Incidence of post-thrombotic syndrome in patients with previous pulmonary embolism

Bova, Carlo; Rossi, Vincenza; Ricchio, Roberto; Greco, Antonio; Bloise, Antonio; Daniele, Filomena; Greco, Francesco; Noto, Alfonso

doi:10.1160/th04-03-0178

Cited by 12 publications

(2 citation statements)

References 15 publications

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“… 17 Finally, we combined ‘signs of PTS’ with the ‘type of VTE’ factor, so as to prevent inappropriate interactions: post-thrombotic syndrome almost exclusively occurs in tandem with DVT, rather than with PE. 18 This leaves 12 factors in our reduced model.…”

Section: Methods and Analysismentioning

confidence: 99%

Determinants of treatment duration in the prevention of recurrent venous thromboembolism: a protocol for a balanced vignette experiment

2017

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IntroductionVenous thromboembolism (VTE) is a condition that annually occurs in approximately 1‰ of the world’s population. Patients who have already had a VTE are at elevated risk for a recurrent VTE. Recurrent events increase the risk of long-term sequelae and can be fatal. Adequate secondary prophylaxis is thus needed to prevent such events. Patients with VTE are often prone to bleeding, and pharmacological prophylaxis exacerbates bleeding risk. Expert opinions on the optimum duration of secondary prophylaxis in VTE still vary substantially. The existence of treatment guidelines has not led to uniformity of VTE secondary prophylaxis strategies, which means that physicians still adhere to individual risk calculi in determining treatment duration.Methods and analysisThe aim of this study is to establish what factors lie at the root of this variance in VTE secondary prophylactic treatment strategies, and what risk factors are deemed of particular importance in determining the perceived risks and benefits of variable treatment durations. To do this, we created a survey based on a D-efficient and G-efficient balanced experimental vignette design. This protocol covers all aspects of how this survey was set up and how it was implemented. The analysis of the experimental data will be carried out using mixed-effects methods, which are beneficial in scenarios with high interindividual variance and correlated (eg, repeated-measures) responses. We propose the use of maximal random effects structures insofar as possible.Ethics and disseminationAll data are de-identified, and any identifying characteristics of the respondents will not be reported in a final manuscript or elsewhere. A paper describing the expert interviews is currently under peer review. A manuscript that contains the analysis of the results of the experiment described in this protocol is being drafted, and will also be submitted to a peer-reviewed journal.

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Section: Methods and Analysismentioning

confidence: 99%

Determinants of treatment duration in the prevention of recurrent venous thromboembolism: a protocol for a balanced vignette experiment

2017

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“…However, literature from other studies reported up to 80% incidence of PTS in patients presenting with distal (calf) DVT; thus suggesting that this type of DVT may be associated with a considerable risk of PTS development [52, 53]. Moreover, pulmonary embolism without concomitant ultrasonographically detectable DVT does not predispose patients to PTS [54]. …”

Section: Risk Factors Evident At the Time Or During Initial Treatmmentioning

confidence: 99%

Evaluating the Role of Compression Stockings in Preventing Post thrombotic Syndrome: A Review of the Literature

et al. 2012

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Background. Postthrombotic syndrome (PTS) is a burdensome and costly complication of deep vein thrombosis (DVT). Up to 50% of patients with DVT will develop the disease within two years following the diagnosis of acute DVT. Various risk factors for developing PTS have been identified and different modalities have been used to prevent its development. Compression stockings have been studied for the prevention of PTS in patients diagnosed with proximal DVT. Methods. MEDLINE and EMBASE databases were searched to identify relevant original articles. Results. Several trials including two metaanalyses have examined the role of compression stockings for the prevention of PTS. Although most trials showed significant reduction in the development of PTS with the use of compression stockings, limitations in study design prevent the generalizability of the data. Two studies supported an individualized tailored duration especially in patients at low risk for developing the syndrome. A randomized double-blind placebo-controlled trial involving 800 patients is currently ongoing and may confirm the results of older studies. Conclusions. Clinical trials support the use of compression stockings in patients diagnosed with proximal DVT for the prevention of PTS.

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Postthrombotic Syndrome

Rabinovich

Kahn

2015

PanVascular Medicine

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Incidence of post-thrombotic syndrome in patients with previous pulmonary embolism

Cited by 12 publications

References 15 publications

Determinants of treatment duration in the prevention of recurrent venous thromboembolism: a protocol for a balanced vignette experiment

Determinants of treatment duration in the prevention of recurrent venous thromboembolism: a protocol for a balanced vignette experiment

Evaluating the Role of Compression Stockings in Preventing Post thrombotic Syndrome: A Review of the Literature

Postthrombotic Syndrome

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