it to emit depleted uranium coins is suggested as final fixture to the root problems of the debt crisis.

show abstract

Section: Spainsupporting

confidence: 76%

The “Reverse Magnet Effect” of Alpha Emitters and the Health Costs of Depleted Uranium in the Balkans: The Root of the Debt Crisis in Greece, Italy, Portugal, Spain and Ireland

Pirot

2022

MRAJ

View full text Add to dashboard Cite

show abstract

“…The expected annual incidence rate of MPN is approximately 2 cases per 100,000 of the population [ 10 ]. Interestingly, newer studies report incidence rates of up to 5 cases per 100,000 [ 11 ]. Due to its chronic course, the prevalence rates of MPN are considerably higher.…”

Section: Introductionmentioning

confidence: 99%

Thromboinflammation in Myeloproliferative Neoplasms (MPN)—A Puzzle Still to Be Solved

Bhuria

Baldauf

Schraven

et al. 2022

IJMS

View full text Add to dashboard Cite

Myeloproliferative neoplasms (MPNs), a group of malignant hematological disorders, occur as a consequence of somatic mutations in the hematopoietic stem cell compartment and show excessive accumulation of mature myeloid cells in the blood. A major cause of morbidity and mortality in these patients is the marked prothrombotic state leading to venous and arterial thrombosis, including myocardial infarction (MI), deep vein thrombosis (DVT), and strokes. Additionally, many MPN patients suffer from inflammation-mediated constitutional symptoms, such as fever, night sweats, fatigue, and cachexia. The chronic inflammatory syndrome in MPNs is associated with the up-regulation of various inflammatory cytokines in patients and is involved in the formation of the so-called MPN thromboinflammation. JAK2-V617F, the most prevalent mutation in MPNs, has been shown to activate a number of integrins on mature myeloid cells, including granulocytes and erythrocytes, which increase adhesion and drive venous thrombosis in murine knock-in/out models. This review aims to shed light on the current understanding of thromboinflammation, involvement of neutrophils in the prothrombotic state, plausible molecular mechanisms triggering the process of thrombosis, and potential novel therapeutic targets for developing effective strategies to reduce the MPN disease burden.

show abstract

“…6 Among other myeloid neoplasms, myelodysplastic syndromes (MDSs) were so defined for the first time by the French-American-British Working Group in 1976 7 as a precursor stage for AML; only a few studies explored its epidemiological features. 1,8,9 A large multicentre Italian study of hematological malignancies did not observe a geographic pattern in the AML incidence among the participating areas. 10 However, no studies have evaluated the time trend of specific MYEL neoplasms in Italy thus far.…”

Section: Introductionmentioning

confidence: 94%

Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy

Broccia,

Carter,

Ozsin-Ozler

et al. 2023

Cancer Control

View full text Add to dashboard Cite

Background The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated. Methods We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors. Results The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding. Conclusions Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.

show abstract

Incidence of myeloid neoplasms in Spain (2002–2013): a population-based study of the Spanish network of cancer registries

Cited by 12 publications

References 41 publications

The “Reverse Magnet Effect” of Alpha Emitters and the Health Costs of Depleted Uranium in the Balkans: The Root of the Debt Crisis in Greece, Italy, Portugal, Spain and Ireland

The “Reverse Magnet Effect” of Alpha Emitters and the Health Costs of Depleted Uranium in the Balkans: The Root of the Debt Crisis in Greece, Italy, Portugal, Spain and Ireland

Thromboinflammation in Myeloproliferative Neoplasms (MPN)—A Puzzle Still to Be Solved

Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy

Contact Info

Product

Resources

About