Incidence of Pregnancy-Associated Cancer in Denmark, 1977–2006

Eibye, Simone; Kjær, Susanne K.; Mellemkjær, Lene

doi:10.1097/aog.0b013e3182a057a2

Cited by 136 publications

(149 citation statements)

References 18 publications

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“…8,9 The upward trend of breast cancer incidence and the postponing of childbearing have increased the numbers of BCP cases. 6,7,10,11 Approximately 1 in 5 breast cancers diagnosed in women aged 25 to 29 years is associated with a pregnancy, diagnosed either during pregnancy or during the first post-partum year. The reported occurrence of breast cancer diagnosed during pregnancy ranges from 2.4 to 7.3 per 100 000 pregnancies in population-based investigations.…”

Section: Epidemiologymentioning

confidence: 99%

“…The reported occurrence of breast cancer diagnosed during pregnancy ranges from 2.4 to 7.3 per 100 000 pregnancies in population-based investigations. 6,7,10,11 A Danish study found that 81% of pregnancies affected with breast cancer were terminated during the first trimester, whereas other reports found that only 19% of all BCPs were diagnosed in the Breast cancer during pregnancy (BCP), although rare, is becoming more common and treatment should be as similar as possible to that for nonpregnant young patients with breast cancer. A group of specialists convened to review current guidelines and provide guidance on how recent advances in breast cancer diagnosis and treatment can be adapted for pregnant patients.…”

Section: Epidemiologymentioning

confidence: 99%

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Breast Cancer Diagnosed During Pregnancy

et al. 2015

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Breast cancer during pregnancy (BCP), although rare, is becoming more common and treatment should be as similar as possible to that for nonpregnant young patients with breast cancer. A group of specialists convened to review current guidelines and provide guidance on how recent advances in breast cancer diagnosis and treatment can be adapted for pregnant patients. The majority of patients with BCP will be considered for treatment during the pregnancy. Premature delivery should be avoided whenever possible. Most treatments, including sentinel lymph node biopsy, systemic therapy with taxanes, platinum agents, or dose-dense treatment can be safely given during pregnancy, after careful risk/benefit assessment for mother and child. Chemotherapy is contraindicated during the first trimester because of a higher risk of fetal malformations but is feasible in the second and third trimesters. Other treatments such as radiation therapy or anti-human epidermal growth receptor 2 treatment are in general not indicated during pregnancy but might be considered in some instances. Patient data should be collected in a systematic way whenever possible.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Breast Cancer Diagnosed During Pregnancy

et al. 2015

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“…For a cancer to be categorized as pregnancyassociated neoplasia, it must be diagnosed during pregnancy or up to 1 year after delivery. The incidence rate for this type of cancer ranges from 17 to 38 cases/100.000 births (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

High-grade cervical dysplasia in pregnancy – psychological and medical challenges

Balalau¹,

Sima²,

Bacalbaşa³

et al. 2017

JMMS

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Despite being rare, the incidence of pregnancy-related cancer is expected to rise as women continue to delay childbearing and give birth later in their reproductive years. In this broad category, tumors like breast cancer, dermatological neoplasia and cervical cancer are most common and tend to arise in women of childbearing age. All pregnant women with clinical and cytologic suspicion of cervical cancer, except for squamous atypia or low-grade squamous intraepithelial lesions, should undergo colposcopy, with or without biopsy, the latter being avoided if possible due to possible complications which, although rare, may involve preterm labor initiation.Some studies have attempted to assimilate comparable results of USG with MRI during the gestational period by determining the sensitivity, specificity, and accuracy of trans-rectal ultrasound (TRUS) in comparison to magnetic resonance imaging (MRI). In order to identify the proper way to diagnose and treat the disease, because of the complexity due to pregnancy, a multidisciplinary team consisting of a gynecologist, medical and surgical oncologist, and radiologist should be assembled. Both maternal and fetal wellbeing should be taken into consideration when the medical team must choose among termination of pregnancy, delay of maternal treatment, and iatrogenic preterm delivery. Psychological counseling also plays an important role and due to the sensitivity of the issue, should continue through gestation and the postpartum.In order to develop optimal guidelines for diagnosis, treatment, and outcome issues, large scale prospective studies are needed, but feasibility may be limited due to the scarcity of cervical cancer cases associated with pregnancy. Bălălău OD. et al. 25

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“…Others define the postpartum diagnosis from 6 months to 2 years from delivery [6,7]. Norwegian, Danish and Swedish studies indicate melanoma as the most common malignancy diagnosed during pregnancy followed by ovarian and breast cancers [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…A total of 336 young women were diagnosed with melanoma of whom 34 (10.1 %; aged 32.5±5.6 years; including two patients with in situ melanoma and one patient with duplex melanoma) were defined as PAM [9]. We also analyzed the data of age-and tumor stage-matched NPAM women (n=32, aged 32.7±7.11 years) and men (n=32, aged 33.8±4.9 years).…”

Section: Introductionmentioning

confidence: 99%

Retrospective Analysis of Clinicopathological Characteristics of Pregnancy Associated Melanoma

Fábián

Tóth

Somlai

et al. 2015

Pathol. Oncol. Res.

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Pregnancy associated melanoma (PAM) by definition appears during pregnancy or within 1 year after delivery. In this retrospective study we analysed the pathological characteristics and survival rate of PAM and matched the data with non-pregnant age- and stage-matched control patients. Between 2003 and 2014, 34 pregnant women (aged 32.5 ± 5.6 years) were diagnosed with melanoma at the Department of Dermatology, Venereology and Dermatooncology of the Semmelweis University. During the pathological process histologic subtype, Breslow thickness and Clark level, tumor cell type, mitotic rate, peritumoral inflammation, as well as ulceration, regression, necrosis, vascular invasion and presence of satellite were analyzed and related to clinical data. Primary tumor location and clinical staging, disease course, local recurrence and metastases, 5-year survival rate, other tumor development before or after the diagnosis of melanoma have also been documented. We found no difference in all parameters between pregnant and non-pregnant melanoma cases except peritumoral inflammation which was higher in PAM group, moreover the presence of mild inflammation was significantly higher in PAM group compared to non-pregnancy associated melanoma (NPAM) women group.

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Incidence of Pregnancy-Associated Cancer in Denmark, 1977–2006

Abstract: III.

Cited by 136 publications

References 18 publications

Breast Cancer Diagnosed During Pregnancy

Breast Cancer Diagnosed During Pregnancy

High-grade cervical dysplasia in pregnancy – psychological and medical challenges

Retrospective Analysis of Clinicopathological Characteristics of Pregnancy Associated Melanoma

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