Incidence of neonatal hyperviscosity at sea level

Stevens, Kathleen; Writh, Frederick H.

doi:10.1016/s0022-3476(80)80149-1

Cited by 44 publications

(17 citation statements)

References 9 publications

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“…The incidence of polycythemia is 1.5%-4% of all live births [4,5]. The incidence is higher among both small for gestational age (SGA) and large for gestational age (LGA) infants.…”

Section: Incidencementioning

confidence: 99%

Management of Polycythemia in Neonates

et al. 2010

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Polycythemia is defined as a venous hematocrit above 65%. The hematocrit in a newborn peaks at 2 h of age and decreases gradually after that. The relationship between hematocrit and viscosity is almost linear till 65% and exponential thereafter. Increased viscosity of blood is associated with symptoms of hypo-perfusion. Clinical features related to hyperviscosity may affect all organ systems. Neonates born small for gestational age (SGA), infants of diabetic mothers (IDM), and multiple births are at risk for polycythemia. They should therefore undergo screening at 2, 12, and 24 h of age. Polycythemia may be symptomatic or asymptomatic and guidelines for the management of both types based on the current evidence are provided in the protocol.

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“…The incidence of polycythemia is 1.5%-4% of all live births [4,5]. The incidence is higher among both small for gestational age (SGA) and large for gestational age (LGA) infants.…”

Section: Incidencementioning

confidence: 99%

Management of Polycythemia in Neonates

et al. 2010

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“…Neonatal polycythemia, defined as a central venous hematocrit greater than 65% (I), is diagnosed in 0.5 to 2.9% of all births at sea level (2,3). It can be attributed to excessive placental transfusion at birth, or to increased production of red blood cells, resulting in an elevated concentration of circulating erythropoietin (4).…”

Section: Kurlat Division Of Neonatology Hospital De Pediatria "Jmentioning

confidence: 99%

Neonatal polycythemia in appropriately grown infants of hypertensive mothers

Kurlat

Sola

1992

Acta Paediatrica

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Neonatal polycythemia is a frequent finding after pregnancies complicated by diabetes and by maternal hypertension with intrauterine growth retardation (IUGR). It is still unclear if the association of polycythemia with hypertension is the result of IUGR or of hypertension per se. To establish the incidence of neonatal polycythemia in populations at risk, we analyzed the results of hematocrit values obtained from 1592 neonates born consecutively at the Hospital de Clinicas, Buenos Aires. Capillary hematocrit values were obtained by heel stick before 6 h of age. When the values were 65% or greater, new samples were obtained from an antecubital vein. The risk of polycythemia in appropriately grown infants of hypertensive mothers was 12.6-fold greater than the risk in the general population. These data show that maternal hypertension poses a significant risk for polycythemia, regardless of fetal growth. We suggest that, to prevent possible sequela, hematocrit is measured routinely in all infants of hypertensive mothers for prompt diagnosis and treatment.

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“…In previous reports, neonatal polycy themia ranges from 1.5 to 20% [4,15,[18][19][20], Wide variability appears to result from varia tions in sampling sites [3,21], umbilical clamping times [17], sampling times [4,5], and definitions of neonatal polycythemia.…”

Section: Discussionmentioning

confidence: 99%

Polycythemia of the Preterm and Full-Term Newborn Infant: Relationship between Hematocrit and Gestational Age, Total Blood Solutes, Reticulocyte Count, and Blood pH

Carmi

Wolach²,

Dolfin³

et al. 1992

Neonatology

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The umbilical venous hematocrit at birth (Hct 1) and the peripheral venous hematocrit at 2 h of life (Hct 2) were determined in 78 healthy full-term and 14 healthy preterm newborn infants. Hct 1 was 51.6 ± 4.1 % in full-term infants and 50.8 ± 4% in preterm infants. Hct 2 was 60.9 ± 2 and 58.6 ± 6.1% in full-term and preterm infants, respectively. Significant differences between Hct 1 and Hct 2 were found in both groups of infants (p < 0.01). The blood viscosity increased significantly in both groups from birth to 2 h of life. Neonatal polycythemia (Hct higher than 70% at 2 h of life) was detected in only 3 full-term infants (3.8%). They received partial exchange transfusion. There was a positive linear correlation of Hct 1 with Hct 2 in full-term newborns (r = 0.71 p < 0.001) and preterm infants (r = 0.57, p < 0.02). No infants with Hct 1 equal to or below 50% had Hct 2 higher than 65%. None with Hct 1 between 51 and 54% had Hct 2 higher than 70%. Neither Hct 1 nor Hct 2 correlated with birth weight, gestational age, total blood solutes, or reticulocyte counts at birth in either group. An inverse linear correlation was found between blood pH at birth and Hct 2 in preterm newborn infants (r = 0.66, p < 0.02).

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Incidence of neonatal hyperviscosity at sea level

Cited by 44 publications

References 9 publications

Management of Polycythemia in Neonates

Management of Polycythemia in Neonates

Neonatal polycythemia in appropriately grown infants of hypertensive mothers

Polycythemia of the Preterm and Full-Term Newborn Infant: Relationship between Hematocrit and Gestational Age, Total Blood Solutes, Reticulocyte Count, and Blood pH

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