Incidence of Renal Lesions in Polycythaemia

Brandt, P. W. T.; Dacie, J. V.; Steiner, R. E.; Szur, L.

doi:10.1136/bmj.2.5355.468

Cited by 15 publications

(5 citation statements)

References 33 publications

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“…A variety of renal lesions have been documented in association with polycythaemia (Brandt, Dacie, Steiner, and Szur, 1963;Rosse, Waldmann, and Cohen, 1963). In the high age groups in which this disease occurs, renal function is diminished (de Wardener, 1961) and the reduced glomerula filtration and tubular secretion (Davies and Shock, 1950) (Nugent and Tyler, 1959).…”

Section: Resultsmentioning

confidence: 99%

Hyperuricaemia in Polycythaemia Vera

Denman

Szur

Ansell

1966

Annals of the Rheumatic Diseases

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Section: Resultsmentioning

confidence: 99%

Hyperuricaemia in Polycythaemia Vera

Denman

Szur

Ansell

1966

Annals of the Rheumatic Diseases

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“…med 7., 1961 ;Hillas Smith, 1963;Brandt et al, 1963). Although Cotes and Lowe (1963) did not find a significant increase in haemoglobin concentration in patients with renal artery stenosis, Luke et al (1965) described a case of renal artery stenosis with increased haemoglobin concentration and red-cell volume in which nephrectomy cured the hypertension and restored the haemoglobin concentration to normal.…”

Section: Renin In Relation To Haemoglobin Concentration In Renal Artementioning

confidence: 99%

Plasma renin concentration in human hypertension . II. Renin in relation to aetiology.

Brown¹,

Davies²,

Lever³

et al. 1965

BMJ

120

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In previous papers (Brown et al., 1965a(Brown et al., , 1965b we have demonstrated, in clinical hypertension, a close inverse relationship between renin concentration and plasma sodium which appears to be independent of aetiology, the height of the arterial pressure, complications, and treatment. The present communication is concerned with an analysis of renin and sodium in hypertension in relation to aetiology. The methods used in this study are as given previously (Brown et al., 1965b(Brown et al., , 1965d; data on additional cases have been included, but the series is basically that described earlier. Plasma In this condition hypertension is caused by an aldosteronesecreting adrenal cortical adenoma (Conn, 1955;Mader and Iseri, 1955 ;Milne et al., 1957;Conn et al., 1964b). Plasma sodium and total exchangeable sodium are often raised, while potassium is low. Whether all the features of the syndrome can be attributed solely to the excess aldosterone, or whether other hormones produced by the tumour are necessary, has been the subject of discussion (see Ross and Hurst, 1965).The hypertension and increased exchangeable sodium are accompained by depression of plasma renin concentration ; after removal of the tumour, with correction of the hypertension and electrolyte abnormalities, renin rises into the normal range (Brown et al., 1963b(Brown et al., , 1964a(Brown et al., -c, 1965d (Fig. 1).Alternatively, the administration of spironolactone to patients with this syndrome may correct the hypertension and electrolytes without affecting aldosterone secretion (Brown et al., 1963b(Brown et al., , 1964a(Brown et al., , 1964b(Brown et al., , 1964c(Brown et al., , 1965d; plasma renin concentration rises to normal as the sodium falls, emphasizing the interrelationship between renin and sodium, and showing that the effect of the adrenal overactivity on renin concentration is not a direct one but is mediated by the electrolyte abnormalities (Brown et al., 1963b(Brown et al., , 1964a(Brown et al., , 1964c operation in a patient with primary aldosteronism, the values rising after removal of the tumour. Findings similar to those of Kirkendall et al. (1964), but with an occasional result well in the measurable range before operation, were later published by Conn et al. (1964a), who used the extraction procedure of Boucher et al. (1964

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“…The fact that polycythaemia and anaemia can be clinically demonstrated in renal disorders strongly supports the evidence for a renal formation of erythropoietin (1,17). In the vast majority of cases of nephrogenic polycythaemia the renal disease was found to be carcinoma (7,15).…”

Section: Ib Christiansen Kaj Kjerulf and Helce Worningmentioning

confidence: 62%