Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma

Stützer, Bianca; Simon, Karin; Lutz, Hans; Majzoub, M.; Hermanns, W.; Hirschberger, Johannes; Sauter‐Louis, Carola; Hartmann, Katrin

doi:10.1016/j.jfms.2010.09.015

Cited by 53 publications

(45 citation statements)

References 30 publications

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“…Whereas 59% of all cats with lymphoma or leukemia were FeLV antigen-positive in one German study from 1980 to 1995, only 20% of the cats were FeLV antigen-positive in the years 1996 to 1999 in the same university veterinary clinic (Hartmann et al, 1998). A recent study in this area confirmed the low prevalence of FeLV antigenemia in cats with lymphoma; in the study, 16 of 77 cats (21%) were FeLV antigen-positive (Stützer et al, 2011). In a study in the Netherlands, only four of 71 cats with lymphoma were FeLV-positive, although 22 of these cats had mediastinal lymphoma, which was previously highly associated with FeLV infection (Teske et al, 2002).…”

Section: Feline Leukemia Virus Infectionmentioning

confidence: 63%

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Hartmann¹

2011

Veterinary Immunology and Immunopathology

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155

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Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with a global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FIV can cause an acquired immunodeficiency syndrome that increases the risk of developing opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without any health problems. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia) and lead to secondary infectious diseases caused by suppressive effects of the virus on bone marrow and the immune system. Today, FeLV is less important as a deadly infectious agent as in the last 20 years prevalence has been decreasing in most countries.

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Section: Feline Leukemia Virus Infectionmentioning

confidence: 63%

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Hartmann¹

2011

Veterinary Immunology and Immunopathology

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154

155

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“…A low percentage of cats tested positive for feline retroviruses. None of feline skin lymphomas in other reports was associated with progressive FeLV infection, which implies a negligible role of FeLV in subcutaneous lymphomagenesis, and most likely reflects the decreasing prevalence of FeLV among cats in most countries and among cats with lymphomas in particular …”

Section: Discussionmentioning

confidence: 76%

“…Prevalence of progressive FeLV infection decreased in the general cat population due to routine screening of cats, separation of progressively infected cats and preventative FeLV vaccination programs since the 1990s. Consequently the number of FeLV‐associated lymphomas declined as well …”

Section: Introductionmentioning

confidence: 99%

Patient characteristics, histopathological findings and outcome in 97 cats with extranodal subcutaneous lymphoma (2007–2011)

Meichner

Bomhard²

2014

Vet Comparative Oncology

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This study describes epidemiologic, clinical, macro-and microscopic tumour characteristics and outcome in 97 cats with subcutaneous lymphoma, an uncommon variant of feline extranodal lymphoma. Middle-aged (median 11 years), male (60.8%), Domestic Shorthair cats (89.7%) were commonly affected. Most tumours presented as a painless, firm, subcutaneous nodule or mass, with predilection to the lateral thoracic or abdominal wall, and the interscapular region. Deep subcutaneous invasion with extension into superficial or underlying tissues, extensive central areas of necrosis and peripheral inflammation were characteristic histopathological findings. Prevalence of retroviral infection was low. Local relapses after therapy were common (43.5%), and 32.2% had distant involvement later in course. Median overall survival was 148 days. Subcutaneous lymphoma should be considered a rare but important differential diagnosis for a subcutaneous mass in cats. Tumours show an aggressive biological behaviour. Treatment options including prognosis should be investigated in further studies.

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“…Proviral DNA was detected in formalin-fixed, paraffin-embedded tumor tissue in 7/11 FeLV-negative cats with lymphoma [43]. However, other groups found evidence of provirus in only 1/22 [45] and in 0/50 FeLV antigen-negative lymphomas [47]. …”

Section: Clinical Signsmentioning

confidence: 99%

Clinical Aspects of Feline Retroviruses: A Review

Hartmann¹

2012

Viruses

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301

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Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia), and lead to secondary infectious diseases caused by suppressive effects of the virus on bone marrow and the immune system. Today, FeLV is less commonly diagnosed than in the previous 20 years; prevalence has been decreasing in most countries. However, FeLV importance may be underestimated as it has been shown that regressively infected cats (that are negative in routinely used FeLV tests) also can develop clinical signs. FIV can cause an acquired immunodeficiency syndrome that increases the risk of opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without any health problems. This article provides a review of clinical syndromes in progressively and regressively FeLV-infected cats as well as in FIV-infected cats.

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Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma

Cited by 53 publications

References 30 publications

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Patient characteristics, histopathological findings and outcome in 97 cats with extranodal subcutaneous lymphoma (2007–2011)

Clinical Aspects of Feline Retroviruses: A Review

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