Incidence of Nonresponsiveness to Epinephrine in Platelets from Healthy Humans

Choi, Jong Weon

doi:10.1159/000064750

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…The decrease in intracellular cAMP level during platelet aggregation is similar in those showing a response to Epi and those that do not (Nakahashi et al. , 2001; Choi, 2002). An impaired response to Epi may therefore be related to the pathway following cAMP, or a disturbance in the β γ subunits of the receptor or a problem in a Gi α z activation pathway other than AC.…”

Section: Discussionsupporting

confidence: 57%

Evaluation of platelet function and lack of response to epinephrine in pregnant women

Sağdilek

Büyükcoşkun

Ozluk

2006

Int J Lab Hematology

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Summary Previous studies in healthy subjects have demonstrated a lack of response of platelets to epinephrine at a rate of 16–40% on an aggregometer. An association between the increased procoagulant factors during pregnancy and venous thromboembolism is known, and it has also been shown that prolactin levels increase platelet aggregation. We evaluated whether platelet functions in pregnant women and also assessed the lack of response to epinephrine during this period. We compared 27 healthy and volunteering pregnant women with 26 similar control subjects. Platelet functions were assessed with an aggregometer and a Platelet Function Analyzer (PFA‐100). Less than 40% response to epinephrine on the aggregometer was defined as an impaired epinephrine response. The aggregation response of epinephrine was normal in 25 of the 27 pregnant women, while two of them showed a late‐rising response. Eight of the 26 subject control group (30.8%) showed an impaired response to epinephrine. When we compared the 25 pregnant and 18 control subjects with normal aggregation responses, the maximum aggregation responses to ADP and epinephrine, and the Col/Epi and Col/ADP cartridge closure time values were significantly lower in pregnant women. There were no difference beetween second and third trimesters as regards platelet function parameters. The fact that no impaired response to epinephrine was detected in pregnant women while a 30% rate was observed in non‐pregnant women indicates that the platelet malfunction caused by a disorder in the Gi protein and intracellular mechanisms is bypassed during pregnancy thanks to some physiological changes.

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Section: Discussionsupporting

confidence: 57%

Evaluation of platelet function and lack of response to epinephrine in pregnant women

Sağdilek

Büyükcoşkun

Ozluk

2006

Int J Lab Hematology

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“…Epinephrine is an adrenergic agonist, bind with alpha 2-adrenergic receptors on platelets and also increases the effect of aggregation caused by other platelet agonists (Porth, 2005;Strukova, 2001). The capability of epinephrine induces the effect of aggregating agents on accumulation like fibrinogen binding, intracellular Ca2+ recruitment, granular relief and protein phosphorylation, and there are some factors correlate with platelet hyper-activity and resulting untimely coagulation of blood (Choi, 2002;Lanza et al, 1988). Similarly, collagen is the most thrombogenic component of the sub-endothelium (Baumgartner and Haudenschild, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…Camomile, bramble are similarly powerful at repressing platelet accumulation in-vitro (Pierre et al, 2005). Toona microcarpa Harms leaf (TMHE) extract in-vitro significantly inhibited platelet aggregation induced by thrombin, but not by ADP or collagen (Choi, 2002). Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats (Mekhfi et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

A preliminary investigation of in vitro anti-thrombotic and anti-platelet activity of Pinus Gerardiana

et al. 2017

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Introduction: Hemostasis is a process which preserves the stability of a closed and highpressure circulatory system after any vascular injury. Circulating platelets are recruited to the site of injury, where they develop a major component of the developing thrombus, blood clotting, started by tissue factor, concludes in the generation of thrombin and fibrin. Thrombosis is a serious event in the arterial diseases and a major cause in the development of myocardial infarction, stroke and venous thrombo-embolism which justify prominent morbidity and mortality rate. The knowledge of molecular and cellular mechanism of the formation of thrombus has developed considerably in the recent studies by using different in-vitro and in-vivo models of diseases. P. gerardiana nut oil has been reported to possess anti-bacterial, anti-fungal, anti-viral, anti-septic, antineuralgic, diuretic, expectorant, hypertensive properties. However, hardly, any data is available regarding effects of nut oil on platelet function. In this study, fibrinolytic activity and effect on platelet aggregation were investigated. Method: P. gerardiana nut oil was extracted by using n-Hexane and then concentrated by rotary evaporator. Antithrombotic and fibrinolytic activities were evaluated on blood clot formation. Effects on platelet aggregation of the oil were determined based on collagen or epinephrine induced platelet aggregation. Results: P. gerardiana caused blood clot lysis in-vitro. P. gerardiana nut oil inhibited collagen dependent platelet aggregation while accelerated the epinephrine dependent platelet aggregation. In vitro whole blood coagulation was also reduced. In vivo P. gerardiana nut oil has no significant effect on blood cell indices.

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“…In the present case, a platelet aggregation test showed an impaired responsiveness to epinephrine with normal coagulogram. Even if a depressed responsiveness to epinephrine in platelets from healthy subject has been reported, this condition can explain the initial subdural haematomas and the massive bleeding during the surgery [8,16]. Another explanation could be a disseminated intravascular coagulopathy during surgery, but this does not explain the initial haematomas.…”

Section: Discussionmentioning

confidence: 99%

Proteus syndrome revealing itself after the treatment of a bilateral subdural haematoma

et al. 2013

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Incidence of Nonresponsiveness to Epinephrine in Platelets from Healthy Humans

Cited by 9 publications

References 6 publications

Evaluation of platelet function and lack of response to epinephrine in pregnant women

Evaluation of platelet function and lack of response to epinephrine in pregnant women

A preliminary investigation of in vitro anti-thrombotic and anti-platelet activity of Pinus Gerardiana

Proteus syndrome revealing itself after the treatment of a bilateral subdural haematoma

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