Incidence of SARS-CoV-2 infection in hospital workers before and after vaccination programme in East Java, Indonesia – a retrospective cohort study

Soegiarto, Gatot; Purnomosari, Dewajani; Wulandari, Laksmi; Mahdi, Bagus Aulia; Fahmita, Karin Dhia; Hadmoko, Satrio Tri; Gautama, Hendra Ikhwan; Prasetyo, Muhammad Edwin; Prasetyaningtyas, Dewi; Negoro, Pujo Prawiro; Arafah, Nur; Prakoeswa, Cita Rosita Sigit; Endaryanto, Anang; Suprabawati, Desak Gede Agung; Tinduh, Damayanti; Rachmad, Eka Basuki; Triyono, Erwin Astha; Wahyuhadi, Joni; Keswardiono, Catur Budi; Wardani, Feby Elyana; Mayorita, Fitriyah; Kristiani, Nunuk; Baskoro, Ari; Fetarayani, Deasy; Nurani, Wita Kartika; Oceandy, Delvac

doi:10.1016/j.lansea.2022.100130

Cited by 11 publications

(13 citation statements)

References 39 publications

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“… Targeted Testing: The Indonesian government has implemented targeted testing strategies to identify and test individuals who meet specific criteria. This includes individuals with symptoms consistent with COVID-19, close contacts of confirmed cases, healthcare workers, and high-risk populations, such as elderly individuals and those with underlying health conditions [ 48 , 49 ]. Targeted testing helps prioritize limited resources and focus efforts on populations at higher risk of infection.…”

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

“…It is pertinent to note that the mortality rate among healthcare workers is fivefold higher than that of the general population [ 65 ]. In the hopes to alleviate this, the government prioritized health care workers and support staff to be the first to be vaccinated as the vaccines initially entered the Indonesian market [ 48 , 60 ]. A study has presented precise insights into the incidence, hospitalization rates, and characteristics of COVID-19 cases among healthcare workers in East Java, Indonesia, comparing the periods before and after vaccination [ 48 ].…”

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

“…In the hopes to alleviate this, the government prioritized health care workers and support staff to be the first to be vaccinated as the vaccines initially entered the Indonesian market [ 48 , 60 ]. A study has presented precise insights into the incidence, hospitalization rates, and characteristics of COVID-19 cases among healthcare workers in East Java, Indonesia, comparing the periods before and after vaccination [ 48 ]. Despite the high vaccination coverage, the study was able to demonstrate that the risk of contracting COVID-19 remains elevated among healthcare workers in two major hospitals in East Java.…”

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

“…However, by the end of May 2021, the infection rate experienced a stark escalation, synchronizing with the rise of the Delta variant of the SARS-CoV-2 virus [ 66 ]. It is quite plausible that the safeguarding efficacy of the inactivated viral vaccine was significantly compromised against the Delta variant, as evidenced by the notable decline in vaccine effectiveness, plummeting from 73.3% to 17.6% upon the Delta variant's dominance in the province [ 48 ]. This observation aligns with earlier findings indicating the diminished vaccine effectiveness against the emerging Delta variant [ 67 , 68 ].…”

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

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From Archipelago to Pandemic Battleground: Unveiling Indonesia’s COVID-19 Crisis

Harapan,

Theodora

et al. 2023

J Epidemiol Glob Health

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The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to countries worldwide, including Indonesia. With its unique archipelagic geography consisting of more than 17,000 thousand islands, Indonesia faces unique complexities in managing the spread of the virus. Based on existing literature, this review article elaborates on key issues that have shaped Indonesia’s COVID-19 response. The article begins by examining the early stages of the COVID-19 pandemic in Indonesia, along with the implementation of various preventive measures and the impact of the virus on public health. This article examines how Indonesia’s socio-economic factors have generally influenced its healthcare system and further delves into the COVID-19 response strategies implemented by the Indonesian government and public health authorities as well as overall crisis preparedness. It discusses the actions taken to control the spread of the virus, including testing strategies and vaccination efforts. The difficulties encountered in implementing these measures are presented. In conclusion, this review article provides a comprehensive understanding of the COVID-19 crisis in Indonesia, covering facts on multiple dimensions ranging from the timeline of the pandemic to vaccination efforts, epidemiology, socio-economic implications, testing strategies, mobility patterns, public holidays, the impact of working from home, and the utilization of complementary and alternative medicine in addition to the standard of care for COVID-19. The insights gained from this article can complement future strategies for pandemic management and response in Indonesia and other countries facing similar challenges.

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Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

Section: Background and Key Issues Of The Covid-19 Pandemic In Indonesiamentioning

confidence: 99%

See 2 more Smart Citations

From Archipelago to Pandemic Battleground: Unveiling Indonesia’s COVID-19 Crisis

Harapan,

Theodora

et al. 2023

J Epidemiol Glob Health

View full text Add to dashboard Cite

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“…Indonesia was among the ten countries with the highest cumulative deaths, with 160,847 deaths reported ( World Health Organization, 2023 ). As an effort to mitigate the pandemic, the Indonesian authority kickstarted the national vaccination program on January 13, 2021 ( Soegiarto et al, 2023 ). Before that, the seroprevalence of SARS-CoV-2 infection was reported at around 11.4% in East Java ( Megasari et al, 2021 ), and the WHO reported 818,386 cumulative COVID-19 cases or 299.2 cases/100,000 population, with 23,947 cumulative deaths or 8.8 deaths/100,000 population in Indonesia ( World Health Organization, 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Cytokine profiles of mild-to-moderate SARS-CoV-2 infected and recovered pre-vaccinated individuals residing in Indonesia

Megasari,

Khairunisa,

Arizandy

et al. 2024

PeerJ

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Background Accumulating evidence suggests the involvement of cytokine-mediated inflammation, in clinical severity and death related to SARS-CoV-2 infection, especially among pre-vaccinated individuals. An increased risk of death was also described among SARS-CoV-2 recovered individuals, which might be correlated with prolonged inflammatory responses. Despite being among the countries with the highest cumulative deaths due to COVID-19, evidence regarding cytokine profiles among SARS-CoV-2 infected and recovered pre-vaccinated individuals in Indonesia is scarce. Thus, this study aimed to describe the cytokines profiles of pre-vaccinated individuals residing in Indonesia, with mild-to-moderate SARS-CoV-2 infection and those who recovered. Methods Sixty-one sera from 24 hospitalized patients with mild-to-moderate SARS-CoV-2 infection, 24 individuals recovered from asymptomatic-to-moderate SARS-CoV-2 infection, and 13 healthy controls unexposed to SARS-CoV-2 were used in this study. Quantification of serum cytokine levels, including IL-6, IL-8, IP-10, TNF-α, CCL-2, CCL-3, CCL-4, and CXCL-13, was performed using a Luminex multi-analyte-profiling (xMAP)-based assay. Results The levels of IL-8 along with CCL-2 and CCL-4, were significantly higher (p ≤ 0.01) in hospitalized patients with mild-to-moderate SARS-CoV-2 infection and recovered individuals compared to healthy controls. However, no significant difference was observed in these cytokine levels between infected and recovered individuals. On the other hand, there were no significant differences in several other cytokine levels, including IL-6, IL-10, TNF-α, CCL-3, and CXCL-13, among all groups. Conclusion IL-8, CCL-2, and CCL-4 were significantly elevated in pre-vaccinated Indonesian individuals with mild-to-moderate SARS-CoV-2 infection and those who recovered. The cytokine profiles described in this study might indicate inflammatory responses not only among SARS-CoV-2 infected, but also recovered individuals.

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The incidence of Coronavirus disease 2019 (COVID-19) among vaccinated healthcare workers (HCWs): evidence for protection from hospitalisation from an Indonesian cohort

Kozlakidis¹

2023

The Lancet Regional Health - Southeast Asia

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Incidence of SARS-CoV-2 infection in hospital workers before and after vaccination programme in East Java, Indonesia – a retrospective cohort study

Cited by 11 publications

References 39 publications

From Archipelago to Pandemic Battleground: Unveiling Indonesia’s COVID-19 Crisis

From Archipelago to Pandemic Battleground: Unveiling Indonesia’s COVID-19 Crisis

Cytokine profiles of mild-to-moderate SARS-CoV-2 infected and recovered pre-vaccinated individuals residing in Indonesia

The incidence of Coronavirus disease 2019 (COVID-19) among vaccinated healthcare workers (HCWs): evidence for protection from hospitalisation from an Indonesian cohort

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