Incidence of oral lichen planus in perimenopausal women: A cross-sectional study in Western Uttar Pradesh population

Mohan, Ravi Prakash Sasankoti; Gupta, Akanksha; Kamarthi, Nagaraju; Malik, Sangeeta; Goel, Sumit; Gupta, Swati

doi:10.4103/jmh.jmh_34_17

Cited by 25 publications

(27 citation statements)

References 20 publications

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“…16 A case control study conducted in a dental hospital found that in a sample of 365 postmenopausal women with routine dental complaints, 27.1% women had dry mouth, 25.8% had mucosal burning or pain sensation, 6.3% had breath change and 3.6% had change in taste. 11,17 15 of 82 women had oral lichen planus, which was higher than two previous studies having rates of 10.9% and 13.75% of patients respectively. 11…”

Section: Discussioncontrasting

confidence: 51%

Pattern of dermatological involvement in early postmenopausal period: a cross sectional study

et al. 2020

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Background: The high burden of menopausal symptoms notwithstanding, there is a paucity of published work evaluating its impact specifically on the skin and mucosa. With high incidence of underreported cases in developing countries, active screening of all women is essential for accurate assessment of prevalence of cutaneous features, as highlighted by this study. The objective of this study is to assess clinical patterns of dermatosis in menopausal women.Methods: A cross‑sectional study conducted in the dermatology department conducted on postmenopausal patients below 65 years having dermatoses after taking their written consent. Data analysis using SPSS 20.0.Results: Of 350 postmenopausal women, 165 had genital involvement, atrophic vaginitis (41.21%) being the most common manifesting typically as vaginal dryness. Of 82 women having oral complaints, 42.7% women had complaints of pain or difficulty swallowing in the absence of mucosal lesions. Of the total sample size, 34% women had had female pattern hair loss, maximum women with grade I-2 (45.4%) and I-3 (36.13%). Two key findings which we did not find previous records of included incidence of keratoderma climactericum (2.29%) and hirsutism in early menopause which we found to be 8%. It is important to note that only 28% of women were aware that their complaints were related to menopause or chose to seek active treatment for existing complaints.Conclusions: This study highlights the various clinical patterns of postmenopausal dermatoses to raise awareness in dermatologists and gynecologists for prompt diagnosis, treatment and patient education.

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Section: Discussioncontrasting

confidence: 51%

Pattern of dermatological involvement in early postmenopausal period: a cross sectional study

et al. 2020

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“…OLP in peri and post-menopausal women can be mediated by the declined level of estrogen and Progesterone directly or indirectly through causing depression that can trigger LP. 19 Estrogen increases the activity of the enzyme responsible for activating Vit D, so declining estrogen levels during the menopausal transition could lead to symptoms of Vit D deficiency 20 . Hence, there is a strong correlation between vit D deficiency and the incidence of lichen planus.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive effect of Vit D to local cortisone in treating oral lichen planus lesions in menopausal and post- menopausal Egyptian women.

Shoukheba

2020

Egyptian Dental Journal

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This study was conducted to evaluate the effect of Vitamin D (Vit D) supplementation to topical corticosteroids in the treatment of oral lichen planus (OLP) among postmenopausal women. Thirty post-menopaus al women, their ages ranging between 45-65 years, diagnosed with any form of Oral lichen planus and presenting with serum 25 Hydroxyvitamin D levels below 30ng/ ml were randomly allocated into one of two groups (15 patients each) and treated as follows: The control group I, received topical cortisone alone; The experimental group II, who were treated with topical cortisone supplemented with Vit D every week for one month. Serum level of TNF-α, clinical and pain scores were carried out at the time of the initial visit and at 2, 4, and 6 weeks. Results showed improvement in clinical score. Both treatment modalities resulted in a statistically significant decrease in pain score, and TNF-α (P < 0.001) compared to the baseline values. There was no statistically significant difference between the two groups (P > 0.05) at any evaluation period for the pain score, while TNF-α showed statistically significant differences at 4 weeks only in favor to group II (P < 0.05). Conclusion: Within the limitation of this study, it can be concluded that Vit D supplementation to conventional therapy can help in treating OLP among post-menopausal women. Attention must be given to educate the women in this critical age to pay attention to Vit D deficiency to avoid such serious diseases.

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“…Larsen, Johansen, Reibel, Zachariae, and Pedersen (2017) suggest that gender hormones may be involved in the pathogenesis by making the mucosa more susceptible to oral diseases such as OLP. Moreover, Mohan et al (2017) report that LP in perimenopausal women can be mediated by declined levels of oestrogen and progesterone causing depression that can trigger OLP.…”

Section: Discussionmentioning

confidence: 99%

Psychological disorders and quality of life in oral lichen planus patients and a control group

et al. 2019

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Objectives Oral lichen planus (OLP) is a common disease whose aetiopathogenesis is linked to psychological disorders. This study aims to determine the influence of anxiety and depression in OLP patients, define the perception of quality of life in these patients and check for potential differences between atrophic/ ulcerative and reticular lesions. Materials and Methods A group of 48 OLP patients and a control group of 40 patients were selected. In order to assess anxiety, depression and quality of life, Hospital Anxiety and Depression Scale (HADS) and Oral Health Impact Profile 14 (OHIP‐14) tests were completed. Results OLP patients showed higher scores on HADS (anxiety p < 0.01, depression p < 0.05) and OHIP‐14 (physical pain p < 0.05, psychological discomfort p = 0.001). Patients with reticular lesions obtained higher scores in HADS (anxiety p = 0.001, depression p < 0.001), whereas patients with atrophic/ ulcerative lesions obtained higher scores in OHIP‐14 (p = 0.02). Conclusions Psychological disorders play an important role as a trigger for OLP and are responsible for many relapses. Psychological support would be advisable in order to improve their mental health, as this would have a positive impact on their quality of life and would lead to a better progression of the disease.

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Incidence of oral lichen planus in perimenopausal women: A cross-sectional study in Western Uttar Pradesh population

Cited by 25 publications

References 20 publications

Pattern of dermatological involvement in early postmenopausal period: a cross sectional study

Pattern of dermatological involvement in early postmenopausal period: a cross sectional study

Adjunctive effect of Vit D to local cortisone in treating oral lichen planus lesions in menopausal and post- menopausal Egyptian women.

Psychological disorders and quality of life in oral lichen planus patients and a control group

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