Incidence of nonmelanoma skin cancer in a cohort of patients with vitiligo

Abstract

Background Nonmelanoma skin cancer (NMSC) incidence in patients with vitiligo has not been studied. Objective We sought to quantify the incidence of NMSC in patients with vitiligo. Methods A cohort of 477 patients with vitiligo and no history of NMSC seen in an outpatient academic center between January 2001 and December 2006 was established. All charts for patients with vitiligo were reviewed for incident NMSC, and histopathology verified. Age-adjusted (2000 US Standard Million) incidence rates were calculated and compared to US rates. Results Six patients with NMSC were identified; all were Caucasian (>61 years).‘Age-adjusted incidence rates were: basal cell carcinoma, male 1382/100,000; basal cell carcinoma, female 0; squamous cell carcinoma, male 465/100,000; squamous cell carcinoma, female 156/100,000. Except for basal cell carcinoma in females, all rates were higher than US rates but not statistically significant. Limitations Comparison incidence rates from the general patient population during the same time period were unavailable. Conclusion Health care providers should be aware of the possible risk of NMSC in Caucasian patients with vitiligo.

Long-term prognosis of vitiligo patients on narrowband UVB phototherapy

“…2 Only 2 of the 6 NMSCs identified were on vitiliginous skin, which supports existing evidence that NMSC in vitiliginous lesions is rare. 3 Furthermore, vitiliginous skin is observed to be less susceptible to photodamage.…”

Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis

“…The total number of expected NMSC cases was calculated as a summation of all individual accumulated expected incidence rates over the years of observation [12]. Because incidence rates of NMSC in the general population are not captured in US Surveillance Epidemiology and End Results (SEER) database or in any national cancer registries [13], we assumed expected incidence rate to be the same as the age-and sex-matched incidence rate reported in a comparable population in New Hampshire during 1993-1994 [14]. The cohort was comparable to ours in term of latitude, age and access to healthcare.…”

Solar cheilosis: An ominous precursor

“…78 There is conflicting evidence regarding the impact of vitiligo on the risk of NMSC. 79,80 A causative relationship between smoking tobacco and the development of SC or lip SCC has not been established. It plays a much lesser contributory role in lip cancer when compared to sun exposure.…”