Incidence of noncutaneous melanomas in the U.S.

Abstract

BACKGROUNDDescription of the epidemiology of noncutaneous melanoma has been hampered by its rarity. The current report was the largest in‐depth descriptive analysis of incidence of noncutaneous melanoma in the United States, using data from the North American Association of Central Cancer Registries.METHODSPooled data from 27 states and one metropolitan area were used to examine the incidence of noncutaneous melanoma by anatomic subsite, gender, age, race, and geography (northern/southern and coastal/noncoastal) for cases diagnosed between 1996 and 2000. Percent distribution by stage of disease at diagnosis and histology were also examined.RESULTSBetween 1996 and 2000, 6691 cases of noncutaneous melanoma (4885 ocular and 1806 mucosal) were diagnosed among 851 million person‐years at risk. Ocular melanoma was more common among men compared with women (6.8 cases per million men compared with 5.3 cases per million women, age‐adjusted to the 2000 U.S. population standard), whereas mucosal melanoma was more common among women (2.8 cases per million women compared with 1.5 cases per million men). Rates of ocular melanoma among whites were greater than eight times higher than among blacks. Rates of mucosal melanoma were approximately two times higher among whites compared with blacks.CONCLUSIONSIn contrast to cutaneous melanoma, there was no apparent pattern of increased noncutaneous melanoma among residents of southern or coastal states, with the exception of melanoma of the ciliary body and iris. Despite their shared cellular origins, both ocular and mucosal melanomas differ from cutaneous melanoma in terms of incidence by gender, race, and geographic area. Cancer 2005. © 2005 American Cancer Society.

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

“…In the review article by Hicks and Flaitz, aggregated data are given from several articles related to melanomas of the mucosa of the head and neck, which include 703 cases of oral mucosa and 770 cases of sinonasal mucosa (Table 2) 4,26,27 . In the review article by Mihajlović et al 36 , data are cited from the American literature that OM are rare tumors with an annual incidence of 0.2 per million, that is, 1 case per 5 million people 37 . Th e authors from South America provide a fi gure of 1.2 OM cases per 10 million 38 .…”

Responses to immune checkpoint inhibitors in nonagenarians

“…All three patients were Caucasian females, which may reflect the demographics of patients over age 90 (female preponderance) and those at risk for melanoma (predominately Caucasian compared with other racial and ethnic groups). 35 Although having a chronological age in the 90s, their functional status was relatively preserved with complete independence in self-care and other activities of daily living. Two patients had classical, RECIST-defined responses to therapy, and the other had prolonged stable disease.…”

Primary Malignant Melanoma of the Cervix, A Case Report and Brief Review of Literature

“…10 Genelde postmenopozal hastalarda daha sık gözlenmekle birlikte daha erken yaşlarda da gözlenebilmektedir. 4,11 Servikal MM tanısı, jinekolojik muayene, histopatolojik inceleme, elektron mikroskobisi ve immünohistokimyasal boyalar ile konmaktadır. İns-peksiyonda şüpheli lezyonlar eksizyonel biyopsi ile immün histopatolojik incelemeye gönderilmekte-dir.…”