Incidence of nasopharyngeal carcinoma in Chinese immigrants, compared with Chinese in China and South East Asia: review

Yu, Weijun; Hussain, S. S. M.

doi:10.1017/s0022215109005623

Cited by 74 publications

(45 citation statements)

References 34 publications

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“…NPC occurs particularly frequent in China and Southeast Asia, with an annual incidence rate of about >20 per 100,000 in endemic areas (Yu et al, 2002;Bray et al, 2005;Chang et al, 2006). Descendants of Chinese who emigrated to Western countries have lower NPC incident rates than do Chinese in Asia, but their rates remain higher than those of White populations in Western countries (Buell et al, 1974;Yu et al, 2009). Globally, NPC accounts for about 80,000 new cases and 50,000 deaths annually (Bray et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Trends in Nasopharyngeal Carcinoma Mortality in China, 1973-2005

Huang¹,

Si-wei²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The trend was similar in both men and women, in both urban and rural areas, but the declining rates in females were more remarkable than in males. The mortality rates were higher for the age groups above 50 years than those less than 50 years of age, both showing downward trend over 30-year period. In summary, the overall NPC mortality has consistently decreased in China over the past three decades, particularly in women and in old adults.

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Section: Introductionmentioning

confidence: 99%

Trends in Nasopharyngeal Carcinoma Mortality in China, 1973-2005

Huang¹,

Si-wei²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…1,2 In NPC epidemic regions, the incidence rate is about 20-30/100,000 general population. The etiological factors associated with the geographic and ethnic pattern of NPC remain unclear.…”

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confidence: 99%

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Zhang

Zong

Shen

et al. 2014

Intl Journal of Cancer

104

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More than 75% of nasopharyngeal carcinoma (NPC) patients have already developed local or regional spread at diagnosis, which hampers effective treatment and results in a poor prognosis. It is essential to characterize more sensitive and specific biomarkers for screening of high risk individuals and assessment of NPC treatment effectiveness. NPC is an Epstein-Barr virus (EBV) associated tumor in which only a few viral proteins but more than 20 BamHI A rightward transcripts (BART) microRNAs are detected, at abundant levels. We hypothesized that these BART microRNAs may be novel biomarkers for NPC. Systematic analysis of EBV BART microRNA expression profiles in EBV latently infected Mutu I and Mutu III cell lines, EBV-harboring NPC and noncancerous NP cells found that miR-BART3, miR-BART7 and miR-BART13 microRNAs are highly expressed and regularly secreted into the extracellular environment of NPC cells. These BART microRNAs were evaluated for used as potential NPC biomarkers. Analysis of plasma specimens obtained from NPC patients (n 5 89), and healthy (n 5 28) and non-NPC tumor patient controls (n 5 18) found levels of both miR-BART7 and miR-BART13, but not miR-BART3, to be distinctly presence among NPC patients, with elevated levels being particularly apparent among patients with advanced disease. Receiver operating characteristic curve analysis combining miR-BART7 and miR-BART13 levels produces a 90% predictive value for the presence of NPC. Analysis of 41 NPC patients before and after radiotherapy showed that miR-BART7 and miR-BART13, but not miR-BART3, were diminished after treatment. These results indicate that EBV microRNAs, miR-BART7 and miR-BART13, may constitute useful new serological biomarkers for diagnosis of NPC and prediction of treatment efficacy.

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“…Environmental factors are important as migrant studies have shown that the rates decline to intermediate rates between the countries of origin and countries of residence. (Yu and Hussain 2009;Mousavi et al, 2010). Low economic social status, an indirect indicator to exposures of the risk factors has also been reported to be associated with NPC.…”

Section: Discussionmentioning

confidence: 99%

Declining Incidence of Nasopharyngeal Carcinoma in Brunei Darussalam: a Three Decade Study (1986-2014)

Chong¹,

Telisinghe²,

Lim³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Incidence of nasopharyngeal carcinoma in Chinese immigrants, compared with Chinese in China and South East Asia: review

Abstract: This review found a decreasing trend in the incidence of nasopharyngeal carcinoma in Chinese migrants living in countries with a low risk of the disease.

Cited by 74 publications

References 34 publications

Trends in Nasopharyngeal Carcinoma Mortality in China, 1973-2005

Trends in Nasopharyngeal Carcinoma Mortality in China, 1973-2005

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Declining Incidence of Nasopharyngeal Carcinoma in Brunei Darussalam: a Three Decade Study (1986-2014)

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