Incidence of Neonatal Infection in South Sinai, Egypt

Medhat, Hisham; Khashana, Abdelmoneim; Kalioby, Mohamed El

doi:10.17795/iji-36615

Cited by 30 publications

(50 citation statements)

References 15 publications

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“…This study revealed that pooled prevalence of neonatal sepsis in Ethiopia is consistent with the findings from Cameroon (37.9%) [35], Tanzania (38.9%) [36], and Egypt (45%) [37]. However, our finding is higher than previous studies reported in Iran (18.4%) [38], Mexico (4.3%) [39], and Egypt (8.6%) [40]. This variation could be due to unique cultural features of the population, local obstetrics and neonatal practices, socioeconomic and sexual practice, hygiene, and nutritional differences over settings [41] as well as due to clinical features for sepsis identification, study methodology, and sample size difference which we observed during our study.…”

Section: Discussionsupporting

confidence: 90%

Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

Assemie

Alene

Yismaw

et al. 2020

International Journal of Pediatrics

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Introduction. Neonatal sepsis is a systemic infection occurring in infants during the first 4 weeks of life and is a major cause of mortality and morbidities of newborns due to their age-related weak and immature immune systems. In Ethiopia, despite many studies being conducted on neonatal sepsis, the reported findings are inconsistent. The aim of this study is to determine the prevalence of neonatal sepsis to enhance the utility and interpretation of the evidence. Methods. An extensive systematic review and meta-analysis were performed to extract studies on the prevalence of neonatal sepsis in Ethiopia. The PubMed, Cochrane Library, ScienceDirect, Web of Science, and Google Scholar were systematically searched. Two independent authors selected and extracted the data from each included article. The heterogeneity of included studies was assessed using the Higgins I2 test, and a random-effects model was performed in Stata/se Version 14. Results. Eighteen studies with a sample size of 10,495 study subjects were included with a reported range of neonatal sepsis from 17% to 78%. The pooled prevalence of neonatal sepsis was 45% (95% CI: 35, 55; I2=99.3%, p<0.01). Early onset neonatal sepsis was found to have a prevalence of 75.4% (95% CI: 68.3, 82.6). Subgroup analysis in the study area (i.e., by region) was calculated revealing the highest neonatal sepsis in Amhara region at 64.4% (95% CI: 44.9, 84.0) and the lowest in Southern Nations, Nationality, and People at 28% (95% CI: 16, 40). Conclusion. In this review, the prevalence of neonatal sepsis in Ethiopia was found to be high, especially in terms of early onset neonatal sepsis. As a result of the findings, it is important to consider the early and optimal points for interventions to better manage the prevalence and outcomes of neonatal sepsis. Further research is needed to investigate the neonatal sepsis status at different regions and associated factors for neonatal sepsis not yet studied.

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Section: Discussionsupporting

confidence: 90%

Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

Assemie

Alene

Yismaw

et al. 2020

International Journal of Pediatrics

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“…Those neonates whose age ranged from 0 to 7 days were two times more likely to develop sepsis as compared to those whose age ranged from 8 to 28 days (adjusted OR=2.19, 95% CI: 1.01-4.79) ( Table 4). [15][16][17][18][19] But, this finding was congruent with three studies done at Tanzania (29%, 31.4%, and [20][21][22] The reason for this difference is due to advance in health system nowadays that gives infuses on newborn health start from intrauterine life (training of healthcare providers on infection prevention in delivery ward and NICU, safe delivery practice, basic emergency obstetric care, and comprehensive emergency obstetric care), increasing the health seeking behavior, and socioeconomic status of the community. In this study, maternal-related factors were significantly associated with neonatal sepsis.…”

Section: Factors Associated With Neonatal Sepsismentioning

confidence: 99%

“…This finding was incongruent with study done in Ghana, Egypt, south-eastern Mexico, Northern Ethiopia, and Mwanza Tanzani. 17,18,22,25,26,31 The result of these incongruences may be due to the fact that the newborns are more susceptible for hospital as well as community-acquired infections in favor of maternal and neonatal factors. In addition, those discrepancies may be study setting, sociocultural, socioeconomic, and study period differences.…”

Section: Factors Associated With Neonatal Sepsismentioning

confidence: 99%

“…12 Evidence from different studies conducted in different countries speculated that neonates who were diagnosed with suspected sepsis ranged from 4.3% to 75.1% among the neonates admitted to the neonatal intensive care units (NICUs). [15][16][17][18][19][20][21][22] Despite advancing healthcare system in Ethiopia, the admission of neonates to the NICU with infection, most typically sepsis, has been increased. But, there is limited study in Ethiopia, in study area that shows the recent status of neonatal sepsis and the affecting factors.…”

Section: Introductionmentioning

confidence: 99%

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<p>Neonatal sepsis and associated factors among newborns in hospitals of Wolaita Sodo Town, Southern Ethiopia</p>

Mersha¹,

Worku²,

Shibiru³

et al. 2019

RRN

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“…Sepsis is still one of the responsible etiologies of neonatal morbidity and mortality all over the world in-spite of technological developments in neonatal health care units [3] . In Egypt, the incidence of neonatal sepsis in South Sinai Governorate hospitals was 8.6% in the NICUs and mortality rate among septic neonates (sepsis fatality rate) was about 25% [4] . The discovery of vitamin D receptors (VDR) in different immune cells (e.g., B cells, neutrophils, T cells, macrophages and dendritic cells) was associated with elucidation of the important role of vitamin D in the human health.…”

Section: Introductionmentioning

confidence: 99%

Impact of serum level of vitamin D on term neonates with early onset sepsis

Soliman

Sakr

Emran

et al. 2019

International Journal of Medical Arts

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Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates. Methodology: This is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis. Results: vitamin D level showed significant negative correlation with sepsis, Creactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis. Conclusions: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.

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Incidence of Neonatal Infection in South Sinai, Egypt

Cited by 30 publications

References 15 publications

Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

<p>Neonatal sepsis and associated factors among newborns in hospitals of Wolaita Sodo Town, Southern Ethiopia</p>

Impact of serum level of vitamin D on term neonates with early onset sepsis

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