Incidence of Non–Small-Cell Lung Cancer among California Hispanics According to Neighborhood Socioeconomic Status

Wong, Melisa L.; Clarke, Christina A.; Yang, Juan; Hwang, Jimmy J.; Hiatt, Robert A.; Wang, Sunny

doi:10.1097/jto.0b013e31827bd7f5

Cited by 18 publications

(16 citation statements)

References 31 publications

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“…Furthermore, we found some indications of a negative association with deprivation, with a decreased risk in the most deprived areas, more evident among women. Similar results were also found in populations at the earlier stages of the smoking epidemic [33,34]. Social inequalities in respiratory cancer incidence are largely explained by the social distribution of smoking habits.…”

Section: Discussionsupporting

confidence: 80%

Disparities in cancer incidence by area-level socioeconomic status in the French West Indies

Luce

Michel

Dugas

et al. 2017

Cancer Causes Control

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Section: Discussionsupporting

confidence: 80%

Disparities in cancer incidence by area-level socioeconomic status in the French West Indies

Luce

Michel

Dugas

et al. 2017

Cancer Causes Control

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“…We found that patients with higher education degree incurred a moderate decrease at the advanced stage at diagnosis. In fact, many studies revealed a similar association between education/income and cancer outcome and the impact varied by race/ethnic, smoking, insurance style, and cancer screening program [19,[26][27][28][29][30]. Moreover, the two studies suggested that more deprived patients were likely to present with more advanced-stage cancer in non-UHCS in the USA.…”

Section: Discussionmentioning

confidence: 99%

“…The socioeconomic measurements have proved useful to monitor health inequalities and can provide fundamental implications for prevention initiatives and resource allocation [16][17][18]. To date, the role of SES, either at individual or area level, in shaping lung cancer risk has only been examined from outside of China [9,12,[19][20][21]. Since each study has used different variables and different approaches to estimate individual or neighborhood socioeconomic conditions, the accumulated evidence is difficult to assess systematically in China.…”

Section: Introductionmentioning

confidence: 99%

Effect of socioeconomic status on stage at diagnosis of lung cancer in a hospital‐based multicenter retrospective clinical epidemiological study in China, 2005–2014

Shi

et al. 2017

Cancer Medicine

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There is inconsistent evidence of associations between socioeconomic status (SES) and lung cancer stage in non‐Chinese populations up to now. We set out to determine how SES affects stage at diagnosis at both individual and area levels, from a hospital‐based multicenter 10‐year (2005–2014) retrospective clinical epidemiological study of 7184 primary lung cancer patients in mainland China. Individual‐level SES data were measured based on two indicators from case report forms of the study: an individual's education and occupation. Seven census indicator variables were used as surrogates for the area‐level SES with principal component analysis (PCA). Multivariate analysis was undertaken using binary logistic regressions and multinomial logit model to describe the association and explore the effect across tertiles on stage after adjusting for demographic variables. There was a significant stepwise gradient of effect across different stages in the highest tertile of area‐level SES, comparing with the lowest tertile of area‐level SES (ORs, 0.77, 0.67, and 0.29 for stage II, III, and IV). Patients with higher education were less likely to have stage IV lung cancer, comparing with the illiterate group (ORs, 0.52, 0.63, 0.71, 0.64 for primary school, middle school, high school, college degree or above subgroup, respectively). Findings suggest that the most socioeconomically deprived areas may be associated with a higher risk of advanced‐stage lung cancer, and increasing educational level may be correlated with a lower risk to be diagnosed at advanced stage in both men and women.

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“…Other studies have investigated ethnic differences in polymorphisms in genes involved in carcinogen metabolism such as CYP1A1 (14), CYP1B1 (15), and GSTM1 (16), and in DNA repair (17) and DNA damage signaling (18), with respect to lung cancer incidence. Socioeconomic aspects of the observed ethnic differences have also been investigated (19-21). A clear explanation for the observations cited above in the MEC has not yet emerged from these studies although it is recognized that some of these factors likely contribute.…”

Section: Introductionmentioning

confidence: 99%

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

Park

Carmella

Ming

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Results of the Multiethnic Cohort study (MEC) demonstrated that, for the same quantity of cigarettes smoked, African Americans (AfrAm) and Native Hawaiians (NH) have a higher risk of lung cancer compared to Whites, whereas Latinos (LA) and Japanese Americans (JA) have a lower risk. We hypothesize that the uptake and/or metabolism of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) could explain the differences in lung cancer risk. Methods We measured urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides and their sum (total NNAL), biomarkers of NNK uptake, in 2,252 smokers from the MEC. Ethnic-specific geometric means were compared adjusting for age at urine collection, sex, creatinine and total nicotine equivalents, a marker of total nicotine uptake. Results AfrAm had the highest median total NNAL levels (1.80 pmol/ml urine) and JA the lowest (0.914 pmol/ml urine), with intermediate values in the other three groups. Geometric mean of total NNAL in AfrAm was also highest and in JA was lowest; JA geometric mean was statistically different from Whites (P=0.004). Conclusions AfrAm had higher levels of total NNAL per ml urine than Whites while JA had lower levels, consistent with lung cancer risk among smokers in these groups. However, our data were not consistent with the high and low lung cancer risks of NH and LA smokers, respectively. Impact The higher lung cancer susceptibility of AfrAm smokers and the lower susceptibility of JA smokers compared to Whites can be explained in part by exposure to the potent lung carcinogen NNK.

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Incidence of Non–Small-Cell Lung Cancer among California Hispanics According to Neighborhood Socioeconomic Status

Cited by 18 publications

References 31 publications

Disparities in cancer incidence by area-level socioeconomic status in the French West Indies

Disparities in cancer incidence by area-level socioeconomic status in the French West Indies

Effect of socioeconomic status on stage at diagnosis of lung cancer in a hospital‐based multicenter retrospective clinical epidemiological study in China, 2005–2014

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

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