Incidence of preeclampsia in pregnant Swiss women

Purde, Mette-Triin; Baumann, Marc; Wiedemann, Ute; Nydegger, Urs E.; Risch, Lorenz; Surbek, Daniel; Risch, Martin

doi:10.4414/smw.2015.14175

Cited by 24 publications

(30 citation statements)

References 55 publications

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“…4 Compared to controls, White cases were more likely to be nulliparous (81.11% versus 50.11%, P < 0.05), and Hispanic cases were older than controls (28.61 years on average versus 26.22 years, P < 0.05), as presented in Table 1. Cases of White and Hispanic origin were heavier at or near the time of specimen collection than controls (76.20 kg on average versus 70.02 kg in Whites and 76.33 kg versus 67.22 kg in Hispanics, P < 0.05, respectively).…”

Section: Resultsmentioning

confidence: 95%

“…1,2 Preeclampsia is heterogeneous in onset and severity of clinical manifestations. 3 Preeclampsia occurring at <32 weeks of pregnancy, also known as early-onset preeclampsia with an incidence range of 0.2%-1.4%, 4 carries a disproportionately higher risk of maternal and infant mortality and therefore is considered a more severe form of the disease than preeclampsia occurring later in pregnancy. 1,3 Angiogenesis is the process of new blood vessel formation and the growth of new blood vessels from existing blood vessels.…”

Section: Introductionmentioning

confidence: 99%

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Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

Yang

Pearl

DeLorenze

et al. 2016

American Journal of Obstetrics and Gynecology

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BACKGROUND Little is known about racial-ethnic differences in the distribution of maternal serum levels of angiogenic and antiangiogenic factors and their associations with early-onset preeclampsia. OBJECTIVE To investigate the distribution of mid-trimester maternal serum levels of placental growth factor, soluble endoglin, and soluble vascular endothelial growth factor receptor 1 and their associations with early-onset preeclampsia in Whites, Hispanics, and Blacks. STUDY DESIGN A population-based nested case-control design was used to identify cases and controls of White, Hispanic, and Black origin from a 2000 to 2007 live-birth cohort in five southern California counties. Cases included 197 women (90 Whites, 67 Hispanics, and 40 Blacks) with early-onset preeclampsia defined as hypertension and proteinuria with onset prior to 32 weeks according to hospital records. Controls included a random sample of 2,363 women without early-onset preeclampsia. Maternal serum specimens collected at 15-20 weeks of gestation as part of routine prenatal screening were tested for placental growth factor, soluble endoglin, and soluble vascular endothelial growth factor receptor 1. Serum levels of the three factors were log-normally distributed. Adjusted natural logarithmic means were compared between cases and controls and between racial-ethnic groups. Odds ratios and 95% confidence intervals derived from logistic regression models were calculated to measure the magnitude of the associations. RESULTS Cases showed lower adjusted logarithmic means of placental growth factor but higher adjusted logarithmic means of soluble endoglin than controls across all three groups (P < 0.05). Cases also had higher adjusted means of soluble vascular endothelial growth factor receptor 1 than controls in Whites (7.75 log pg/mL versus 7.52 log pg/mL, P < 0.05) and Hispanics (7.73 log pg/mL versus 7.40 log pg/mL, P < 0.05) but not in Blacks (7.85 log pg/mL versus 7.69 log pg/mL, P = 0.47). Blacks were found to have higher levels of placental growth factor in both cases and controls when compared to Whites and Hispanics (adjusted means: 4.69 log pg/mL and 5.20 log pg/mL in Blacks, 4.08 log pg/mL and 4.78 log pg/mL in Whites, and 3.89 log pg/mL and 4.70 log pg/mL in Hispanics, respectively, P < 0.05). Hispanic cases had the highest adjusted mean of soluble endoglin compared to White and Black cases (9.24 log pg/mL, 9.05 log pg/mL, and 8.93 log pg/mL, respectively, P < 0.05). The weakest association of early-onset preeclampsia with placental growth factor and soluble endoglin was observed in Blacks. The adjusted odds ratio per log pg/mL increase of the two analytes were 0.219 (95% confidence interval, 0.124-0.385)and 5.02 (95% confidence interval, 2.56-9.86) in Blacks in comparison to 0.048 (95% confidence interval, 0.026-0.088) and 36.87 (95% confidence interval, 17.00-79.96) in Whites (P < .05) and 0.028 (95% confidence interval, 0.013-0.060) and 86.68 (95% confidence interval, 31.46-238.81) in Hispanics (P < .05), respectively. As for soluble ...

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

Yang

Pearl

DeLorenze

et al. 2016

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

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“…Previously described potential risk factors for developing preeclampsia are nulliparity, advanced maternal age, obesity, multiple gestations, prior preeclampsia, and preexisting diseases e.g. diabetes mellitus and chronic hypertension (4,5). It can be assumed they are similar to those characteristic for developing HELLP syndrome.…”

Section: Introductionmentioning

confidence: 99%

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia

M¹,

Krištúfková²,

Némethová³

et al. 2019

BLL

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OBJECTIVE: Hemolysis, Elevated Liver Enzymes, Low Platelets syndrome (HELLP syndrome) is one of the actively haunted maternal morbidity through Slovak Obstetric Survey System (SOSS), the organisation for surveillance of severe maternal morbidity and mortality in Slovakia. METHODS: The questionaires were sent in 55 Obstetric Units in Slovakia. The analyzed and here presented data had been collected cases those happened in the period from 1.1.2012 till 31.12.2014. Controls were women from SR during observed years, who delivered without HELLP syndrome. RESULTS: The return rate of questionnaires was 89.67 %, thus covering 146 972 deliveries during the study period in Slovakia. The exact incidence of HELLP syndrome was 0.63/1000 deliveries (CI 95 % 0.51-0.78). Risk factors were age > 30 (OR = 1.63), nuliparous (OR = 2.96), pregnancy after assisted reproduction technology (OR = 8.29) and multiple pregnancy OR = 9.19). The mean gestation age at delivery was 33.8th weeks. Vaginal delivery was by 10 (10.8 %) patients with HELLP syndrome and in the 83 (89.2 %) patients pregnancy was terminated with acute caesarean section. There were reported 45 050 cases (30.7 %) of the caesarean section in the control group throughout the study period. CONCLUSION: The older age, nulliparity, multiple pregnancy and pregnancy after assisted reproduction techniques was identifi ed as a signifi cant risk factors of HELLP syndrome (Tab. 5, Fig. 1, Ref.

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“…Preeclampsia (PE) and other hypertensive disorders during pregnancy occur in ~ 2–8% of pregnant women [ 1 ]. Currently, no treatment exists to prevent the progression of the disease after its clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Afamin: an early predictor of preeclampsia

Köninger

Enekwe

Mach

et al. 2018

Arch Gynecol Obstet

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PurposeOxidative stress is involved in the pathogenesis of hypertensive disorders such as preeclampsia (PE) and associated with the human vitamin E-binding protein afamin. The aim of this study was, therefore, to analyse afamin in the first trimester of patients developing PE later in pregnancy and in control subjects without pregnancy complications.MethodsIn this retrospective study, 137 serum samples from the first trimester of pregnancy were analysed in a case–control study design. 39 patients developed PE (10 patients with early-onset and 29 patients with late onset disease) and 98 women had an uncomplicated pregnancy. Mann–Whitney U test, t test, logistic regression and ROC analyses were performed for statistical evaluation.ResultsPregnant women developing PE presented with higher afamin concentrations in the first trimester [median 101.81 mg/L; interquartile range (IQR) 88.94–113.26] compared to subjects with uncomplicated pregnancy (median 86.40; IQR 75.26–96.92; p < 0.001). After adjusting for confounders, the odds ratio per afamin standard deviation was 1.60 (95% CI: 1.04–2.58; p = 0.04). An afamin threshold concentration of 87.8 mg/L exhibited the best sensitivity (79.5%) and specificity (57.1%) in predicting PE. Subgroup analysis of early- and late-onset disease resulted in substantially higher afamin concentrations in women with developing late-onset PE compared to controls (p < 0.001) with an odds ratio per afamin standard deviation of 1.62 (95% CI: 0.98–2.70; p = 0.06).ConclusionsSerum afamin concentrations are elevated in the first trimester among patients developing PE compared to controls. Substantial differences were observed mainly among patients with late-onset PE.

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Incidence of preeclampsia in pregnant Swiss women

Abstract: The incidence of preeclampsia in Switzerland is in line with frequencies observed elsewhere in the world. Extrapolation to a national level indicates that about 1,911 (range 1,340-2,713) preeclampsia cases per year can be expected to occur in Switzerland.

Cited by 24 publications

References 55 publications

Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia

Afamin: an early predictor of preeclampsia

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