Incidence of nonalcoholic fatty liver disease in patients undergoing laparoscopic cholecystectomy

Hajong, Ranendra; Dhal, Malaya Ranjan; Naku, Narang; Kapa, Buru

doi:10.4103/jfmpc.jfmpc_193_18

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Conventional imaging techniques [Ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI)] have low to moderate accuracy to identify liver fibrosis (Allan et al 2010 ; Lo et al 2017 ). Sonography and unenhanced CT effectively detect steatosis if fatty infiltration is > 10% and > 30%; respectively (Obika and Noguchi 2012 ; Ballestri et al 2017 ; Hajong et al 2018 ). Fluorodeoxyglucose positron emission tomography/CT (FDG-PET/CT) plays a specific role in assessing diagnosis, staging, and monitoring therapeutic response in oncology imaging (Luk et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Ali,

El-Abd,

Morsi

et al. 2023

European J Hybrid Imaging

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Background Hepatic steatosis is the most common chronic hepatic disease. Imaging diagnosis of hepatic steatosis has been evaluated as an alternative to invasive histological diagnosis. Study aims The study aimed to assess the effect of hepatic steatosis on Flourine-18 fluorodeoxyglucose (18F-FDG) uptakes in cancer patients. Patients and Methods Blood samples were collected from 50 cancer patients and analyzed to calculate fatty liver index and Hepatic steatosis index (HIS). Hepatic steatosis examined using high-resolution ultrasound and positron emission tomography—computed tomography (PET-CT). Linear attenuation coefficient, standardized-uptake value (SUV) mean (SUV mean), and SUV maximum (SUVmax) were measured. Accordingly, patients were divided equally into non-fatty liver, and fatty liver groups. Results A significant increase in SUVmax and SUV mean was observed in the fatty liver group more than in the non-fatty liver group. HSI significantly increased in the fatty liver group compared to the non-fatty liver group. Liver tissue uptake FDG was significantly correlated with HSI values. SUV max significantly correlated with body mass index (BMI) in the non-fatty group only. Conclusion Hepatic changes in cancer patients affect the liver metabolic activity and thus the 18 F-FDG uptake. Therefore, further corrections should be considered when the liver is used as a comparator for PET-CT scans of cancer patients.

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Section: Introductionmentioning

confidence: 99%

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Ali,

El-Abd,

Morsi

et al. 2023

European J Hybrid Imaging

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“…In view of the tight relationship between GSD and metabolic derangements, many studies were performed with topics on associations between GSD and MetS/NAFLD occurrence (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Otherwise, the impacts of cholecystectomy on postoperative NAFLD were also assessed in previous studies (12,31,(37)(38)(39)(40)(41). However, the above relationships were still controversial with difference across individual studies.…”

Section: Introductionmentioning

confidence: 99%

Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease

et al. 2022

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BackgroundPatients with gallstone disease (GSD) often have highly co-occurrence with metabolic syndrome (MetS) and Nonalcoholic fatty liver disease (NAFLD) both associated with insulin resistance (IR). Meanwhile, highly prevalence of NAFLD was found in patients who received cholecystectomy. However, the associations of GSD with MetS, NAFLD is inconsistent in the published literature. And risk of cholecystectomy on NAFLD is unclear.MethodsWe searched the Medline EMBASE and WOS databases for literature that met our study topic. To be specific, studies with focus on associations between GSD and MetS/NAFLD, and risk evaluation on cholecystectomy and NAFLD incidence were enrolled for further analysis. The random effect model was used to calculate the combined relative ratio (RR) and odds ratio (OR)and 95% confidence interval (CI).ResultsSeven and six papers with focus on connections between GSD and NAFLD/MetS prevalence. Correspondingly, seven papers with focus on risk of cholecystectomy on NAFLD occurrence were also enrolled into meta-analysis. After pooling the results from individual study, patients with GSD had higher risk of MetS (OR:1.45, 95%CI: 1.23-1.67, I2 = 41.1%, P=0.165). Risk of GSD was increased by 52% in NAFLD patients (pooled OR:1.52, 95%CI:1.24-1.80). And about 32% of increment on NAFLD prevalence was observed in patients with GSD (pooled OR: 1.32, 95%CI:1.14-1.50). With regard to individual MetS components, patients with higher systolic blood pressure were more prone to develop GSD, with combined SMD of 0.29 (96%CI: 0.24-0.34, P<0.05). Dose-response analysis found the GSD incidence was significantly associated with increased body mass index (BMI) (pooled OR: 1.02, 95%CI:1.01-1.03) in linear trends. Patients who received cholecystectomy had a higher risk of post-operative NAFLD (OR:2.14, 95%CI: 1.43-2.85), P<0.05). And this impact was amplified in obese patients (OR: 2.51, 95%CI: 1.95-3.06, P<0.05).ConclusionOur results confirmed that controls on weight and blood pressure might be candidate therapeutic strategy for GSD prevention. And concerns should be raised on de-novo NAFLD after cholecystectomy.

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“…5,9,10 In this study, we aim to determine the frequency of Gallstones as well as NAFLD in our patients and to see if these two diseases are related. 11 This information will help us in better understanding of relationship between these diseases and thus will lead to improved management and improved patient outcomes. We compared our results with other published literature to see whether there is an effect of ethnicity and geography on the frequency of these disease.…”

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confidence: 99%

Frequency of Gallstones in Fatty Liver disease in a Tertiary Care of Suburban Islamabad

Idbaïh¹,

Zahid²,

Mustafa³

et al. 2023

J Islamabad Med Dental Coll

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Background: Gallstone disease and Non-Alcoholic Fatty Liver Disease (NAFLD) share common etiological pathways. The objective of this study was to determine the frequency of Gallstones and Non-Alcoholic Fatty Liver disease (NAFLD) in patients undergoing abdominal ultrasounds in our hospital and to compare the frequency of Gallstone disease in patients with NAFLD and without NAFLD. Methodology: This cross-sectional study was carried out at HBS General Hospital, Islamabad from January 2020 till December 2020. Patients undergoing routine ultrasounds in the out-patient department of the hospital were included in the study. Patients having Emergency Ultrasounds, history of Alcohol intake, history of chronic liver disease and pregnant patients were excluded from the study. Data was analysed using Microsoft Excel 2016 and IBM SPSS 22. Results: A total of 689 patients were included with a 3:1 Female to Male ratio. Mean Age was 40.65± 15.610 years. The prevalence of Gallstone disease was found to be 20.9% while that of NAFLD 27.6%. A higher percentage of patients with NAFLD had Gallstones as compared to those who did not have NAFLD (24.2% vs 19.6% respectively) however for overall data, statistical significance was not reached. A statistically significant greater number of young patients with NAFLD had Gallstones as compared to those who did not have NAFLD (50% vs 6%, p<0.001). Mean age was greater in patients who had NAFLD as well as those having Gallstones. Conclusion: The frequency of Gallstones was greater in patients with NAFLD as compared to those without NAFLD. Keywords: Cholelithiasis, Fatty Liver Disease, Gallstones, Non-Alcoholic, Ultrasonogram

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Incidence of nonalcoholic fatty liver disease in patients undergoing laparoscopic cholecystectomy

Cited by 5 publications

References 24 publications

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease

Frequency of Gallstones in Fatty Liver disease in a Tertiary Care of Suburban Islamabad

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