Incidence of penicillin-resistant streptococcus pneumoniae in Japan, 1993–1995

Ubukata, Kimiko; Asahi, Yasuko; Okuzumi, Katsuko; Konno, Masatoshi

doi:10.1007/bf02350645

Cited by 39 publications

(20 citation statements)

References 16 publications

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“…Since the early 1990s, isolations of PEN-nonsusceptible strains in RTI and acute otitis media have increased dramatically throughout Japan, particularly in young children (41). Currently, genotypically proven gPISP and gPRSP have been isolated in 2002 at rates of 33.0 and 54.9%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002

Ubukata

Chiba

Hasegawa

et al. 2004

Antimicrob Agents Chemother

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The antibiotic susceptibilities, genotypes of penicillin (PEN)-binding protein genes (pbp), and serotype distributions of Streptococcus pneumoniae isolates from meningitis patients were investigated by a nationwide surveillance group in Japan between 1999 and 2002. We analyzed 146 isolates from children (<17 years old) and 73 from adults (>18 years old). Isolates with or without abnormal pbp1a, pbp2x, or pbp2b genes identified by PCR were classified into six genotype patterns and 90% MIC (MIC 90 ) values for PEN: (i) strains with three normal genes (17.2% of isolates; MIC 90 , 0.031 g/ml); (ii) strains with abnormal pbp2x (22.1%, 0.063 g/ml); (iii) strains with abnormal pbp2b (1.0%, 0.125 g/ml); (iv) strains with abnormal pbp2x and pbp2b (7.4%, 0.25 g/ml); (v) strains with abnormal pbp1a and pbp2x (12.7%, 0.25 g/ml); and (vi) strains with three abnormal PBP genes (39.7%, 4 g/ml), which are termed genotypic PEN-resistant S. pneumoniae (gPRSP). Panipenem, a carbapenem, showed an excellent MIC 90 (0.125 g/ml) against gPRSP, followed by meropenem and vancomycin (0.5 g/ml), cefotaxime and ceftriaxone (1 g/ml), and ampicillin (4 g/ml). Strains of gPRSP were significantly more prevalent in children (45.2%) than in adults (27.4%). The most frequent serotypes were 6B, 19F, 23F, 6A, and 14 in children and 23F, 22, 3, 10, 6B, and 19F in adults. Serotypes 6B, 6A, 19F, 23F, and 14 predominated among gPRSP. In children, 7-and 11-valent pneumococcal conjugate vaccines would cover 76.2 and 81.3% of isolates, respectively, although coverage would be lower in adults (43.9 and 56.0%, respectively). These findings suggest the need for early introduction of pneumococcal conjugate vaccines and continuous bacteriological surveillance for meningitis.Streptococcus pneumoniae is a common etiologic agent of serious invasive infections, with high morbidity and mortality in children and adults, such as meningitis, septicemia, and pneumonia (23, 29). The evolution of strains of S. pneumoniae resistant to penicillin G (PEN) and broad-spectrum cephalosporin antibiotics has created difficulties worldwide in selecting an appropriate chemotherapeutic agent (2).Surveillance studies of antibiotic susceptibility, serotype distribution of causative strains, and mortality rate in meningitis have been carried out nationwide in many countries (8,11,15,20,21,28,33,36,39,43).In Japan, prevalence of PEN-resistant S. pneumoniae (PRSP) among clinical isolates from acute otitis media and respiratory tract infections (RTIs) has been increasing rapidly, especially in younger children (40,41). In parallel with overall increases in incidence of PRSP, meningitis caused by PRSP is being reported increasingly throughout Japan (4). As investigators in that country, we felt that nationwide surveillance had become crucial given increasing isolation of resistant strains that could cause meningitis, including PRSP, as well as ampicillin (AMP)-and cephalosporin-resistant strains of Haemophilus influenzae type b, the most frequent etiologic agent of bacterial meningitis. I...

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Section: Discussionmentioning

confidence: 99%

“…In Japan, prevalence of PEN-resistant S. pneumoniae (PRSP) among clinical isolates from acute otitis media and respiratory tract infections (RTIs) has been increasing rapidly, especially in younger children (40,41). In parallel with overall increases in incidence of PRSP, meningitis caused by PRSP is being reported increasingly throughout Japan (4).…”

mentioning

confidence: 99%

Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002

Ubukata

Chiba

Hasegawa

et al. 2004

Antimicrob Agents Chemother

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“…After developing lytA-specific PCR (Rudolph et al, 1993), many researchers have successfully detected or identified S. pneumoniae by this method using purified DNA as a template (Gillespie et al, 1994 ;Hassan-King et al, 1994 ;Ubukata et al, 1996). Recently, Whatmore et al (1996) reported that a subset of S. mitis and S. oralis strains isolated were positive for this gene by PCR.…”

Section: Discussionmentioning

confidence: 99%

Genetic approaches to the identification of the mitis group within the genus Streptococcus The DDBJ accession numbers of the superoxide dismutase genes described in this paper are shown in Table 1 T1 .

et al. 1999

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The usefulness and reliability of partial sequence analysis of the manganesedependent superoxide dismutase gene (sodA), autolysin (lytA) gene amplification and species-specific PCR based on the D-alanine :D-alanine ligase (ddl) gene for differentiating each member of the mitis group of the genus Streptococcus was investigated. On the phylogenetic tree based on sodA partial sequences (366 bp) from 96 strains, including all species currently within the mitis group isolated in different geographic areas (mainly Japan and the UK), eight well separated clusters were generated corresponding to recognized species, and all strains fell into those clusters to which they had also been assigned by DNA-DNA hybridization. The Streptococcus pneumoniae sub-cluster was located within the Streptococcus mitis cluster, but the sodA gene of S. pneumoniae was very conserved and therefore could be separated from all other species examined. Furthermore, the lytA gene amplification approach could also be used to differentiate S. pneumoniae from other species. The species-specific amplification product of the ddl gene was successfully detected in Streptococcus sanguinis and Streptococcus gordonii, but failed to be detected in some strains of Streptococcus oralis including the type strain and S. mitis. We conclude that the partial sequence analysis of the sodA gene could be applied globally as a reliable and easy method for the accurate identification of all species currently within the mitis group.

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“…All of the studies were performed in the pre-PCV13 period. The study designs could be categorized into case series of pneumococcal LRTI (15,16), prospective surveillance of pneumococcal LRTI or IPD cases (1,(17)(18)(19)(20), and laboratory-based pneumococcal strain surveillance (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). One of the prospective surveillance studies of the LRTI referred to the Japanese Respiratory Society (JRS) guidelines for the management of community-acquired pneumonia in adults (36) as diagnostic criteria for LRTI (17).…”

Section: Resultsmentioning

confidence: 99%

Serotype Replacement in Adult Pneumococcal Pneumonia after the Introduction of Seven-Valent Pneumococcal Conjugate Vaccines for Children in Japan: a Systematic Literature Review and Pooled Data Analysis

et al. 2017

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Incidence of penicillin-resistant streptococcus pneumoniae in Japan, 1993–1995

Cited by 39 publications

References 16 publications

Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002

Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002

Genetic approaches to the identification of the mitis group within the genus Streptococcus The DDBJ accession numbers of the superoxide dismutase genes described in this paper are shown in Table 1 T1 .

Serotype Replacement in Adult Pneumococcal Pneumonia after the Introduction of Seven-Valent Pneumococcal Conjugate Vaccines for Children in Japan: a Systematic Literature Review and Pooled Data Analysis

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